Ligand-Free RuCl3-Catalyzed Alkylation of Methylazaarenes with Alcohols

Tong Yu Feng, Hong Xi Li, David James Young, Jian Ping Lang

Research output: Contribution to journalArticlepeer-review


RuCl3 efficiently catalyzes the alkylation of methylquinolines, methylpyridines, 2-methyl-benzooxazoles, and 2-methyl-quinoxalines with alkyl- or aryl-alcohols as alkylating agents. This synthetically useful and atom economical transformation does not require additional ligands. The mechanistic study indicated the alkylation reaction underwent a stepwise transfer hydrogenation, aldol condensation, and hydrogenation reaction pathway.

Original languageEnglish
Pages (from-to)4113-4120
Number of pages8
JournalJournal of Organic Chemistry
Issue number8
Publication statusPublished - 21 Apr 2017
Externally publishedYes


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