Molecular characterisation of pneumococcal serotype 16F: Established predominant carriage and otitis media serotype in the 7vPCV era

Robyn Marsh, Heidi Smith-Vaughan, Jemima Beissbarth, Kim Hare, M KENNEDY, C WIGGER, G MELLON, E STUBBS, J Gadil, A Pettit, Grant Mackenzie, P Tipakalippa, Peter Morris, Amanda Leach

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Young Australian Aboriginal children in remote communities experience very high rates of pneumococcal carriage and otitis media. Prior to introduction of the 7-valent pneumococcal conjugate vaccine (7vPCV, Prevenar), serotype 16F was an important type found in nasal and ear discharge swabs. Since commencement of pneumococcal immunisation for Aboriginal infants in 2001, 16F has become the predominant established serotype in carriage and otitis media in young Aboriginal children. BOX typing and multi-locus sequence typing revealed a diverse population of serotype 16F strains, and evidence of potential capsule switching from a vaccine serotype 4 to a serotype 16F. � 2006 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)2434-2436
Number of pages3
JournalVaccine
Volume25
Issue number13
Publication statusPublished - 2007

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