Abstract
Original language | English |
---|---|
Pages (from-to) | 1398-1405 |
Number of pages | 8 |
Journal | Epidemiology and Infection |
Volume | 135 |
Issue number | 8 |
Publication status | Published - 2007 |
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Molecular typing of Streptococcus pyogenes from remote Aboriginal communities where rheumatic fever is common and pyoderma is the predominant streptococcal infection. / McDonald, Malcolm; TOWERS, R; Fagan, Peter; Carapetis, Jonathan; Currie, Bart.
In: Epidemiology and Infection, Vol. 135, No. 8, 2007, p. 1398-1405.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Molecular typing of Streptococcus pyogenes from remote Aboriginal communities where rheumatic fever is common and pyoderma is the predominant streptococcal infection
AU - McDonald, Malcolm
AU - TOWERS, R
AU - Fagan, Peter
AU - Carapetis, Jonathan
AU - Currie, Bart
PY - 2007
Y1 - 2007
N2 - Aboriginal Australians in remote communities have high rates of rheumatic heart disease (RHD); yet pharyngitis is reportedly rare whilst pyoderma is common. Some strains of group A streptococci (GAS) have preference for the throat and others for the skin depending on M protein type. A study in three remote communities provided 350 GAS isolates for emm sequence typing, 244 were also emm pattern typed. There was 100% correlation between emm sequence and pattern type. Patterns D and E (non-throat tropic) made up 71% of throat and 87% of skin isolates although patterns A-C (throat tropic) were more common in the throat than the skin (RR 2.3, 95% CI 1.4 - 3.8) whilst the opposite was found for pattern D (RR 2.2, 95% CI 1.7 - 3.0). Pattern E favoured the throat (RR 1.4, 95% CI 1.1 - 1.8). Where environmental factors predispose to skin infection, emm pattern types D and E prevail, whatever the recovery site. � 2007 Cambridge University Press.
AB - Aboriginal Australians in remote communities have high rates of rheumatic heart disease (RHD); yet pharyngitis is reportedly rare whilst pyoderma is common. Some strains of group A streptococci (GAS) have preference for the throat and others for the skin depending on M protein type. A study in three remote communities provided 350 GAS isolates for emm sequence typing, 244 were also emm pattern typed. There was 100% correlation between emm sequence and pattern type. Patterns D and E (non-throat tropic) made up 71% of throat and 87% of skin isolates although patterns A-C (throat tropic) were more common in the throat than the skin (RR 2.3, 95% CI 1.4 - 3.8) whilst the opposite was found for pattern D (RR 2.2, 95% CI 1.7 - 3.0). Pattern E favoured the throat (RR 1.4, 95% CI 1.1 - 1.8). Where environmental factors predispose to skin infection, emm pattern types D and E prevail, whatever the recovery site. � 2007 Cambridge University Press.
KW - bacterial protein
KW - M protein
KW - protein emm
KW - unclassified drug
KW - bacterial antigen
KW - bacterial DNA
KW - carrier protein
KW - outer membrane protein
KW - streptococcal M protein
KW - Aborigine
KW - amino acid sequence
KW - article
KW - Australia
KW - bacterium identification
KW - bacterium isolate
KW - controlled study
KW - correlation analysis
KW - environmental factor
KW - human
KW - infection sensitivity
KW - major clinical study
KW - molecular typing
KW - nonhuman
KW - pharyngitis
KW - pyoderma
KW - rheumatic fever
KW - rheumatic heart disease
KW - sequence analysis
KW - skin culture
KW - skin infection
KW - Streptococcus group A
KW - Streptococcus infection
KW - Streptococcus pyogenes
KW - throat culture
KW - child
KW - classification
KW - DNA sequence
KW - female
KW - genetics
KW - genotype
KW - isolation and purification
KW - male
KW - microbiology
KW - pharynx
KW - rural population
KW - skin
KW - Antigens, Bacterial
KW - Bacterial Outer Membrane Proteins
KW - Bacterial Typing Techniques
KW - Carrier Proteins
KW - Child
KW - DNA, Bacterial
KW - Female
KW - Genotype
KW - Humans
KW - Male
KW - Pharynx
KW - Pyoderma
KW - Rheumatic Fever
KW - Rural Population
KW - Sequence Analysis, DNA
KW - Skin
KW - Streptococcal Infections
M3 - Article
VL - 135
SP - 1398
EP - 1405
JO - Epidemiology and Infection
JF - Epidemiology and Infection
SN - 0950-2688
IS - 8
ER -