Mechanisms for a novel immune evasion strategy in the scabies mite Sarcoptes scabiei

A multigene family of inactivated serine proteases

Deborah Holt, Katja Fischer, G Allen, Danny Wilson, P Wilson, R Slade, Bart Currie, Shelley Walton, David J Kemp

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Parasitic infestation of the skin by the mite Sarcoptes scabiei is a significant problem worldwide, particularly in socially disadvantaged communities. A multigene family of at least 24 homologs of a serine protease allergen have been identified in S. scabiei. Surprisingly, the products of all but one of these genes are predicted to be catalytically inactive, due to mutations at a critical triad of amino acids at the active site. We discuss the possibility that these genes for inactivated proteases have been conserved because they mediate a novel host defense evasion strategy that the mite has evolved as an adaptation to parasitism of the epidermis. The identification of this family, and elucidation of its value to the parasite, may present an unanticipated approach to protective vaccination.
Original languageEnglish
Pages (from-to)1419-1424
Number of pages6
JournalThe Journal of Investigative Dermatology: an international journal for research in cutaneous biology
Volume121
Issue number6
Publication statusPublished - 2003

Fingerprint

Sarcoptes scabiei
Immune Evasion
Scabies
Mites
Serine Proteases
Multigene Family
Genes
Mite Infestations
Vulnerable Populations
Epidermis
Allergens
Catalytic Domain
Skin
Parasites
Vaccination
Peptide Hydrolases
Amino Acids
Mutation

Cite this

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title = "Mechanisms for a novel immune evasion strategy in the scabies mite Sarcoptes scabiei: A multigene family of inactivated serine proteases",
abstract = "Parasitic infestation of the skin by the mite Sarcoptes scabiei is a significant problem worldwide, particularly in socially disadvantaged communities. A multigene family of at least 24 homologs of a serine protease allergen have been identified in S. scabiei. Surprisingly, the products of all but one of these genes are predicted to be catalytically inactive, due to mutations at a critical triad of amino acids at the active site. We discuss the possibility that these genes for inactivated proteases have been conserved because they mediate a novel host defense evasion strategy that the mite has evolved as an adaptation to parasitism of the epidermis. The identification of this family, and elucidation of its value to the parasite, may present an unanticipated approach to protective vaccination.",
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author = "Deborah Holt and Katja Fischer and G Allen and Danny Wilson and P Wilson and R Slade and Bart Currie and Shelley Walton and Kemp, {David J}",
year = "2003",
language = "English",
volume = "121",
pages = "1419--1424",
journal = "The Journal of Investigative Dermatology: an international journal for research in cutaneous biology",
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}

Mechanisms for a novel immune evasion strategy in the scabies mite Sarcoptes scabiei : A multigene family of inactivated serine proteases. / Holt, Deborah; Fischer, Katja; Allen, G; Wilson, Danny; Wilson, P; Slade, R; Currie, Bart; Walton, Shelley; Kemp, David J.

In: The Journal of Investigative Dermatology: an international journal for research in cutaneous biology, Vol. 121, No. 6, 2003, p. 1419-1424.

Research output: Contribution to journalArticleResearchpeer-review

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T2 - A multigene family of inactivated serine proteases

AU - Holt, Deborah

AU - Fischer, Katja

AU - Allen, G

AU - Wilson, Danny

AU - Wilson, P

AU - Slade, R

AU - Currie, Bart

AU - Walton, Shelley

AU - Kemp, David J

PY - 2003

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