Malaria tolerance - for whom the cell tolls?

C BOUTLIS, Tsin Yeo, Nicholas Anstey

    Research output: Contribution to journalArticle

    Abstract

    How is it that individuals exposed to intense malaria transmission can tolerate the presence of malaria parasites in their blood at levels that would produce fever in others? In light of evidence discounting a role for nitric oxide or antibodies to plasmodial glycosylphosphatidylinositols in maintaining this tolerant state, refractoriness to toxin-induced Toll-like receptor-mediated signalling has emerged as a likely explanation that links malarial and bacterial endotoxin tolerance. Understanding the mechanisms underlying tolerance and the potential for cross-tolerization has significant implications for understanding the potential for antitoxic vaccine strategies, as well as interactions between different malaria species and between malaria and other human parasites. � 2006 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)371-377
    Number of pages7
    JournalTrends in Parasitology
    Volume22
    Issue number8
    Publication statusPublished - 2006

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