Lipoprotein(a) identifies cardiovascular risk in childhood

the Australian Aboriginal Birth Cohort Study

Teresa Cunningham, Susan Sayers, Gurmeet Singh

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Aim: To describe the lipoprotein(a) (Lp(a) )profile and its relationship to cardiovascular risk factors in Australian Aboriginal children.

     

    Methods: A cross-sectional study within a longitudinal birth cohort study in the Darwin Health Region (Northern Territory, Australia). Subjects were Aboriginal children born between 1987 and 1990 who were re-examined between 1998 and 2001. Outcome measures were cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apoB, apoA1, apoA1/B ratio, anthropometric measures, cardiovascular disease (CVD) risk factors, maternal smoking and nutrition.

     

    Results: At a mean age of 11.4 years, results showed that high concentrations of Lp(a) were significantly related to well-known lipid-based CVD risk factors for both boys and girls, and that only one anthropometric factor, height, was significant for girls. Non-genetic factors and maternal smoking were not found to be significant contributors to Lp(a) concentrations.

     

    Conclusions: Lp(a) should be considered as a more effective marker of CVD than anthropometric measures, and children from families with a history of premature CVD should be regularly screened for this factor.

    Original languageEnglish
    Pages (from-to)257-261
    Number of pages5
    JournalJournal of Paediatrics and Child Health
    Volume47
    Issue number5
    DOIs
    Publication statusPublished - May 2011

    Fingerprint

    Lipoprotein(a)
    Cohort Studies
    Cardiovascular Diseases
    Parturition
    Smoking
    Mothers
    Apolipoproteins B
    HDL Cholesterol
    Triglycerides
    Cholesterol
    Outcome Assessment (Health Care)
    Lipids
    Health

    Cite this

    @article{3b6492eb4618430db0791bfcba8c6502,
    title = "Lipoprotein(a) identifies cardiovascular risk in childhood: the Australian Aboriginal Birth Cohort Study",
    abstract = "Aim: To describe the lipoprotein(a) (Lp(a) )profile and its relationship to cardiovascular risk factors in Australian Aboriginal children.   Methods: A cross-sectional study within a longitudinal birth cohort study in the Darwin Health Region (Northern Territory, Australia). Subjects were Aboriginal children born between 1987 and 1990 who were re-examined between 1998 and 2001. Outcome measures were cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apoB, apoA1, apoA1/B ratio, anthropometric measures, cardiovascular disease (CVD) risk factors, maternal smoking and nutrition.   Results: At a mean age of 11.4 years, results showed that high concentrations of Lp(a) were significantly related to well-known lipid-based CVD risk factors for both boys and girls, and that only one anthropometric factor, height, was significant for girls. Non-genetic factors and maternal smoking were not found to be significant contributors to Lp(a) concentrations.   Conclusions: Lp(a) should be considered as a more effective marker of CVD than anthropometric measures, and children from families with a history of premature CVD should be regularly screened for this factor.",
    keywords = "apolipoprotein A1, apolipoprotein B, cholesterol, folic acid, hemoglobin, high density lipoprotein cholesterol, insulin, lipoprotein A, low density lipoprotein cholesterol, triacylglycerol, Aborigine, article, Australia, birth weight, body fat, body height, body mass, body weight, cardiovascular risk, child, cohort analysis, controlled study, cross-sectional study, diastolic blood pressure, erythrocyte sedimentation rate, female, heredity, human, leukocyte count, lipoprotein blood level, longitudinal study, major clinical study, male, maternal smoking, nutrition, outcome assessment, priority journal, risk assessment, school child, sex difference, skinfold, systolic blood pressure, waist circumference, Anthropometry, Biological Markers, Cardiovascular Diseases, Child, Cohort Studies, Cross-Sectional Studies, Female, Humans, Lipoprotein(a), Male, Oceanic Ancestry Group, Risk Factors",
    author = "Teresa Cunningham and Susan Sayers and Gurmeet Singh",
    year = "2011",
    month = "5",
    doi = "10.1111/j.1440-1754.2010.01955.x",
    language = "English",
    volume = "47",
    pages = "257--261",
    journal = "Journal of Paediatrics and Child Health",
    issn = "1034-4810",
    publisher = "Wiley-Blackwell",
    number = "5",

    }

    Lipoprotein(a) identifies cardiovascular risk in childhood : the Australian Aboriginal Birth Cohort Study. / Cunningham, Teresa; Sayers, Susan; Singh, Gurmeet.

    In: Journal of Paediatrics and Child Health, Vol. 47, No. 5, 05.2011, p. 257-261.

    Research output: Contribution to journalArticleResearchpeer-review

    TY - JOUR

    T1 - Lipoprotein(a) identifies cardiovascular risk in childhood

    T2 - the Australian Aboriginal Birth Cohort Study

    AU - Cunningham, Teresa

    AU - Sayers, Susan

    AU - Singh, Gurmeet

    PY - 2011/5

    Y1 - 2011/5

    N2 - Aim: To describe the lipoprotein(a) (Lp(a) )profile and its relationship to cardiovascular risk factors in Australian Aboriginal children.   Methods: A cross-sectional study within a longitudinal birth cohort study in the Darwin Health Region (Northern Territory, Australia). Subjects were Aboriginal children born between 1987 and 1990 who were re-examined between 1998 and 2001. Outcome measures were cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apoB, apoA1, apoA1/B ratio, anthropometric measures, cardiovascular disease (CVD) risk factors, maternal smoking and nutrition.   Results: At a mean age of 11.4 years, results showed that high concentrations of Lp(a) were significantly related to well-known lipid-based CVD risk factors for both boys and girls, and that only one anthropometric factor, height, was significant for girls. Non-genetic factors and maternal smoking were not found to be significant contributors to Lp(a) concentrations.   Conclusions: Lp(a) should be considered as a more effective marker of CVD than anthropometric measures, and children from families with a history of premature CVD should be regularly screened for this factor.

    AB - Aim: To describe the lipoprotein(a) (Lp(a) )profile and its relationship to cardiovascular risk factors in Australian Aboriginal children.   Methods: A cross-sectional study within a longitudinal birth cohort study in the Darwin Health Region (Northern Territory, Australia). Subjects were Aboriginal children born between 1987 and 1990 who were re-examined between 1998 and 2001. Outcome measures were cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apoB, apoA1, apoA1/B ratio, anthropometric measures, cardiovascular disease (CVD) risk factors, maternal smoking and nutrition.   Results: At a mean age of 11.4 years, results showed that high concentrations of Lp(a) were significantly related to well-known lipid-based CVD risk factors for both boys and girls, and that only one anthropometric factor, height, was significant for girls. Non-genetic factors and maternal smoking were not found to be significant contributors to Lp(a) concentrations.   Conclusions: Lp(a) should be considered as a more effective marker of CVD than anthropometric measures, and children from families with a history of premature CVD should be regularly screened for this factor.

    KW - apolipoprotein A1

    KW - apolipoprotein B

    KW - cholesterol

    KW - folic acid

    KW - hemoglobin

    KW - high density lipoprotein cholesterol

    KW - insulin

    KW - lipoprotein A

    KW - low density lipoprotein cholesterol

    KW - triacylglycerol

    KW - Aborigine

    KW - article

    KW - Australia

    KW - birth weight

    KW - body fat

    KW - body height

    KW - body mass

    KW - body weight

    KW - cardiovascular risk

    KW - child

    KW - cohort analysis

    KW - controlled study

    KW - cross-sectional study

    KW - diastolic blood pressure

    KW - erythrocyte sedimentation rate

    KW - female

    KW - heredity

    KW - human

    KW - leukocyte count

    KW - lipoprotein blood level

    KW - longitudinal study

    KW - major clinical study

    KW - male

    KW - maternal smoking

    KW - nutrition

    KW - outcome assessment

    KW - priority journal

    KW - risk assessment

    KW - school child

    KW - sex difference

    KW - skinfold

    KW - systolic blood pressure

    KW - waist circumference

    KW - Anthropometry

    KW - Biological Markers

    KW - Cardiovascular Diseases

    KW - Child

    KW - Cohort Studies

    KW - Cross-Sectional Studies

    KW - Female

    KW - Humans

    KW - Lipoprotein(a)

    KW - Male

    KW - Oceanic Ancestry Group

    KW - Risk Factors

    U2 - 10.1111/j.1440-1754.2010.01955.x

    DO - 10.1111/j.1440-1754.2010.01955.x

    M3 - Article

    VL - 47

    SP - 257

    EP - 261

    JO - Journal of Paediatrics and Child Health

    JF - Journal of Paediatrics and Child Health

    SN - 1034-4810

    IS - 5

    ER -