Microevolution of Burkholderia pseudomallei during an acute infection

Direk Limmathurotsakul, Matthew Holden, Paul Coupland, Erin Price, Narisara Chantratitia, Vanaporn Wuthiekanun, Premjit Amornchai, Julian Parkhill, Sharon J Peacock

    Research output: Contribution to journalComment/debate


    We used whole-genome sequencing to evaluate 69 independent colonies of Burkholderia pseudomallei isolated from seven body sites of a patient with acute disseminated melioidosis. Fourteen closely related genotypes were found, providing evidence for the rapid in vivo diversification of B. pseudomallei after inoculation and systemic spread.
    Original languageEnglish
    Pages (from-to)3418-3421
    Number of pages4
    JournalJournal of Clinical Microbiology
    Issue number9
    Publication statusPublished - 2014


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