Melioidosis

An Australian Perspective

Simon Smith, Joshua Hanson, Bart Currie

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Abstract

Burkholderia pseudomallei is endemic in northern Australia, with cases of melioidosis most commonly occurring during the wet season in individuals with diabetes, hazardous alcohol use, and chronic kidney disease. Pneumonia is the most common presentation and the majority of patients are bacteraemic -however, infection may involve almost any organ, with the skin and soft tissues, genitourinary system, visceral organs, and bone and joints affected most commonly. Central nervous system involvement is rarer, but has a high attributable mortality. Increased awareness of the disease amongst healthcare providers, ready access to appropriate antibiotic therapy and high-quality intensive care services has resulted in a sharp decline in the case fatality rate over the last 20 years. Further improvement in clinical outcomes will require a greater understanding of the disease's pathophysiology, its optimal management, and more effective strategies for its prevention.
Original languageEnglish
Title of host publicationGlobal Burden and Challenges of Melioidosis
EditorsDirek Limmathurotsakul, David Dance
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
Pages13-23
Number of pages11
ISBN (Electronic)978-3-03897-743-8
ISBN (Print)978-3-03897-742-1
DOIs
Publication statusPublished - Mar 2019

Fingerprint

Melioidosis
Burkholderia pseudomallei
Urogenital System
Mortality
Quality of Health Care
Critical Care
Chronic Renal Insufficiency
Health Personnel
Pneumonia
Central Nervous System
Joints
Alcohols
Anti-Bacterial Agents
Bone and Bones
Skin
Infection
Therapeutics

Cite this

Smith, S., Hanson, J., & Currie, B. (2019). Melioidosis: An Australian Perspective. In D. Limmathurotsakul, & D. Dance (Eds.), Global Burden and Challenges of Melioidosis (pp. 13-23). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/books978-3-03897-743-8
Smith, Simon ; Hanson, Joshua ; Currie, Bart. / Melioidosis : An Australian Perspective. Global Burden and Challenges of Melioidosis. editor / Direk Limmathurotsakul ; David Dance. Multidisciplinary Digital Publishing Institute (MDPI), 2019. pp. 13-23
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Smith, S, Hanson, J & Currie, B 2019, Melioidosis: An Australian Perspective. in D Limmathurotsakul & D Dance (eds), Global Burden and Challenges of Melioidosis. Multidisciplinary Digital Publishing Institute (MDPI), pp. 13-23. https://doi.org/10.3390/books978-3-03897-743-8

Melioidosis : An Australian Perspective. / Smith, Simon; Hanson, Joshua; Currie, Bart.

Global Burden and Challenges of Melioidosis. ed. / Direk Limmathurotsakul; David Dance. Multidisciplinary Digital Publishing Institute (MDPI), 2019. p. 13-23.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

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AB - Burkholderia pseudomallei is endemic in northern Australia, with cases of melioidosis most commonly occurring during the wet season in individuals with diabetes, hazardous alcohol use, and chronic kidney disease. Pneumonia is the most common presentation and the majority of patients are bacteraemic -however, infection may involve almost any organ, with the skin and soft tissues, genitourinary system, visceral organs, and bone and joints affected most commonly. Central nervous system involvement is rarer, but has a high attributable mortality. Increased awareness of the disease amongst healthcare providers, ready access to appropriate antibiotic therapy and high-quality intensive care services has resulted in a sharp decline in the case fatality rate over the last 20 years. Further improvement in clinical outcomes will require a greater understanding of the disease's pathophysiology, its optimal management, and more effective strategies for its prevention.

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Smith S, Hanson J, Currie B. Melioidosis: An Australian Perspective. In Limmathurotsakul D, Dance D, editors, Global Burden and Challenges of Melioidosis. Multidisciplinary Digital Publishing Institute (MDPI). 2019. p. 13-23 https://doi.org/10.3390/books978-3-03897-743-8