Melioidosis in a rural community of Western Province, Papua New Guinea

Jeffrey Warner, D Pelowa, Bart Currie, R Hirst

    Research output: Contribution to journalArticle

    Abstract

    A prospective study was conducted to determine the significance of melioidosis in the Balimo district of Western Province, Papua New Guinea. During 1998, after the establishment of laboratory procedures and increasing local clinical awareness, the disease was found in 1.8% (95% CI 0.37-5.1%) of individuals presenting with fever refractory to standard treatment. The clinical incidence was 20.0 per 100 000 population (95% CI 12.2-30.9). The median age of culture-confirmed cases was 9.5 years (interquartile range 8.3-14.8 years). The seroprevalence of 747 community children in the region tested was 8.2% (95% CI 6.2-10.4%). Most individuals presented during the rainy season with a febrile disease refractory to standard treatment, sometimes mimicking tuberculosis. Some family clustering was apparent. All patients with bacteraemic melioidosis died, but treatment with the available conventional therapies of chloramphenicol, co-trimoxazole or doxycycline resulted in survival and cure in six patients with subacute/localised melioidosis. Further studies are needed to ascertain the local epidemiology and why children appear particularly at risk, as well as to establish the true extent of melioidosis in Papua New Guinea. � 2007 Royal Society of Tropical Medicine and Hygiene.
    Original languageEnglish
    Pages (from-to)809-813
    Number of pages5
    JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
    Volume101
    Issue number8
    Publication statusPublished - 2007

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