We used whole-genome sequencing to evaluate 69 independent colonies of Burkholderia pseudomallei isolated from seven body sites of a patient with acute disseminated melioidosis. Fourteen closely related genotypes were found, providing evidence for the rapid in vivo diversification of B. pseudomallei after inoculation and systemic spread.
Limmathurotsakul, D., Holden, M., Coupland, P., Price, E., Chantratitia, N., Wuthiekanun, V., ... Peacock, S. J. (2014). Microevolution of Burkholderia pseudomallei during an acute infection. Journal of Clinical Microbiology, 52(9), 3418-3421. https://doi.org/10.1128/JCM.01219-14