Melioidosis and glanders

    Research output: Contribution to specialist publicationSpecial issue

    Abstract

    ◊ Melioidosis is characterised by fever, pneumonia, and abscesses, although there is a spectrum of severity from mild, localised infections to disseminated infection causing rapidly fatal sepsis.Glanders is uncommon in humans.

    ◊ Diagnosis requires a high index of suspicion from the clinical presentation, and must be confirmed by culture of B pseudomallei (or B mallei).
    ◊ Initial intensive intravenous antibiotic treatmentis the mainstay oftherapy in most patients and may be required for weeks, depending on clinical circumstances. This is followed by a minimum of 3 months of oral eradication therapy to reduce the risk of relapse.

    ◊ Mortality associated with melioidosis is still up to 50% in many endemic regions, but as low as 10% if there is access to timely diagnosis, appropriate antibiotics, and state-of-the-art intensive supportive care.
    Original languageEnglish
    Pages1-39
    Number of pages39
    Specialist publicationBMJ Best Practice
    Publication statusPublished - 2 Nov 2016

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