Abstract
Fasciola’s excretory-secretory material comprises chiefly cathepsin B and cathepsin L. These
cysteine proteases are proposed as major mediators of parasitism, and are considered targets for
vaccination. In order to assess the vaccine efficacy of these enzymes, single and multivalent
recombinant protein vaccinations of adult-stage F. hepatica cathepsin L5, metacercarial-stage F.
gigantica cathepsin L1g and juvenile-stage protective efficacy of anti-fluke vaccines was
evaluated in terms of parasitological parameters (recovered fluke burden, fluke body size and wet
weight) and pathological changes (liver damage score) in rats. The rats vaccinated with
recombinant proteins were shown to have significantly fewer and smaller flukes than the control
rats. A maximum protection of 83% was seen in the group vaccinated with a combination of
cathepsin B and cathepsin L5.
Original language | English |
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Publication status | Published - 2011 |
Event | Australian Society for Immunology International Conference - Adelaide Duration: 11 Dec 2011 → 15 Dec 2011 |
Conference
Conference | Australian Society for Immunology International Conference |
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Period | 11/12/11 → 15/12/11 |