Methods to assess the impact of mass oral cholera vaccination campaigns under real field conditions

Jacqueline Deen, Mohammad Ali, David Sack

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    Abstract

    There is increasing interest to use oral cholera vaccination as an additional strategy to water and sanitation interventions against endemic and epidemic cholera. There are two internationally-available and WHO-prequalified oral cholera vaccines: an inactivated vaccine containing killed whole-cells of V. cholerae O1 with recombinant cholera toxin B-subunit (WC/rBS) and a bivalent inactivated vaccine containing killed whole cells of V. cholerae O1 and V. cholerae O139 (BivWC). The efficacy, effectiveness, direct and indirect (herd) protection conferred by WC/rBS and BivWC are well established. Yet governments may need local evidence of vaccine impact to justify and scale-up mass oral cholera vaccination campaigns. We discuss various approaches to assess oral cholera vaccine protection, which may be useful to policymakers and public health workers considering deployment and evaluation of the vaccine. � 2014 Deen et al.
    Original languageEnglish
    Article numbere88139
    Pages (from-to)1-7
    Number of pages7
    JournalPLoS One
    Volume9
    Issue number2
    DOIs
    Publication statusPublished - 2014

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