Monodispersed submicron porous silica particles functionalized with CD derivatives for chiral CEC

Lai Sheng Li, Yong Wang, David James Young, Siu Choon Ng, Timothy Thatt Yang Tan

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Rapid and efficient enantioseparation of halogen aryl alcohols and b-blockers propranolol and pindolol in packed bed CEC (p-CEC) using as-prepared submicron porous silica chiral stationary phases (CSPs) has been achieved. Monodispersed 0.66 and 0.81 mm chiral submicron porous silica spheres were prepared using tetramethoxysilane and hexadecyltrimethylammonium bromide, followed by a hydrothermal treatment method with ammonia-ethanol to expand the pore of silica spheres without changing their spherical morphology. A proper specific surface of ca. 230m2/g and pore sizes average of 6-8 nm were obtained by this method. The submicron porous silica spheres were modified with mono-6-phenylcarbamoylated β-CD via thiol-en radical addition. They were packed into 9 cm 50 mmid capillary columns with photopolymerized monolithic frits. These submicron CSPs showed greater column efficiency (about 476 000 plates/m for 4-iodophenyl-1-ethanol) and higher resolution than the corresponding 3 μm CSP.

Original languageEnglish
Pages (from-to)378-387
Number of pages10
JournalElectrophoresis
Volume31
Issue number2
DOIs
Publication statusPublished - Jan 2010
Externally publishedYes

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Silicon Dioxide
Derivatives
Ethanol
Pindolol
Halogens
Packed beds
Ammonia
Sulfhydryl Compounds
Propranolol
Pore size
Alcohols

Cite this

Li, Lai Sheng ; Wang, Yong ; Young, David James ; Ng, Siu Choon ; Tan, Timothy Thatt Yang. / Monodispersed submicron porous silica particles functionalized with CD derivatives for chiral CEC. In: Electrophoresis. 2010 ; Vol. 31, No. 2. pp. 378-387.
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abstract = "Rapid and efficient enantioseparation of halogen aryl alcohols and b-blockers propranolol and pindolol in packed bed CEC (p-CEC) using as-prepared submicron porous silica chiral stationary phases (CSPs) has been achieved. Monodispersed 0.66 and 0.81 mm chiral submicron porous silica spheres were prepared using tetramethoxysilane and hexadecyltrimethylammonium bromide, followed by a hydrothermal treatment method with ammonia-ethanol to expand the pore of silica spheres without changing their spherical morphology. A proper specific surface of ca. 230m2/g and pore sizes average of 6-8 nm were obtained by this method. The submicron porous silica spheres were modified with mono-6-phenylcarbamoylated β-CD via thiol-en radical addition. They were packed into 9 cm 50 mmid capillary columns with photopolymerized monolithic frits. These submicron CSPs showed greater column efficiency (about 476 000 plates/m for 4-iodophenyl-1-ethanol) and higher resolution than the corresponding 3 μm CSP.",
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Monodispersed submicron porous silica particles functionalized with CD derivatives for chiral CEC. / Li, Lai Sheng; Wang, Yong; Young, David James; Ng, Siu Choon; Tan, Timothy Thatt Yang.

In: Electrophoresis, Vol. 31, No. 2, 01.2010, p. 378-387.

Research output: Contribution to journalArticleResearchpeer-review

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