Maternal body mass index, excess gestational weight gain, and diabetes are positively associated with neonatal adiposity in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study

on behalf of the PANDORA study research team

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Background: In-utero exposures likely influence the onset and severity of obesity in youth. With increasing rates of type 2 diabetes mellitus (T2DM) and maternal adiposity in pregnancy globally, it is important to assess the impact of these factors on neonatal adipose measures.

    Objectives: To evaluate the contribution of maternal ethnicity, body mass index (BMI), gestational weight gain, and hyperglycaemia to neonatal adiposity.

    Methods: Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) is a longitudinal cohort study of Australian mother and neonate pairs. In this analysis, Indigenous (n = 519) and Europid (n = 358) women were included, of whom 644 had hyperglycaemia (type 2 diabetes [T2DM], diabetes in pregnancy [DIP], or gestational diabetes [GDM]). Associations between maternal ethnicity, hyperglycaemia, BMI and gestational weight gain, and the neonatal outcomes of length, head circumference, sum of skinfolds, total body fat, and percentage body fat were examined. Models were adjusted for maternal age, smoking status, parity, education, neonatal gender, and gestational age.

    Results: Among those with hyperglycaemia in pregnancy, Indigenous women had a higher proportion of T2DM and DIP (36%, 13%) compared with Europid women (4%, 3%). In multivariate analysis, maternal T2DM (compared with no hyperglycaemia), BMI during pregnancy, and excess compared with appropriate gestational weight gain, were significantly associated with greater neonatal measures. DIP was associated with greater sum of skinfolds, total body fat, and percentage body fat. Indigenous ethnicity was associated with greater sum of skinfolds.

    Conclusions: Maternal BMI, excess gestational weight gain, and hyperglycaemia operated as independent factors influencing neonatal adiposity. Interventions addressing these factors are needed to reduce neonatal adiposity.

    Original languageEnglish
    Article numbere12490
    Pages (from-to)1-9
    Number of pages9
    JournalPediatric Obesity
    Volume14
    Issue number4
    Early online date16 Jan 2019
    DOIs
    Publication statusPublished - Apr 2019

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    Pregnancy in Diabetics
    Adiposity
    Hyperglycemia
    Weight Gain
    Body Mass Index
    Type 2 Diabetes Mellitus
    Mothers
    Adipose Tissue
    Pregnancy
    Gestational Diabetes
    Maternal Age
    Parity
    Gestational Age
    Longitudinal Studies
    Diabetes Mellitus
    Cohort Studies
    Multivariate Analysis
    Obesity
    Smoking
    Head

    Cite this

    @article{94f0bcdd389849b0a753c376461f659a,
    title = "Maternal body mass index, excess gestational weight gain, and diabetes are positively associated with neonatal adiposity in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study",
    abstract = "Background: In-utero exposures likely influence the onset and severity of obesity in youth. With increasing rates of type 2 diabetes mellitus (T2DM) and maternal adiposity in pregnancy globally, it is important to assess the impact of these factors on neonatal adipose measures. Objectives: To evaluate the contribution of maternal ethnicity, body mass index (BMI), gestational weight gain, and hyperglycaemia to neonatal adiposity. Methods: Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) is a longitudinal cohort study of Australian mother and neonate pairs. In this analysis, Indigenous (n = 519) and Europid (n = 358) women were included, of whom 644 had hyperglycaemia (type 2 diabetes [T2DM], diabetes in pregnancy [DIP], or gestational diabetes [GDM]). Associations between maternal ethnicity, hyperglycaemia, BMI and gestational weight gain, and the neonatal outcomes of length, head circumference, sum of skinfolds, total body fat, and percentage body fat were examined. Models were adjusted for maternal age, smoking status, parity, education, neonatal gender, and gestational age. Results: Among those with hyperglycaemia in pregnancy, Indigenous women had a higher proportion of T2DM and DIP (36{\%}, 13{\%}) compared with Europid women (4{\%}, 3{\%}). In multivariate analysis, maternal T2DM (compared with no hyperglycaemia), BMI during pregnancy, and excess compared with appropriate gestational weight gain, were significantly associated with greater neonatal measures. DIP was associated with greater sum of skinfolds, total body fat, and percentage body fat. Indigenous ethnicity was associated with greater sum of skinfolds. Conclusions: Maternal BMI, excess gestational weight gain, and hyperglycaemia operated as independent factors influencing neonatal adiposity. Interventions addressing these factors are needed to reduce neonatal adiposity.",
    keywords = "adiposity, diabetes, indigenous, neonatal",
    author = "{on behalf of the PANDORA study research team} and Longmore, {Danielle K.} and Barr, {Elizabeth L.M.} and Lee, {I. Lynn} and Federica Barzi and Marie Kirkwood and Cherie Whitbread and Vanya Hampton and Sian Graham and {Van Dokkum}, Paula and Christine Connors and Boyle, {Jacqueline A.} and Patrick Catalano and Brown, {Alex D.H.} and Kerin O'Dea and Jeremy Oats and McIntyre, {H. David} and Shaw, {Jonathan E.} and Maple-Brown, {Louise J.}",
    year = "2019",
    month = "4",
    doi = "10.1111/ijpo.12490",
    language = "English",
    volume = "14",
    pages = "1--9",
    journal = "Pediatric Obesity",
    issn = "1747-7166",
    publisher = "Wiley-Blackwell",
    number = "4",

    }

    Maternal body mass index, excess gestational weight gain, and diabetes are positively associated with neonatal adiposity in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study. / on behalf of the PANDORA study research team.

    In: Pediatric Obesity, Vol. 14, No. 4, e12490, 04.2019, p. 1-9.

    Research output: Contribution to journalArticleResearchpeer-review

    TY - JOUR

    T1 - Maternal body mass index, excess gestational weight gain, and diabetes are positively associated with neonatal adiposity in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study

    AU - on behalf of the PANDORA study research team

    AU - Longmore, Danielle K.

    AU - Barr, Elizabeth L.M.

    AU - Lee, I. Lynn

    AU - Barzi, Federica

    AU - Kirkwood, Marie

    AU - Whitbread, Cherie

    AU - Hampton, Vanya

    AU - Graham, Sian

    AU - Van Dokkum, Paula

    AU - Connors, Christine

    AU - Boyle, Jacqueline A.

    AU - Catalano, Patrick

    AU - Brown, Alex D.H.

    AU - O'Dea, Kerin

    AU - Oats, Jeremy

    AU - McIntyre, H. David

    AU - Shaw, Jonathan E.

    AU - Maple-Brown, Louise J.

    PY - 2019/4

    Y1 - 2019/4

    N2 - Background: In-utero exposures likely influence the onset and severity of obesity in youth. With increasing rates of type 2 diabetes mellitus (T2DM) and maternal adiposity in pregnancy globally, it is important to assess the impact of these factors on neonatal adipose measures. Objectives: To evaluate the contribution of maternal ethnicity, body mass index (BMI), gestational weight gain, and hyperglycaemia to neonatal adiposity. Methods: Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) is a longitudinal cohort study of Australian mother and neonate pairs. In this analysis, Indigenous (n = 519) and Europid (n = 358) women were included, of whom 644 had hyperglycaemia (type 2 diabetes [T2DM], diabetes in pregnancy [DIP], or gestational diabetes [GDM]). Associations between maternal ethnicity, hyperglycaemia, BMI and gestational weight gain, and the neonatal outcomes of length, head circumference, sum of skinfolds, total body fat, and percentage body fat were examined. Models were adjusted for maternal age, smoking status, parity, education, neonatal gender, and gestational age. Results: Among those with hyperglycaemia in pregnancy, Indigenous women had a higher proportion of T2DM and DIP (36%, 13%) compared with Europid women (4%, 3%). In multivariate analysis, maternal T2DM (compared with no hyperglycaemia), BMI during pregnancy, and excess compared with appropriate gestational weight gain, were significantly associated with greater neonatal measures. DIP was associated with greater sum of skinfolds, total body fat, and percentage body fat. Indigenous ethnicity was associated with greater sum of skinfolds. Conclusions: Maternal BMI, excess gestational weight gain, and hyperglycaemia operated as independent factors influencing neonatal adiposity. Interventions addressing these factors are needed to reduce neonatal adiposity.

    AB - Background: In-utero exposures likely influence the onset and severity of obesity in youth. With increasing rates of type 2 diabetes mellitus (T2DM) and maternal adiposity in pregnancy globally, it is important to assess the impact of these factors on neonatal adipose measures. Objectives: To evaluate the contribution of maternal ethnicity, body mass index (BMI), gestational weight gain, and hyperglycaemia to neonatal adiposity. Methods: Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) is a longitudinal cohort study of Australian mother and neonate pairs. In this analysis, Indigenous (n = 519) and Europid (n = 358) women were included, of whom 644 had hyperglycaemia (type 2 diabetes [T2DM], diabetes in pregnancy [DIP], or gestational diabetes [GDM]). Associations between maternal ethnicity, hyperglycaemia, BMI and gestational weight gain, and the neonatal outcomes of length, head circumference, sum of skinfolds, total body fat, and percentage body fat were examined. Models were adjusted for maternal age, smoking status, parity, education, neonatal gender, and gestational age. Results: Among those with hyperglycaemia in pregnancy, Indigenous women had a higher proportion of T2DM and DIP (36%, 13%) compared with Europid women (4%, 3%). In multivariate analysis, maternal T2DM (compared with no hyperglycaemia), BMI during pregnancy, and excess compared with appropriate gestational weight gain, were significantly associated with greater neonatal measures. DIP was associated with greater sum of skinfolds, total body fat, and percentage body fat. Indigenous ethnicity was associated with greater sum of skinfolds. Conclusions: Maternal BMI, excess gestational weight gain, and hyperglycaemia operated as independent factors influencing neonatal adiposity. Interventions addressing these factors are needed to reduce neonatal adiposity.

    KW - adiposity

    KW - diabetes

    KW - indigenous

    KW - neonatal

    UR - http://www.scopus.com/inward/record.url?scp=85060154860&partnerID=8YFLogxK

    U2 - 10.1111/ijpo.12490

    DO - 10.1111/ijpo.12490

    M3 - Article

    VL - 14

    SP - 1

    EP - 9

    JO - Pediatric Obesity

    JF - Pediatric Obesity

    SN - 1747-7166

    IS - 4

    M1 - e12490

    ER -