Abstract
Over recent years, progress in molecular markers for genotyping malaria parasites has enabled informative studies of epidemiology and transmission dynamics. Results have highlighted the value of these tools for surveillance to support malaria control and elimination strategies. There are many different types and panels of markers available for malaria parasite genotyping, and for end users, the nuances of these markers with respect to ‘use case’, resolution, and accuracy, are not well defined. This review clarifies issues surrounding different molecular markers and their application to malaria control and elimination. We describe available marker panels, use cases, implications for different transmission settings, limitations, access, cost, and data accuracy. The information provided can be used as a guide for molecular epidemiology and surveillance of malaria.
| Original language | English |
|---|---|
| Pages (from-to) | 147 - 163 |
| Number of pages | 17 |
| Journal | Trends in Parasitology |
| Volume | 40 |
| Issue number | 2 |
| Early online date | 2023 |
| DOIs | |
| Publication status | Published - Feb 2024 |
Bibliographical note
Funding Information:This review was made possible through ongoing support from the National Health and Medical Research Council of Australia Project Grants GNT1027108 , GNT1005653 , GNT1163420 , and GNT1161066 to A.E.B. S.R-P. acknowledges funding from the Medical Research Council (MRC) Centre for Global Infectious Disease Analysis (reference MR/X020258/1), funded by the UK MRC. This UK funded award is carried out in the frame of the Global Health EDCTP3 Joint Undertaking. S.A. is supported by the Bill and Melinda Gates Foundation ( INV-043618 ) and the National Health and Medical Research Council of Australia ( GNT2001083 ). The authors acknowledge the Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council of Australia Independent Research Institute Infrastructure Support Scheme (IRIISS).
Funding Information:
This review was made possible through ongoing support from the National Health and Medical Research Council of Australia Project Grants GNT1027108, GNT1005653, GNT1163420, and GNT1161066 to A.E.B. S.R-P. acknowledges funding from the Medical Research Council (MRC) Centre for Global Infectious Disease Analysis (reference MR/X020258/1), funded by the UK MRC. This UK funded award is carried out in the frame of the Global Health EDCTP3 Joint Undertaking. S.A. is supported by the Bill and Melinda Gates Foundation (INV-043618) and the National Health and Medical Research Council of Australia (GNT2001083). The authors acknowledge the Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council of Australia Independent Research Institute Infrastructure Support Scheme (IRIISS). The authors declare no competing interests.
Publisher Copyright:
© 2023 Elsevier Ltd
