@article{2eb4291ba0fb4220832197117e82cc98,
title = "Medical progress: Melioidosis",
abstract = "MELIOIDOSIS, CAUSED BY THE ENVIRONMENTAL GRAM-NEGATIVE BACILlus Burkholderia pseudomallei, is classically characterized by pneumonia and multiple abscesses, with a mortality rate of up to 40%. It is an important cause of community-acquired sepsis in Southeast Asia and northern Australia. Its known global distribution is expanding, a reflection of improvements in diagnostic microbiology and increasing numbers of cases in travelers and returning military personnel (Fig. 1). 1,2 A locally acquired case of melioidosis was recently described in the United States. 3 B. pseudomallei has been classified by the Centers for Disease Control and Prevention as a category B bioterrorism agent, resulting in increased research and understanding of melioidosis. This review considers recent developments in pathogenesis, diagnostics, and treatment.",
keywords = "amoxicillin plus clavulanic acid, ampicillin, bacterial vaccine, ceftazidime, cephalosporin derivative, cotrimoxazole, ertapenem, gentamicin, imipenem, meropenem, nucleotide binding oligomerization domain like receptor, penicillin G, polymyxin, streptomycin, sulfamethoxazole, tigecycline, tobramycin, toll like receptor, trimethoprim, antiinfective agent, virulence factor, antibiotic resistance, bacterial genome, bacterial virulence, Burkholderia pseudomallei, clinical feature, disease association, genome analysis, geographic distribution, host resistance, human, incidence, infection prevention, melioidosis, molecular pathology, nonhuman, pattern recognition, priority journal, review, genetics, microbiology, pathogenicity, Anti-Bacterial Agents, Humans, Melioidosis, Trimethoprim-Sulfamethoxazole Combination, Virulence Factors",
author = "Wiersinga, {W. Joost} and Currie, {Bart J.} and Peacock, {Sharon J.}",
year = "2012",
doi = "10.1056/NEJMra1204699",
language = "English",
volume = "367",
pages = "1035--1044",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachusetts Medical Society",
number = "11",
}
