TY - JOUR
T1 - Letter to the editor
T2 - Is HIF-1α a viable prognostic indicator in OSCC? A critical review of a meta-analysis study
AU - Jayaraj, Rama
AU - Kumarasamy, Chellan
AU - Madurantakam Royam, Madhav
AU - Devi, Arikketh
AU - Baxi, Siddharta
PY - 2018/6/18
Y1 - 2018/6/18
N2 - The study performed by Zhou et al. (World J Surg Oncol 15:104, 2017) titled "Clinical and prognostic significance of HIF-1α overexpression in oral squamous cell carcinoma: a meta-analysis" attempts to highlight hypoxia-inducible factor-1 alpha as a possible prognostic marker in oral squamous cell carcinoma (OSCC). We would like to underline a few points which may affect such a conclusion. The correlations between HIF-1α expression and tumour size as well as tumour stage are debatable. Further, the subgroup analysis incorporating Australia and Europe into a single subgroup limits the viability of the prognostic analysis of HIF-1α. We also suggest future studies in the same research area to analyse head and neck squamous cell carcinoma instead of OSCC, to ameliorate the limitations encountered by Zhou et al., due to the scarcity of relevant clinical data and a low number of studies about OSCC.
AB - The study performed by Zhou et al. (World J Surg Oncol 15:104, 2017) titled "Clinical and prognostic significance of HIF-1α overexpression in oral squamous cell carcinoma: a meta-analysis" attempts to highlight hypoxia-inducible factor-1 alpha as a possible prognostic marker in oral squamous cell carcinoma (OSCC). We would like to underline a few points which may affect such a conclusion. The correlations between HIF-1α expression and tumour size as well as tumour stage are debatable. Further, the subgroup analysis incorporating Australia and Europe into a single subgroup limits the viability of the prognostic analysis of HIF-1α. We also suggest future studies in the same research area to analyse head and neck squamous cell carcinoma instead of OSCC, to ameliorate the limitations encountered by Zhou et al., due to the scarcity of relevant clinical data and a low number of studies about OSCC.
KW - HIF-1α
KW - Letter to the editor
KW - Oral squamous cell carcinoma
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=85048732906&partnerID=8YFLogxK
U2 - 10.1186/s12957-018-1408-4
DO - 10.1186/s12957-018-1408-4
M3 - Letter
C2 - 29914529
AN - SCOPUS:85048732906
SN - 1477-7819
VL - 16
SP - 1
EP - 2
JO - World Journal of Surgical Oncology
JF - World Journal of Surgical Oncology
M1 - 111
ER -
