@article{c440d085b49d461fb21dda6129cb1fa1,
title = "Molecular typing of Streptococcus pyogenes from remote Aboriginal communities where rheumatic fever is common and pyoderma is the predominant streptococcal infection",
abstract = "Aboriginal Australians in remote communities have high rates of rheumatic heart disease (RHD); yet pharyngitis is reportedly rare whilst pyoderma is common. Some strains of group A streptococci (GAS) have preference for the throat and others for the skin depending on M protein type. A study in three remote communities provided 350 GAS isolates for emm sequence typing, 244 were also emm pattern typed. There was 100% correlation between emm sequence and pattern type. Patterns D and E (non-throat tropic) made up 71% of throat and 87% of skin isolates although patterns A-C (throat tropic) were more common in the throat than the skin (RR 2.3, 95% CI 1.4 - 3.8) whilst the opposite was found for pattern D (RR 2.2, 95% CI 1.7 - 3.0). Pattern E favoured the throat (RR 1.4, 95% CI 1.1 - 1.8). Where environmental factors predispose to skin infection, emm pattern types D and E prevail, whatever the recovery site. � 2007 Cambridge University Press.",
keywords = "bacterial protein, M protein, protein emm, unclassified drug, bacterial antigen, bacterial DNA, carrier protein, outer membrane protein, streptococcal M protein, Aborigine, amino acid sequence, article, Australia, bacterium identification, bacterium isolate, controlled study, correlation analysis, environmental factor, human, infection sensitivity, major clinical study, molecular typing, nonhuman, pharyngitis, pyoderma, rheumatic fever, rheumatic heart disease, sequence analysis, skin culture, skin infection, Streptococcus group A, Streptococcus infection, Streptococcus pyogenes, throat culture, child, classification, DNA sequence, female, genetics, genotype, isolation and purification, male, microbiology, pharynx, rural population, skin, Antigens, Bacterial, Bacterial Outer Membrane Proteins, Bacterial Typing Techniques, Carrier Proteins, Child, DNA, Bacterial, Female, Genotype, Humans, Male, Pharynx, Pyoderma, Rheumatic Fever, Rural Population, Sequence Analysis, DNA, Skin, Streptococcal Infections",
author = "Malcolm McDonald and R TOWERS and Peter Fagan and Jonathan Carapetis and Bart Currie",
year = "2007",
language = "English",
volume = "135",
pages = "1398--1405",
journal = "Epidemiology and Infection",
issn = "0950-2688",
publisher = "Cambridge University Press",
number = "8",
}