Links2HealthierBubs' cohort study

Protocol for a record linkage study on the safety, uptake and effectiveness of influenza and pertussis vaccines among pregnant Australian women

Mohinder Sarna, Ross Andrews, Hannah Moore, Michael J. Binks, Lisa Mchugh, Gavin F. Pereira, Christopher C. Blyth, Paul Van Buynder, Karin Lust, Paul Effler, Stephen B. Lambert, Saad B. Omer, Donna B. Mak, Thomas Snelling, Heather A. D'antoine, Peter Mcintyre, Nicholas De Klerk, Damien Foo, Annette K. Regan

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    Abstract

    Introduction: Pregnant women and infants are at risk of severe influenza and pertussis infection. Inactivated influenza vaccine (IIV) and diphtheria-tetanus-acellular pertussis vaccine (dTpa) are recommended during pregnancy to protect both mothers and infants. In Australia, uptake is not routinely monitored but coverage appears sub-optimal. Evidence on the safety of combined antenatal IIV and dTpa is fragmented or deficient, and there remain knowledge gaps of population-level vaccine effectiveness. We aim to establish a large, population-based, multi-jurisdictional cohort of mother-infant pairs to measure the uptake, safety and effectiveness of antenatal IIV and dTpa vaccines in three Australian jurisdictions. This is a first step toward assessing the impact of antenatal vaccination programmes in Australia, which can then inform government policy with respect to future strategies in national vaccination programmes.

    Methods and analysis: ' Links2HealthierBubs' is an observational, population-based, retrospective cohort study established through probabilistic record linkage of administrative health data. The cohort includes births between 2012 and 2017 (∼607 605 mother-infant pairs) in jurisdictions with population-level antenatal vaccination and health outcome data (Western Australia, Queensland and the Northern Territory). Perinatal data will be the reference frame to identify the cohort. Jurisdictional vaccination registers will identify antenatal vaccination status and the gestational timing of vaccination. Information on maternal, fetal and child health outcomes will be obtained from hospitalisation and emergency department records, notifiable diseases databases, developmental anomalies databases, birth and mortality registers.

    Ethics and dissemination: Ethical approval was obtained from the Western Australian Department of Health, Curtin University, the Menzies School of Health Research, the Royal Brisbane and Women's Hospital, and the West Australian Aboriginal Health Ethics Committees. Research findings will be disseminated in peer-reviewed journals, at scientific meetings, and may be incorporated into communication materials for public health agencies and the public.

    Original languageEnglish
    Article numbere030277
    Pages (from-to)1-9
    Number of pages9
    JournalBMJ Open
    Volume9
    Issue number6
    DOIs
    Publication statusPublished - 1 May 2019

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    Pertussis Vaccine
    Influenza Vaccines
    Pregnant Women
    Vaccination
    Cohort Studies
    Diphtheria-Tetanus-acellular Pertussis Vaccines
    Safety
    Inactivated Vaccines
    Mothers
    Health
    Population
    Vaccines
    Parturition
    Northern Territory
    Databases
    Ethics Committees
    Western Australia
    Queensland
    School Health Services
    Whooping Cough

    Cite this

    Sarna, Mohinder ; Andrews, Ross ; Moore, Hannah ; Binks, Michael J. ; Mchugh, Lisa ; Pereira, Gavin F. ; Blyth, Christopher C. ; Van Buynder, Paul ; Lust, Karin ; Effler, Paul ; Lambert, Stephen B. ; Omer, Saad B. ; Mak, Donna B. ; Snelling, Thomas ; D'antoine, Heather A. ; Mcintyre, Peter ; De Klerk, Nicholas ; Foo, Damien ; Regan, Annette K. / Links2HealthierBubs' cohort study : Protocol for a record linkage study on the safety, uptake and effectiveness of influenza and pertussis vaccines among pregnant Australian women. In: BMJ Open. 2019 ; Vol. 9, No. 6. pp. 1-9.
    @article{bc51423bc43e40f2822a85881b2e2b46,
    title = "Links2HealthierBubs' cohort study: Protocol for a record linkage study on the safety, uptake and effectiveness of influenza and pertussis vaccines among pregnant Australian women",
    abstract = "Introduction: Pregnant women and infants are at risk of severe influenza and pertussis infection. Inactivated influenza vaccine (IIV) and diphtheria-tetanus-acellular pertussis vaccine (dTpa) are recommended during pregnancy to protect both mothers and infants. In Australia, uptake is not routinely monitored but coverage appears sub-optimal. Evidence on the safety of combined antenatal IIV and dTpa is fragmented or deficient, and there remain knowledge gaps of population-level vaccine effectiveness. We aim to establish a large, population-based, multi-jurisdictional cohort of mother-infant pairs to measure the uptake, safety and effectiveness of antenatal IIV and dTpa vaccines in three Australian jurisdictions. This is a first step toward assessing the impact of antenatal vaccination programmes in Australia, which can then inform government policy with respect to future strategies in national vaccination programmes. Methods and analysis: ' Links2HealthierBubs' is an observational, population-based, retrospective cohort study established through probabilistic record linkage of administrative health data. The cohort includes births between 2012 and 2017 (∼607 605 mother-infant pairs) in jurisdictions with population-level antenatal vaccination and health outcome data (Western Australia, Queensland and the Northern Territory). Perinatal data will be the reference frame to identify the cohort. Jurisdictional vaccination registers will identify antenatal vaccination status and the gestational timing of vaccination. Information on maternal, fetal and child health outcomes will be obtained from hospitalisation and emergency department records, notifiable diseases databases, developmental anomalies databases, birth and mortality registers. Ethics and dissemination: Ethical approval was obtained from the Western Australian Department of Health, Curtin University, the Menzies School of Health Research, the Royal Brisbane and Women's Hospital, and the West Australian Aboriginal Health Ethics Committees. Research findings will be disseminated in peer-reviewed journals, at scientific meetings, and may be incorporated into communication materials for public health agencies and the public.",
    keywords = "antenatal, immunisation, vaccine",
    author = "Mohinder Sarna and Ross Andrews and Hannah Moore and Binks, {Michael J.} and Lisa Mchugh and Pereira, {Gavin F.} and Blyth, {Christopher C.} and {Van Buynder}, Paul and Karin Lust and Paul Effler and Lambert, {Stephen B.} and Omer, {Saad B.} and Mak, {Donna B.} and Thomas Snelling and D'antoine, {Heather A.} and Peter Mcintyre and {De Klerk}, Nicholas and Damien Foo and Regan, {Annette K.}",
    year = "2019",
    month = "5",
    day = "1",
    doi = "10.1136/bmjopen-2019-030277",
    language = "English",
    volume = "9",
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    journal = "BMJ Open",
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    Sarna, M, Andrews, R, Moore, H, Binks, MJ, Mchugh, L, Pereira, GF, Blyth, CC, Van Buynder, P, Lust, K, Effler, P, Lambert, SB, Omer, SB, Mak, DB, Snelling, T, D'antoine, HA, Mcintyre, P, De Klerk, N, Foo, D & Regan, AK 2019, 'Links2HealthierBubs' cohort study: Protocol for a record linkage study on the safety, uptake and effectiveness of influenza and pertussis vaccines among pregnant Australian women', BMJ Open, vol. 9, no. 6, e030277, pp. 1-9. https://doi.org/10.1136/bmjopen-2019-030277

    Links2HealthierBubs' cohort study : Protocol for a record linkage study on the safety, uptake and effectiveness of influenza and pertussis vaccines among pregnant Australian women. / Sarna, Mohinder; Andrews, Ross; Moore, Hannah; Binks, Michael J.; Mchugh, Lisa; Pereira, Gavin F.; Blyth, Christopher C.; Van Buynder, Paul; Lust, Karin; Effler, Paul; Lambert, Stephen B.; Omer, Saad B.; Mak, Donna B.; Snelling, Thomas; D'antoine, Heather A.; Mcintyre, Peter; De Klerk, Nicholas; Foo, Damien; Regan, Annette K.

    In: BMJ Open, Vol. 9, No. 6, e030277, 01.05.2019, p. 1-9.

    Research output: Contribution to journalArticleResearchpeer-review

    TY - JOUR

    T1 - Links2HealthierBubs' cohort study

    T2 - Protocol for a record linkage study on the safety, uptake and effectiveness of influenza and pertussis vaccines among pregnant Australian women

    AU - Sarna, Mohinder

    AU - Andrews, Ross

    AU - Moore, Hannah

    AU - Binks, Michael J.

    AU - Mchugh, Lisa

    AU - Pereira, Gavin F.

    AU - Blyth, Christopher C.

    AU - Van Buynder, Paul

    AU - Lust, Karin

    AU - Effler, Paul

    AU - Lambert, Stephen B.

    AU - Omer, Saad B.

    AU - Mak, Donna B.

    AU - Snelling, Thomas

    AU - D'antoine, Heather A.

    AU - Mcintyre, Peter

    AU - De Klerk, Nicholas

    AU - Foo, Damien

    AU - Regan, Annette K.

    PY - 2019/5/1

    Y1 - 2019/5/1

    N2 - Introduction: Pregnant women and infants are at risk of severe influenza and pertussis infection. Inactivated influenza vaccine (IIV) and diphtheria-tetanus-acellular pertussis vaccine (dTpa) are recommended during pregnancy to protect both mothers and infants. In Australia, uptake is not routinely monitored but coverage appears sub-optimal. Evidence on the safety of combined antenatal IIV and dTpa is fragmented or deficient, and there remain knowledge gaps of population-level vaccine effectiveness. We aim to establish a large, population-based, multi-jurisdictional cohort of mother-infant pairs to measure the uptake, safety and effectiveness of antenatal IIV and dTpa vaccines in three Australian jurisdictions. This is a first step toward assessing the impact of antenatal vaccination programmes in Australia, which can then inform government policy with respect to future strategies in national vaccination programmes. Methods and analysis: ' Links2HealthierBubs' is an observational, population-based, retrospective cohort study established through probabilistic record linkage of administrative health data. The cohort includes births between 2012 and 2017 (∼607 605 mother-infant pairs) in jurisdictions with population-level antenatal vaccination and health outcome data (Western Australia, Queensland and the Northern Territory). Perinatal data will be the reference frame to identify the cohort. Jurisdictional vaccination registers will identify antenatal vaccination status and the gestational timing of vaccination. Information on maternal, fetal and child health outcomes will be obtained from hospitalisation and emergency department records, notifiable diseases databases, developmental anomalies databases, birth and mortality registers. Ethics and dissemination: Ethical approval was obtained from the Western Australian Department of Health, Curtin University, the Menzies School of Health Research, the Royal Brisbane and Women's Hospital, and the West Australian Aboriginal Health Ethics Committees. Research findings will be disseminated in peer-reviewed journals, at scientific meetings, and may be incorporated into communication materials for public health agencies and the public.

    AB - Introduction: Pregnant women and infants are at risk of severe influenza and pertussis infection. Inactivated influenza vaccine (IIV) and diphtheria-tetanus-acellular pertussis vaccine (dTpa) are recommended during pregnancy to protect both mothers and infants. In Australia, uptake is not routinely monitored but coverage appears sub-optimal. Evidence on the safety of combined antenatal IIV and dTpa is fragmented or deficient, and there remain knowledge gaps of population-level vaccine effectiveness. We aim to establish a large, population-based, multi-jurisdictional cohort of mother-infant pairs to measure the uptake, safety and effectiveness of antenatal IIV and dTpa vaccines in three Australian jurisdictions. This is a first step toward assessing the impact of antenatal vaccination programmes in Australia, which can then inform government policy with respect to future strategies in national vaccination programmes. Methods and analysis: ' Links2HealthierBubs' is an observational, population-based, retrospective cohort study established through probabilistic record linkage of administrative health data. The cohort includes births between 2012 and 2017 (∼607 605 mother-infant pairs) in jurisdictions with population-level antenatal vaccination and health outcome data (Western Australia, Queensland and the Northern Territory). Perinatal data will be the reference frame to identify the cohort. Jurisdictional vaccination registers will identify antenatal vaccination status and the gestational timing of vaccination. Information on maternal, fetal and child health outcomes will be obtained from hospitalisation and emergency department records, notifiable diseases databases, developmental anomalies databases, birth and mortality registers. Ethics and dissemination: Ethical approval was obtained from the Western Australian Department of Health, Curtin University, the Menzies School of Health Research, the Royal Brisbane and Women's Hospital, and the West Australian Aboriginal Health Ethics Committees. Research findings will be disseminated in peer-reviewed journals, at scientific meetings, and may be incorporated into communication materials for public health agencies and the public.

    KW - antenatal

    KW - immunisation

    KW - vaccine

    UR - http://www.scopus.com/inward/record.url?scp=85067844919&partnerID=8YFLogxK

    U2 - 10.1136/bmjopen-2019-030277

    DO - 10.1136/bmjopen-2019-030277

    M3 - Article

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    EP - 9

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    SN - 2044-6055

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    ER -