Maternal alcohol use and sudden infant death syndrome and infant mortality excluding SIDS

Colleen O'Leary, Peter Jacoby, Anne Bartu, Heather D'Antoine, C Bower

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Background: Improvements in the rate of infant mortality (death in first year of life) have not occurred in recent years. This study investigates the association between maternal alcohol-use disorder and sudden infant death syndrome (SIDS) and infant mortality not classified as SIDS using linked, population-based health and mortality data.

    Methods: Exposed mothers were identified through the presence of an International Classification of Diseases 9/10 alcohol diagnosis, a proxy for alcohol-use disorder, recorded on health, mental health, and/or drug and alcohol datasets (1983-2005). Comparison mothers without an alcohol diagnosis were frequency matched to exposed mothers on maternal age within maternal race and year of birth of their children. All offspring with their birth recorded on the Midwives Notification System compose the exposed (n = 21 841) and comparison (n= 56 054) cohorts. Cases of SIDS (n = 303) and infant mortality excluding SIDS(n = 598) were identified through linkage with the Western Australian Mortality Register. Analyses were conducted by using Cox regression and results presented as adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs).

    Results: The highest risk of SIDS occurred when a maternal alcohol diagnosis was recorded during pregnancy (aHR 6.92, 95% CI 4.02-11.90) or within 1 year postpregnancy (aHR 8.61, 95% CI 5.04-14.69). An alcohol diagnosis recorded during pregnancy more than doubled the risk of infant deaths (excluding SIDS) (aHR 2.35, 95% CI 1.45-3.83). Maternal alcohol-use disorder is attributable for at least 16.41% (95% CI 9.73%-23.69%) of SIDS and 3.40% (95% CI 2.28%-4.67%) of infant deaths not classified as SIDS.

    Conclusions: Maternal alcohol-use disorder is asignificant risk factor for SIDS and infant mortality excluding SIDS.

    Original languageEnglish
    Pages (from-to)e770-e778
    Number of pages9
    JournalPediatrics
    Volume131
    Issue number3
    DOIs
    Publication statusPublished - Mar 2013

    Fingerprint

    Sudden Infant Death
    Infant Mortality
    Alcohols
    Mothers
    Confidence Intervals
    Parturition
    Pregnancy
    Mortality
    Maternal Age
    Health
    Midwifery
    Proxy
    International Classification of Diseases
    Mental Health

    Cite this

    O'Leary, C., Jacoby, P., Bartu, A., D'Antoine, H., & Bower, C. (2013). Maternal alcohol use and sudden infant death syndrome and infant mortality excluding SIDS. Pediatrics, 131(3), e770-e778. https://doi.org/10.1542/peds.2012-1907
    O'Leary, Colleen ; Jacoby, Peter ; Bartu, Anne ; D'Antoine, Heather ; Bower, C. / Maternal alcohol use and sudden infant death syndrome and infant mortality excluding SIDS. In: Pediatrics. 2013 ; Vol. 131, No. 3. pp. e770-e778.
    @article{3ef7ebcad35642b194d33fdf795edd9a,
    title = "Maternal alcohol use and sudden infant death syndrome and infant mortality excluding SIDS",
    abstract = "Background: Improvements in the rate of infant mortality (death in first year of life) have not occurred in recent years. This study investigates the association between maternal alcohol-use disorder and sudden infant death syndrome (SIDS) and infant mortality not classified as SIDS using linked, population-based health and mortality data. Methods: Exposed mothers were identified through the presence of an International Classification of Diseases 9/10 alcohol diagnosis, a proxy for alcohol-use disorder, recorded on health, mental health, and/or drug and alcohol datasets (1983-2005). Comparison mothers without an alcohol diagnosis were frequency matched to exposed mothers on maternal age within maternal race and year of birth of their children. All offspring with their birth recorded on the Midwives Notification System compose the exposed (n = 21 841) and comparison (n= 56 054) cohorts. Cases of SIDS (n = 303) and infant mortality excluding SIDS(n = 598) were identified through linkage with the Western Australian Mortality Register. Analyses were conducted by using Cox regression and results presented as adjusted hazard ratios (aHRs) and 95{\%} confidence intervals (CIs). Results: The highest risk of SIDS occurred when a maternal alcohol diagnosis was recorded during pregnancy (aHR 6.92, 95{\%} CI 4.02-11.90) or within 1 year postpregnancy (aHR 8.61, 95{\%} CI 5.04-14.69). An alcohol diagnosis recorded during pregnancy more than doubled the risk of infant deaths (excluding SIDS) (aHR 2.35, 95{\%} CI 1.45-3.83). Maternal alcohol-use disorder is attributable for at least 16.41{\%} (95{\%} CI 9.73{\%}-23.69{\%}) of SIDS and 3.40{\%} (95{\%} CI 2.28{\%}-4.67{\%}) of infant deaths not classified as SIDS. Conclusions: Maternal alcohol-use disorder is asignificant risk factor for SIDS and infant mortality excluding SIDS.",
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    author = "Colleen O'Leary and Peter Jacoby and Anne Bartu and Heather D'Antoine and C Bower",
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    doi = "10.1542/peds.2012-1907",
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    O'Leary, C, Jacoby, P, Bartu, A, D'Antoine, H & Bower, C 2013, 'Maternal alcohol use and sudden infant death syndrome and infant mortality excluding SIDS', Pediatrics, vol. 131, no. 3, pp. e770-e778. https://doi.org/10.1542/peds.2012-1907

    Maternal alcohol use and sudden infant death syndrome and infant mortality excluding SIDS. / O'Leary, Colleen; Jacoby, Peter; Bartu, Anne; D'Antoine, Heather; Bower, C.

    In: Pediatrics, Vol. 131, No. 3, 03.2013, p. e770-e778.

    Research output: Contribution to journalArticleResearchpeer-review

    TY - JOUR

    T1 - Maternal alcohol use and sudden infant death syndrome and infant mortality excluding SIDS

    AU - O'Leary, Colleen

    AU - Jacoby, Peter

    AU - Bartu, Anne

    AU - D'Antoine, Heather

    AU - Bower, C

    PY - 2013/3

    Y1 - 2013/3

    N2 - Background: Improvements in the rate of infant mortality (death in first year of life) have not occurred in recent years. This study investigates the association between maternal alcohol-use disorder and sudden infant death syndrome (SIDS) and infant mortality not classified as SIDS using linked, population-based health and mortality data. Methods: Exposed mothers were identified through the presence of an International Classification of Diseases 9/10 alcohol diagnosis, a proxy for alcohol-use disorder, recorded on health, mental health, and/or drug and alcohol datasets (1983-2005). Comparison mothers without an alcohol diagnosis were frequency matched to exposed mothers on maternal age within maternal race and year of birth of their children. All offspring with their birth recorded on the Midwives Notification System compose the exposed (n = 21 841) and comparison (n= 56 054) cohorts. Cases of SIDS (n = 303) and infant mortality excluding SIDS(n = 598) were identified through linkage with the Western Australian Mortality Register. Analyses were conducted by using Cox regression and results presented as adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs). Results: The highest risk of SIDS occurred when a maternal alcohol diagnosis was recorded during pregnancy (aHR 6.92, 95% CI 4.02-11.90) or within 1 year postpregnancy (aHR 8.61, 95% CI 5.04-14.69). An alcohol diagnosis recorded during pregnancy more than doubled the risk of infant deaths (excluding SIDS) (aHR 2.35, 95% CI 1.45-3.83). Maternal alcohol-use disorder is attributable for at least 16.41% (95% CI 9.73%-23.69%) of SIDS and 3.40% (95% CI 2.28%-4.67%) of infant deaths not classified as SIDS. Conclusions: Maternal alcohol-use disorder is asignificant risk factor for SIDS and infant mortality excluding SIDS.

    AB - Background: Improvements in the rate of infant mortality (death in first year of life) have not occurred in recent years. This study investigates the association between maternal alcohol-use disorder and sudden infant death syndrome (SIDS) and infant mortality not classified as SIDS using linked, population-based health and mortality data. Methods: Exposed mothers were identified through the presence of an International Classification of Diseases 9/10 alcohol diagnosis, a proxy for alcohol-use disorder, recorded on health, mental health, and/or drug and alcohol datasets (1983-2005). Comparison mothers without an alcohol diagnosis were frequency matched to exposed mothers on maternal age within maternal race and year of birth of their children. All offspring with their birth recorded on the Midwives Notification System compose the exposed (n = 21 841) and comparison (n= 56 054) cohorts. Cases of SIDS (n = 303) and infant mortality excluding SIDS(n = 598) were identified through linkage with the Western Australian Mortality Register. Analyses were conducted by using Cox regression and results presented as adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs). Results: The highest risk of SIDS occurred when a maternal alcohol diagnosis was recorded during pregnancy (aHR 6.92, 95% CI 4.02-11.90) or within 1 year postpregnancy (aHR 8.61, 95% CI 5.04-14.69). An alcohol diagnosis recorded during pregnancy more than doubled the risk of infant deaths (excluding SIDS) (aHR 2.35, 95% CI 1.45-3.83). Maternal alcohol-use disorder is attributable for at least 16.41% (95% CI 9.73%-23.69%) of SIDS and 3.40% (95% CI 2.28%-4.67%) of infant deaths not classified as SIDS. Conclusions: Maternal alcohol-use disorder is asignificant risk factor for SIDS and infant mortality excluding SIDS.

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    KW - alcohol use disorder

    KW - article

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    KW - pregnancy

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    KW - sudden infant death syndrome

    KW - Adult

    KW - Alcoholism

    KW - Cohort Studies

    KW - Female

    KW - Humans

    KW - Infant Mortality

    KW - Infant, Newborn

    KW - Population Surveillance

    KW - Pregnancy

    KW - Prenatal Exposure Delayed Effects

    KW - Sudden Infant Death

    KW - Young Adult

    U2 - 10.1542/peds.2012-1907

    DO - 10.1542/peds.2012-1907

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    JO - Pediatrics

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