Malaria tolerance - for whom the cell tolls?

Research output: Contribution to journalArticlepeer-review


How is it that individuals exposed to intense malaria transmission can tolerate the presence of malaria parasites in their blood at levels that would produce fever in others? In light of evidence discounting a role for nitric oxide or antibodies to plasmodial glycosylphosphatidylinositols in maintaining this tolerant state, refractoriness to toxin-induced Toll-like receptor-mediated signalling has emerged as a likely explanation that links malarial and bacterial endotoxin tolerance. Understanding the mechanisms underlying tolerance and the potential for cross-tolerization has significant implications for understanding the potential for antitoxic vaccine strategies, as well as interactions between different malaria species and between malaria and other human parasites. � 2006 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)371-377
Number of pages7
JournalTrends in Parasitology
Issue number8
Publication statusPublished - 2006


Dive into the research topics of 'Malaria tolerance - for whom the cell tolls?'. Together they form a unique fingerprint.

Cite this