Depression is a condition that affects millions of people worldwide and is the highest cause of disease burden for women. Postnatal depression affects up to 25% of all childbearing women; however, its prevalence is often under-detected and under-diagnosed. Early screening and early intervention are integral in the prevention of postnatal depression. Preventive interventions focus on the efficacy of omega-3 supplements, physical activity and placentophagy practices. However, there is promising evidence regarding the efficacy of antidepressant therapy, increased social support, and technological-based psychological interventions in the prevention of postnatal depression.