Molecular typing of Streptococcus pyogenes from remote Aboriginal communities where rheumatic fever is common and pyoderma is the predominant streptococcal infection

Malcolm McDonald, R TOWERS, Peter Fagan, Jonathan Carapetis, Bart Currie

    Research output: Contribution to journalArticle

    Abstract

    Aboriginal Australians in remote communities have high rates of rheumatic heart disease (RHD); yet pharyngitis is reportedly rare whilst pyoderma is common. Some strains of group A streptococci (GAS) have preference for the throat and others for the skin depending on M protein type. A study in three remote communities provided 350 GAS isolates for emm sequence typing, 244 were also emm pattern typed. There was 100% correlation between emm sequence and pattern type. Patterns D and E (non-throat tropic) made up 71% of throat and 87% of skin isolates although patterns A-C (throat tropic) were more common in the throat than the skin (RR 2.3, 95% CI 1.4 - 3.8) whilst the opposite was found for pattern D (RR 2.2, 95% CI 1.7 - 3.0). Pattern E favoured the throat (RR 1.4, 95% CI 1.1 - 1.8). Where environmental factors predispose to skin infection, emm pattern types D and E prevail, whatever the recovery site. � 2007 Cambridge University Press.
    Original languageEnglish
    Pages (from-to)1398-1405
    Number of pages8
    JournalEpidemiology and Infection
    Volume135
    Issue number8
    Publication statusPublished - 2007

    Fingerprint Dive into the research topics of 'Molecular typing of Streptococcus pyogenes from remote Aboriginal communities where rheumatic fever is common and pyoderma is the predominant streptococcal infection'. Together they form a unique fingerprint.

  • Cite this