TY - JOUR
T1 - Longitudinal study of quality of life among children with acute respiratory infection and cough
AU - Lovie-Toon, Yolanda G.
AU - Chang, Anne
AU - Newcombe, Peter A.
AU - Vagenas, Dimitrios
AU - Anderson-James, Sophie
AU - Drescher, Benjamin J
AU - E. Otim, Michael
AU - O’Grady, Kerry Ann F
PY - 2018/4
Y1 - 2018/4
N2 - Purpose: Acute respiratory infections (ARIs), and associated symptoms
such as cough, are frequently experienced among children and impose a burden on
families (e.g., use of medical resources and time off work/school). However,
there are little data on changes in, and predictors of, quality of life (QoL)
over the duration of an ARI with cough (ARIwC) episode. We therefore aimed to
determine cough-specific QoL and identify its influencing factors among
children with ARIwC, at the time of presentation to a pediatric emergency
department (ED), and over the following 4 weeks.
Methods: Data from 283 children aged < 15 years were included in
our analyses. We used the validated parent-proxy children’s acute
cough-specific QoL questionnaire (PAC-QoL) at each time-point. Linear
regression and mixed effect modeling were used to identify factors influencing
QoL at baseline and over the follow-up period.
Results: Median
PAC-QoL at baseline was 2.7 (IQR 2.1–3.6) and significantly improved by Day-7
(4.9, IQR 3.8–6.1) and Day-14 (6.59, IQR 5.1–7.0), both p < 0.001. The
improvements in median PAC-QoL between Days-14, -21, and -28 were not
significant. Regression modeling identified that day-cough severity,
night-cough severity, and financial concerns had the highest impact on both
baseline, and follow-up, PAC-QoL scores. There were five additional independent
significant factors at baseline and six at follow-up.
Conclusions: Quality of life is considerably impaired at
presentation to ED, but improves significantly by Days-7 and -14. As cough
severity and financial concerns had the highest impact on QoL, effectively
managing cough to reduce the clinical and financial burden on children and
families is important.
AB - Purpose: Acute respiratory infections (ARIs), and associated symptoms
such as cough, are frequently experienced among children and impose a burden on
families (e.g., use of medical resources and time off work/school). However,
there are little data on changes in, and predictors of, quality of life (QoL)
over the duration of an ARI with cough (ARIwC) episode. We therefore aimed to
determine cough-specific QoL and identify its influencing factors among
children with ARIwC, at the time of presentation to a pediatric emergency
department (ED), and over the following 4 weeks.
Methods: Data from 283 children aged < 15 years were included in
our analyses. We used the validated parent-proxy children’s acute
cough-specific QoL questionnaire (PAC-QoL) at each time-point. Linear
regression and mixed effect modeling were used to identify factors influencing
QoL at baseline and over the follow-up period.
Results: Median
PAC-QoL at baseline was 2.7 (IQR 2.1–3.6) and significantly improved by Day-7
(4.9, IQR 3.8–6.1) and Day-14 (6.59, IQR 5.1–7.0), both p < 0.001. The
improvements in median PAC-QoL between Days-14, -21, and -28 were not
significant. Regression modeling identified that day-cough severity,
night-cough severity, and financial concerns had the highest impact on both
baseline, and follow-up, PAC-QoL scores. There were five additional independent
significant factors at baseline and six at follow-up.
Conclusions: Quality of life is considerably impaired at
presentation to ED, but improves significantly by Days-7 and -14. As cough
severity and financial concerns had the highest impact on QoL, effectively
managing cough to reduce the clinical and financial burden on children and
families is important.
UR - http://www.scopus.com/inward/record.url?scp=85040768185&partnerID=8YFLogxK
U2 - 10.1007/s11136-017-1779-y
DO - 10.1007/s11136-017-1779-y
M3 - Article
C2 - 29357027
SN - 0962-9343
VL - 27
SP - 891
EP - 903
JO - Quality of Life Research
JF - Quality of Life Research
IS - 4
ER -