Melioidosis: An Australian Perspective

Simon Smith; Joshua Hanson; Bart Currie

doi:10.3390/books978-3-03897-743-8

Melioidosis: An Australian Perspective

Simon Smith, Joshua Hanson, Bart Currie

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Burkholderia pseudomallei is endemic in northern Australia, with cases of melioidosis most commonly occurring during the wet season in individuals with diabetes, hazardous alcohol use, and chronic kidney disease. Pneumonia is the most common presentation and the majority of patients are bacteraemic -however, infection may involve almost any organ, with the skin and soft tissues, genitourinary system, visceral organs, and bone and joints affected most commonly. Central nervous system involvement is rarer, but has a high attributable mortality. Increased awareness of the disease amongst healthcare providers, ready access to appropriate antibiotic therapy and high-quality intensive care services has resulted in a sharp decline in the case fatality rate over the last 20 years. Further improvement in clinical outcomes will require a greater understanding of the disease's pathophysiology, its optimal management, and more effective strategies for its prevention.

Original language	English
Title of host publication	Global Burden and Challenges of Melioidosis
Editors	Direk Limmathurotsakul, David Dance
Publisher	Multidisciplinary Digital Publishing Institute (MDPI)
Pages	13-23
Number of pages	11
ISBN (Electronic)	978-3-03897-743-8
ISBN (Print)	978-3-03897-742-1
DOIs	https://doi.org/10.3390/books978-3-03897-743-8
Publication status	Published - Mar 2019

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Smith, S., Hanson, J., & Currie, B. (2019). Melioidosis: An Australian Perspective. In D. Limmathurotsakul, & D. Dance (Eds.), Global Burden and Challenges of Melioidosis (pp. 13-23). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/books978-3-03897-743-8

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abstract = "Burkholderia pseudomallei is endemic in northern Australia, with cases of melioidosis most commonly occurring during the wet season in individuals with diabetes, hazardous alcohol use, and chronic kidney disease. Pneumonia is the most common presentation and the majority of patients are bacteraemic -however, infection may involve almost any organ, with the skin and soft tissues, genitourinary system, visceral organs, and bone and joints affected most commonly. Central nervous system involvement is rarer, but has a high attributable mortality. Increased awareness of the disease amongst healthcare providers, ready access to appropriate antibiotic therapy and high-quality intensive care services has resulted in a sharp decline in the case fatality rate over the last 20 years. Further improvement in clinical outcomes will require a greater understanding of the disease's pathophysiology, its optimal management, and more effective strategies for its prevention.",

author = "Simon Smith and Joshua Hanson and Bart Currie",

note = "This book is a printed edition of the Special Issue Global Burden and Challenges of Melioidosis that was published in TropicalMed.",

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N2 - Burkholderia pseudomallei is endemic in northern Australia, with cases of melioidosis most commonly occurring during the wet season in individuals with diabetes, hazardous alcohol use, and chronic kidney disease. Pneumonia is the most common presentation and the majority of patients are bacteraemic -however, infection may involve almost any organ, with the skin and soft tissues, genitourinary system, visceral organs, and bone and joints affected most commonly. Central nervous system involvement is rarer, but has a high attributable mortality. Increased awareness of the disease amongst healthcare providers, ready access to appropriate antibiotic therapy and high-quality intensive care services has resulted in a sharp decline in the case fatality rate over the last 20 years. Further improvement in clinical outcomes will require a greater understanding of the disease's pathophysiology, its optimal management, and more effective strategies for its prevention.

AB - Burkholderia pseudomallei is endemic in northern Australia, with cases of melioidosis most commonly occurring during the wet season in individuals with diabetes, hazardous alcohol use, and chronic kidney disease. Pneumonia is the most common presentation and the majority of patients are bacteraemic -however, infection may involve almost any organ, with the skin and soft tissues, genitourinary system, visceral organs, and bone and joints affected most commonly. Central nervous system involvement is rarer, but has a high attributable mortality. Increased awareness of the disease amongst healthcare providers, ready access to appropriate antibiotic therapy and high-quality intensive care services has resulted in a sharp decline in the case fatality rate over the last 20 years. Further improvement in clinical outcomes will require a greater understanding of the disease's pathophysiology, its optimal management, and more effective strategies for its prevention.

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