Left Ventricular Non-compaction in Holt-Oram Syndrome

Renuka Kapadia, Preeti Choudhary, Nicholas Collins, David Celermajer, Rajesh Puranik

Research output: Contribution to journalArticlepeer-review


Holt-Oram Syndrome is an autosomal dominant condition with complete penetrance and which involves upper limb skeletal and cardiac abnormalities. The latter can be structural defects or involve the conduction system. This report details the occurrence of left ventricular non-compaction in multiple family members with Holt-Oram Syndrome. It is recommended that patients with the Holt-Oram Syndrome be considered for comprehensive cardiac evaluation to exclude non-compaction cardiomyopathy as this may have significant prognostic implications.

Original languageEnglish
Pages (from-to)626-630
Number of pages5
JournalHeart Lung and Circulation
Issue number6
Publication statusPublished - Jun 2016
Externally publishedYes


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