Molecular typing of Streptococcus pyogenes from remote Aboriginal communities where rheumatic fever is common and pyoderma is the predominant streptococcal infection

Malcolm McDonald, R TOWERS, Peter Fagan, Jonathan Carapetis, Bart Currie

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Aboriginal Australians in remote communities have high rates of rheumatic heart disease (RHD); yet pharyngitis is reportedly rare whilst pyoderma is common. Some strains of group A streptococci (GAS) have preference for the throat and others for the skin depending on M protein type. A study in three remote communities provided 350 GAS isolates for emm sequence typing, 244 were also emm pattern typed. There was 100% correlation between emm sequence and pattern type. Patterns D and E (non-throat tropic) made up 71% of throat and 87% of skin isolates although patterns A-C (throat tropic) were more common in the throat than the skin (RR 2.3, 95% CI 1.4 - 3.8) whilst the opposite was found for pattern D (RR 2.2, 95% CI 1.7 - 3.0). Pattern E favoured the throat (RR 1.4, 95% CI 1.1 - 1.8). Where environmental factors predispose to skin infection, emm pattern types D and E prevail, whatever the recovery site. � 2007 Cambridge University Press.
Original languageEnglish
Pages (from-to)1398-1405
Number of pages8
JournalEpidemiology and Infection
Volume135
Issue number8
Publication statusPublished - 2007

Fingerprint

Pyoderma
Molecular Typing
Streptococcal Infections
Rheumatic Fever
Streptococcus pyogenes
Pharynx
Skin
Streptococcus
Rheumatic Heart Disease
Pharyngitis
Infection
Proteins

Cite this

McDonald, Malcolm ; TOWERS, R ; Fagan, Peter ; Carapetis, Jonathan ; Currie, Bart. / Molecular typing of Streptococcus pyogenes from remote Aboriginal communities where rheumatic fever is common and pyoderma is the predominant streptococcal infection. In: Epidemiology and Infection. 2007 ; Vol. 135, No. 8. pp. 1398-1405.
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abstract = "Aboriginal Australians in remote communities have high rates of rheumatic heart disease (RHD); yet pharyngitis is reportedly rare whilst pyoderma is common. Some strains of group A streptococci (GAS) have preference for the throat and others for the skin depending on M protein type. A study in three remote communities provided 350 GAS isolates for emm sequence typing, 244 were also emm pattern typed. There was 100{\%} correlation between emm sequence and pattern type. Patterns D and E (non-throat tropic) made up 71{\%} of throat and 87{\%} of skin isolates although patterns A-C (throat tropic) were more common in the throat than the skin (RR 2.3, 95{\%} CI 1.4 - 3.8) whilst the opposite was found for pattern D (RR 2.2, 95{\%} CI 1.7 - 3.0). Pattern E favoured the throat (RR 1.4, 95{\%} CI 1.1 - 1.8). Where environmental factors predispose to skin infection, emm pattern types D and E prevail, whatever the recovery site. � 2007 Cambridge University Press.",
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McDonald, M, TOWERS, R, Fagan, P, Carapetis, J & Currie, B 2007, 'Molecular typing of Streptococcus pyogenes from remote Aboriginal communities where rheumatic fever is common and pyoderma is the predominant streptococcal infection', Epidemiology and Infection, vol. 135, no. 8, pp. 1398-1405.

Molecular typing of Streptococcus pyogenes from remote Aboriginal communities where rheumatic fever is common and pyoderma is the predominant streptococcal infection. / McDonald, Malcolm; TOWERS, R; Fagan, Peter; Carapetis, Jonathan; Currie, Bart.

In: Epidemiology and Infection, Vol. 135, No. 8, 2007, p. 1398-1405.

Research output: Contribution to journal › Article › Research › peer-review

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AB - Aboriginal Australians in remote communities have high rates of rheumatic heart disease (RHD); yet pharyngitis is reportedly rare whilst pyoderma is common. Some strains of group A streptococci (GAS) have preference for the throat and others for the skin depending on M protein type. A study in three remote communities provided 350 GAS isolates for emm sequence typing, 244 were also emm pattern typed. There was 100% correlation between emm sequence and pattern type. Patterns D and E (non-throat tropic) made up 71% of throat and 87% of skin isolates although patterns A-C (throat tropic) were more common in the throat than the skin (RR 2.3, 95% CI 1.4 - 3.8) whilst the opposite was found for pattern D (RR 2.2, 95% CI 1.7 - 3.0). Pattern E favoured the throat (RR 1.4, 95% CI 1.1 - 1.8). Where environmental factors predispose to skin infection, emm pattern types D and E prevail, whatever the recovery site. � 2007 Cambridge University Press.

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KW - article

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KW - bacterium isolate

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KW - nonhuman

KW - pharyngitis

KW - pyoderma

KW - rheumatic fever

KW - rheumatic heart disease

KW - sequence analysis

KW - skin culture

KW - skin infection

KW - Streptococcus group A

KW - Streptococcus infection

KW - Streptococcus pyogenes

KW - throat culture

KW - child

KW - classification

KW - DNA sequence

KW - female

KW - genetics

KW - genotype

KW - isolation and purification

KW - male

KW - microbiology

KW - pharynx

KW - rural population

KW - skin

KW - Antigens, Bacterial

KW - Bacterial Outer Membrane Proteins

KW - Bacterial Typing Techniques

KW - Carrier Proteins

KW - Child

KW - DNA, Bacterial

KW - Female

KW - Genotype

KW - Humans

KW - Male

KW - Pharynx

KW - Pyoderma

KW - Rheumatic Fever

KW - Rural Population

KW - Sequence Analysis, DNA

KW - Skin

KW - Streptococcal Infections

M3 - Article

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JO - Epidemiology and Infection

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SN - 0950-2688

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McDonald M, TOWERS R, Fagan P, Carapetis J, Currie B. Molecular typing of Streptococcus pyogenes from remote Aboriginal communities where rheumatic fever is common and pyoderma is the predominant streptococcal infection. Epidemiology and Infection. 2007;135(8):1398-1405.