Melioidosis: An Australian perspective

Simon Smith, Josh Hanson, Bart J. Currie

Research output: Contribution to journalReview articlepeer-review

Abstract

Burkholderia pseudomallei is endemic in northern Australia, with cases of melioidosis most commonly occurring during the wet season in individuals with diabetes, hazardous alcohol use, and chronic kidney disease. Pneumonia is the most common presentation and the majority of patients are bacteraemic—however, infection may involve almost any organ, with the skin and soft tissues, genitourinary system, visceral organs, and bone and joints affected most commonly. Central nervous system involvement is rarer, but has a high attributable mortality. Increased awareness of the disease amongst healthcare providers, ready access to appropriate antibiotic therapy and high-quality intensive care services has resulted in a sharp decline in the case fatality rate over the last 20 years. Further improvement in clinical outcomes will require a greater understanding of the disease's pathophysiology, its optimal management, and more effective strategies for its prevention.

Original languageEnglish
Article number27
Number of pages11
JournalTropical Medicine and Infectious Disease
Volume3
Issue number1
DOIs
Publication statusPublished - 1 Mar 2018

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