@article{a31f70a8a73642deb0a9e3f001938b06,
title = "Melioidosis and the kidney",
abstract = "Melioidosis, caused by the saprophytic soil and freshwater Gram-negative aerobic bacillus Burkholderia pseudomallei, is classically characterized by pneumonia, sometimes with multiple organ abscesses, usually in patients with defined risk factors and with a mortality rate of up to 40%. It is a major cause of community-Acquired sepsis in Southeast Asia and tropical northern Australia with an expanding global geographical distribution. It is increasingly recognized as an opportunistic infectious disease of importance to physicians, who may need to suspect it in at-risk patients that may come from or visit endemic areas, and could be fatal if treated late or inappropriately. Mortality could be prevented by early institution of specific antimicrobial therapy. Epidemiology, clinical features, overall management, and aspects of melioidosis particularly relevant to kidney disease and immunosuppression are discussed in this review. This in-depth review on melioidosis may stimulate attention for Asian countries on this easy to be neglected infectious disease. The importance also relies on the fact that mortality can be prevented by early institution of specific antimicrobial therapy. ",
keywords = "adenosine triphosphate, calcium, ceftazidime, cotrimoxazole, cyclosporin, meropenem, methotrexate, prednisolone, abdominal abscess, acute kidney failure, Africa, agricultural worker, alcohol consumption, antimicrobial therapy, Australia, bacteremia, bacterial arthritis, bacterial transmission, China, chronic kidney disease, chronic lung disease, community acquired pneumonia, diabetes mellitus, disease course, disease predisposition, environmental factor, eradication therapy, gardening, human, immunofluorescence microscopy, immunosuppressive treatment, incidence, incubation time, India, infection rate, inhalation, innate immunity, kidney disease, Korea, landscaping, macrophage function, Madagascar, Mauritius, melioidosis, neutrophil chemotaxis, nonhuman, occupational exposure, osteomyelitis, priority journal, respiratory burst, review, serology, skin infection, Southeast Asia, Sri Lanka, Taiwan, Thailand, throat culture, urogenital tract infection, water contamination, Western Hemisphere, Acute Kidney Injury, Anti-Infective Agents, Burkholderia pseudomallei, Comorbidity, Endemic Diseases, Granulocyte Colony-Stimulating Factor, Humans, Immunosuppressive Agents, Melioidosis, Prognosis, Recombinant Proteins, Renal Insufficiency, Chronic, Risk Factors",
author = "Z Jabbar and Bart Currie",
year = "2013",
month = mar,
doi = "10.1111/nep.12024",
language = "English",
volume = "18",
pages = "169--175",
journal = "Nephrology",
issn = "1320-5358",
publisher = "Wiley-Blackwell",
number = "3",
}