Monitoring antimalarial drug resistance: Applying lessons learned from the past in a fast-moving present

C Sibley, Ric Price

    Research output: Contribution to journalArticle

    Abstract

    The need for robust surveillance of antimalarial drugs is more urgent than it has ever been. In the western region of Cambodia, artemisinin resistance has emerged in Plasmodium falciparum and threatens to undermine the efficacy of highly effective artemisinin combination therapies. Although some manfestations of artemisinin tolerance are unique to this class of drug, many of its properties mirror previous experience in understanding and tracking resistance to other antimalarials. In this review we outline the spectrum of approaches that were developed to understand the evolution and spread of antifolate resistance, highlighting the importance of integrating information from different methodologies towards a better understanding of the underlying biologic processes. We consider how to apply our experience in investigating and attempting to contain antifolate resistance to inform our prospective assessment of novel antimalarial resistance patterns and their subsequent spread.
    Original languageEnglish
    Pages (from-to)126-133
    Number of pages8
    JournalInternational Journal for Parasitology
    Volume2
    DOIs
    Publication statusPublished - 2012

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