Molecular markers for malaria genetic epidemiology: Progress and pitfalls

Shazia Ruybal-Pesántez, Kirsty McCann, Jessy Vibin, Sasha Siegel, Sarah Auburn, Alyssa E. Barry

Research output: Contribution to journalReview articlepeer-review

Abstract

Over recent years, progress in molecular markers for genotyping malaria parasites has enabled informative studies of epidemiology and transmission dynamics. Results have highlighted the value of these tools for surveillance to support malaria control and elimination strategies. There are many different types and panels of markers available for malaria parasite genotyping, and for end users, the nuances of these markers with respect to ‘use case’, resolution, and accuracy, are not well defined. This review clarifies issues surrounding different molecular markers and their application to malaria control and elimination. We describe available marker panels, use cases, implications for different transmission settings, limitations, access, cost, and data accuracy. The information provided can be used as a guide for molecular epidemiology and surveillance of malaria.

Original languageEnglish
Pages (from-to)1-17
Number of pages17
JournalTrends in Parasitology
Early online date2023
DOIs
Publication statusE-pub ahead of print - 2023

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