Methicillin-resistant Staphylococcus aureus acquisition in healthcare workers with cystic fibrosis: A retrospective cross-sectional study

Michelle E. Wood; Laura J. Sherrard; Kay A. Ramsay; Stephanie T. Yerkovich; David W Reid; Timothy J. Kidd; Scott C. Bell

doi:10.1186/s12890-016-0243-z

Methicillin-resistant Staphylococcus aureus acquisition in healthcare workers with cystic fibrosis: A retrospective cross-sectional study

Michelle E. Wood, Laura J. Sherrard, Kay A. Ramsay, Stephanie T. Yerkovich, David W Reid, Timothy J. Kidd, Scott C. Bell

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Abstract

Background: People with cystic fibrosis (CF) may work in healthcare settings risking nosocomial pathogen acquisition. The aim of this study was to determine the incidence of methicillin-resistant Staphylococcus aureus (MRSA) infection in adult healthcare workers with CF (HCWcf).

Methods: Data was collected in this observational study on MRSA acquisition from 405 CF patients attending an adult CF centre in Australia between 2001-2012. Demographic and clinical characteristics were compared between HCWcf and non-HCWcf. A sub-analysis was subsequently performed to compare demographic and clinical characteristics between those patients (HCWcf versus non-HCWcf) that acquired MRSA. We also investigated rates of chronic MRSA infection and the outcome of eradication treatment in HCWcf.

Results: A higher proportion of HCWcf acquired MRSA [n = 10/21] compared to non-HCWcf [n = 40/255] (P <0.001). The odds of MRSA acquisition were 8.4 (95 % CI, 3.0 - 23.4) times greater in HCWcf than non-HCWcf. HCWcf with MRSA were older (P = 0.02) and had better lung function (P = 0.009), yet hospitalisation rates were similar compared to non-HCWcf with MRSA. Chronic MRSA infection developed in 36/50 CF patients (HCWcf, n = 6; non-HCWcf, n = 30), with eradication therapy achieved in 5/6 (83 %) HCWcf.

Conclusions: The rate of MRSA incidence was highest in HCWcf and the workplace is a possible source of acquisition. Vocational guidance should include the potential for MRSA acquisition for CF patients considering healthcare professions.

Original language	English
Article number	78
Pages (from-to)	1-7
Number of pages	7
Journal	BMC Pulmonary Medicine
Volume	16
DOIs	https://doi.org/10.1186/s12890-016-0243-z
Publication status	Published - 11 May 2016
Externally published	Yes

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10060320-oaFinal published version, 543 KBLicence: CC BY

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@article{106921e49e5e4669ac2d12eab6df9017,

title = "Methicillin-resistant Staphylococcus aureus acquisition in healthcare workers with cystic fibrosis: A retrospective cross-sectional study",

abstract = "Background: People with cystic fibrosis (CF) may work in healthcare settings risking nosocomial pathogen acquisition. The aim of this study was to determine the incidence of methicillin-resistant Staphylococcus aureus (MRSA) infection in adult healthcare workers with CF (HCWcf). Methods: Data was collected in this observational study on MRSA acquisition from 405 CF patients attending an adult CF centre in Australia between 2001-2012. Demographic and clinical characteristics were compared between HCWcf and non-HCWcf. A sub-analysis was subsequently performed to compare demographic and clinical characteristics between those patients (HCWcf versus non-HCWcf) that acquired MRSA. We also investigated rates of chronic MRSA infection and the outcome of eradication treatment in HCWcf. Results: A higher proportion of HCWcf acquired MRSA [n = 10/21] compared to non-HCWcf [n = 40/255] (P <0.001). The odds of MRSA acquisition were 8.4 (95 % CI, 3.0 - 23.4) times greater in HCWcf than non-HCWcf. HCWcf with MRSA were older (P = 0.02) and had better lung function (P = 0.009), yet hospitalisation rates were similar compared to non-HCWcf with MRSA. Chronic MRSA infection developed in 36/50 CF patients (HCWcf, n = 6; non-HCWcf, n = 30), with eradication therapy achieved in 5/6 (83 %) HCWcf. Conclusions: The rate of MRSA incidence was highest in HCWcf and the workplace is a possible source of acquisition. Vocational guidance should include the potential for MRSA acquisition for CF patients considering healthcare professions.",

keywords = "Cystic fibrosis, Employment, Incidence, MRSA, Nosocomial infection",

author = "Wood, {Michelle E.} and Sherrard, {Laura J.} and Ramsay, {Kay A.} and Yerkovich, {Stephanie T.} and Reid, {David W} and Kidd, {Timothy J.} and Bell, {Scott C.}",

year = "2016",

month = may,

day = "11",

doi = "10.1186/s12890-016-0243-z",

language = "English",

volume = "16",

pages = "1--7",

journal = "BMC Pulmonary Medicine",

issn = "1471-2466",

publisher = "BioMed Central",

}

TY - JOUR

T1 - Methicillin-resistant Staphylococcus aureus acquisition in healthcare workers with cystic fibrosis

T2 - A retrospective cross-sectional study

AU - Wood, Michelle E.

AU - Sherrard, Laura J.

AU - Ramsay, Kay A.

AU - Yerkovich, Stephanie T.

AU - Reid, David W

AU - Kidd, Timothy J.

AU - Bell, Scott C.

PY - 2016/5/11

Y1 - 2016/5/11

N2 - Background: People with cystic fibrosis (CF) may work in healthcare settings risking nosocomial pathogen acquisition. The aim of this study was to determine the incidence of methicillin-resistant Staphylococcus aureus (MRSA) infection in adult healthcare workers with CF (HCWcf). Methods: Data was collected in this observational study on MRSA acquisition from 405 CF patients attending an adult CF centre in Australia between 2001-2012. Demographic and clinical characteristics were compared between HCWcf and non-HCWcf. A sub-analysis was subsequently performed to compare demographic and clinical characteristics between those patients (HCWcf versus non-HCWcf) that acquired MRSA. We also investigated rates of chronic MRSA infection and the outcome of eradication treatment in HCWcf. Results: A higher proportion of HCWcf acquired MRSA [n = 10/21] compared to non-HCWcf [n = 40/255] (P <0.001). The odds of MRSA acquisition were 8.4 (95 % CI, 3.0 - 23.4) times greater in HCWcf than non-HCWcf. HCWcf with MRSA were older (P = 0.02) and had better lung function (P = 0.009), yet hospitalisation rates were similar compared to non-HCWcf with MRSA. Chronic MRSA infection developed in 36/50 CF patients (HCWcf, n = 6; non-HCWcf, n = 30), with eradication therapy achieved in 5/6 (83 %) HCWcf. Conclusions: The rate of MRSA incidence was highest in HCWcf and the workplace is a possible source of acquisition. Vocational guidance should include the potential for MRSA acquisition for CF patients considering healthcare professions.

AB - Background: People with cystic fibrosis (CF) may work in healthcare settings risking nosocomial pathogen acquisition. The aim of this study was to determine the incidence of methicillin-resistant Staphylococcus aureus (MRSA) infection in adult healthcare workers with CF (HCWcf). Methods: Data was collected in this observational study on MRSA acquisition from 405 CF patients attending an adult CF centre in Australia between 2001-2012. Demographic and clinical characteristics were compared between HCWcf and non-HCWcf. A sub-analysis was subsequently performed to compare demographic and clinical characteristics between those patients (HCWcf versus non-HCWcf) that acquired MRSA. We also investigated rates of chronic MRSA infection and the outcome of eradication treatment in HCWcf. Results: A higher proportion of HCWcf acquired MRSA [n = 10/21] compared to non-HCWcf [n = 40/255] (P <0.001). The odds of MRSA acquisition were 8.4 (95 % CI, 3.0 - 23.4) times greater in HCWcf than non-HCWcf. HCWcf with MRSA were older (P = 0.02) and had better lung function (P = 0.009), yet hospitalisation rates were similar compared to non-HCWcf with MRSA. Chronic MRSA infection developed in 36/50 CF patients (HCWcf, n = 6; non-HCWcf, n = 30), with eradication therapy achieved in 5/6 (83 %) HCWcf. Conclusions: The rate of MRSA incidence was highest in HCWcf and the workplace is a possible source of acquisition. Vocational guidance should include the potential for MRSA acquisition for CF patients considering healthcare professions.

KW - Cystic fibrosis

KW - Employment

KW - Incidence

KW - MRSA

KW - Nosocomial infection

UR - http://www.scopus.com/inward/record.url?scp=84968884594&partnerID=8YFLogxK

U2 - 10.1186/s12890-016-0243-z

DO - 10.1186/s12890-016-0243-z

M3 - Article

AN - SCOPUS:84968884594

VL - 16

SP - 1

EP - 7

JO - BMC Pulmonary Medicine

JF - BMC Pulmonary Medicine

SN - 1471-2466

M1 - 78

ER -

Methicillin-resistant Staphylococcus aureus acquisition in healthcare workers with cystic fibrosis: A retrospective cross-sectional study

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