Methodology and measurement of the effectiveness of Haemophilus influenzae type b vaccine: Systematic review

Rosalyn O'Loughlin, Karen Edmond, Punam Mangtani, Adam Cohen, Sharmila Shetty, R hajjeh, Edward (Kim) MULHOLLAND

    Research output: Contribution to journalArticle

    Abstract

    The use of the highly effective Haemophilus influenzae type b (Hib) conjugate vaccine has increased globally. We review the benefits and limitations of studies measuring Hib vaccine effectiveness (VE). We critically examine the case–control approach by assessing the similarities and differences in methodology and findings and discuss the need for future Hib VE studies. In the absence of good surveillance data, vaccine effectiveness studies can play an important role, particularly with the increasing use of pneumococcal vaccine that has not been well tested under field conditions in less developed countries. However, the effectiveness of Hib vaccine has been well documented so the need for future VE Hib studies is minimal.
    Original languageEnglish
    Pages (from-to)6128-6136
    Number of pages9
    JournalVaccine
    Volume28
    Issue number38
    DOIs
    Publication statusPublished - 31 Aug 2010

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