Is NXY-059 an advancement in the treatment of acute ischaemic stroke?

Sheila A. Doggrel

    Research output: Contribution to journalComment/debate

    Abstract

    The only pharmacological treatment for acute ischaemic stroke used at present is tissue plasminogen activator. The nitrone NXY-049 has been shown to be neuroprotective in a variety of animal models. The SAINT (Stoke Acute Ischemic NXY-059 Treatment) 1 trial has shown that, on the modified Rankin scale at 90 days, there were slightly more patients with no symptoms in the NXY-059 group than the placebo group. Conversely, there were slightly fewer patients with a score of 4 (moderately-severe disability) in the NXY-059 group than placebo group. NXY-059 was well tolerated. These data suggest that NXY-059 may be a modest advancement for the treatment of acute ischaemic stroke.
    Original languageEnglish
    Pages (from-to)965-968
    Number of pages4
    JournalExpert Opinion on Pharmacotherapy
    Volume7
    Issue number7
    DOIs
    Publication statusPublished - 2006

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