Is adherence therapy an effective adjunct treatment for patients with schizophrenia spectrum disorders?: A systematic review and meta-analysis

Richard Gray; Daniel Bressington; Ada Ivanecka; Sheila Hardy; Martin Jones; Michael Schulz; Suparpit von Bormann; Jacquie White; Kathryn Hoehn Anderson; Wai Tong Chien

doi:10.1186/s12888-016-0801-1

Is adherence therapy an effective adjunct treatment for patients with schizophrenia spectrum disorders? A systematic review and meta-analysis

Richard Gray, Daniel Bressington, Ada Ivanecka, Sheila Hardy, Martin Jones, Michael Schulz, Suparpit von Bormann, Jacquie White, Kathryn Hoehn Anderson, Wai Tong Chien

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Abstract

Background: Poor adherence to medication in schizophrenia spectrum disorders leads to inadequate symptom control. Adherence therapy (AT) is an intervention that seeks to reduce patients' psychiatric symptoms by enhancing treatment adherence. We aimed to systematically review the trial evidence of the effectiveness of AT on improving clinical outcomes in these patients.

Method: Systematic review and meta-analysis of published RCTs. We included studies testing AT as an adjunct intervention against treatment as usual or a comparator intervention in the general adult psychiatric population. The primary outcome of interest was improvement in psychiatric symptoms.

Results: We included six studies testing AT in schizophrenia spectrum disorders published since 2006. A meta-analysis showed AT significantly reduced psychiatric symptoms compared to usual treatment over a follow-up period of less than 1 year. We found no significant effects of AT on patients' adherence and adherence attitudes.

Conclusions: AT is an effective adjunctive treatment for people with schizophrenia spectrum disorders.

Original language	English
Article number	90
Pages (from-to)	1-12
Number of pages	13
Journal	BMC Psychiatry
Volume	16
Issue number	1
DOIs	https://doi.org/10.1186/s12888-016-0801-1
Publication status	Published - 6 Apr 2016
Externally published	Yes

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10.1186/s12888-016-0801-1

41321340-oaFinal published version, 1.61 MBLicence: Other

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title = "Is adherence therapy an effective adjunct treatment for patients with schizophrenia spectrum disorders?: A systematic review and meta-analysis",

abstract = "Background: Poor adherence to medication in schizophrenia spectrum disorders leads to inadequate symptom control. Adherence therapy (AT) is an intervention that seeks to reduce patients' psychiatric symptoms by enhancing treatment adherence. We aimed to systematically review the trial evidence of the effectiveness of AT on improving clinical outcomes in these patients. Method: Systematic review and meta-analysis of published RCTs. We included studies testing AT as an adjunct intervention against treatment as usual or a comparator intervention in the general adult psychiatric population. The primary outcome of interest was improvement in psychiatric symptoms. Results: We included six studies testing AT in schizophrenia spectrum disorders published since 2006. A meta-analysis showed AT significantly reduced psychiatric symptoms compared to usual treatment over a follow-up period of less than 1 year. We found no significant effects of AT on patients' adherence and adherence attitudes. Conclusions: AT is an effective adjunctive treatment for people with schizophrenia spectrum disorders.",

keywords = "Adherence, Adherence therapy, Compliance, Meta-analysis, Schizophrenia, Schizophrenia-spectrum disorders, Systematic review",

author = "Richard Gray and Daniel Bressington and Ada Ivanecka and Sheila Hardy and Martin Jones and Michael Schulz and {von Bormann}, Suparpit and Jacquie White and Anderson, {Kathryn Hoehn} and Chien, {Wai Tong}",

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doi = "10.1186/s12888-016-0801-1",

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T1 - Is adherence therapy an effective adjunct treatment for patients with schizophrenia spectrum disorders?

T2 - A systematic review and meta-analysis

AU - Gray, Richard

AU - Bressington, Daniel

AU - Ivanecka, Ada

AU - Hardy, Sheila

AU - Jones, Martin

AU - Schulz, Michael

AU - von Bormann, Suparpit

AU - White, Jacquie

AU - Anderson, Kathryn Hoehn

AU - Chien, Wai Tong

PY - 2016/4/6

Y1 - 2016/4/6

N2 - Background: Poor adherence to medication in schizophrenia spectrum disorders leads to inadequate symptom control. Adherence therapy (AT) is an intervention that seeks to reduce patients' psychiatric symptoms by enhancing treatment adherence. We aimed to systematically review the trial evidence of the effectiveness of AT on improving clinical outcomes in these patients. Method: Systematic review and meta-analysis of published RCTs. We included studies testing AT as an adjunct intervention against treatment as usual or a comparator intervention in the general adult psychiatric population. The primary outcome of interest was improvement in psychiatric symptoms. Results: We included six studies testing AT in schizophrenia spectrum disorders published since 2006. A meta-analysis showed AT significantly reduced psychiatric symptoms compared to usual treatment over a follow-up period of less than 1 year. We found no significant effects of AT on patients' adherence and adherence attitudes. Conclusions: AT is an effective adjunctive treatment for people with schizophrenia spectrum disorders.

AB - Background: Poor adherence to medication in schizophrenia spectrum disorders leads to inadequate symptom control. Adherence therapy (AT) is an intervention that seeks to reduce patients' psychiatric symptoms by enhancing treatment adherence. We aimed to systematically review the trial evidence of the effectiveness of AT on improving clinical outcomes in these patients. Method: Systematic review and meta-analysis of published RCTs. We included studies testing AT as an adjunct intervention against treatment as usual or a comparator intervention in the general adult psychiatric population. The primary outcome of interest was improvement in psychiatric symptoms. Results: We included six studies testing AT in schizophrenia spectrum disorders published since 2006. A meta-analysis showed AT significantly reduced psychiatric symptoms compared to usual treatment over a follow-up period of less than 1 year. We found no significant effects of AT on patients' adherence and adherence attitudes. Conclusions: AT is an effective adjunctive treatment for people with schizophrenia spectrum disorders.

KW - Adherence

KW - Adherence therapy

KW - Compliance

KW - Meta-analysis

KW - Schizophrenia

KW - Schizophrenia-spectrum disorders

KW - Systematic review

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U2 - 10.1186/s12888-016-0801-1

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M3 - Review article

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JO - BMC Psychiatry

JF - BMC Psychiatry

SN - 1471-244X

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M1 - 90

ER -

Is adherence therapy an effective adjunct treatment for patients with schizophrenia spectrum disorders? A systematic review and meta-analysis

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