Muscle strength, mobility, quality of life and falls in patients on maintenance haemodialysis

A prospective study

Amanda Y. Wang, Catherine Sherrington, Tadashi Toyama, Martin P. Gallagher, Alan Cass, Yochiro Hirakawa, Qiang Li, Louisa Sukkar, Paul Snelling, Meg J. Jardine

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Aim: The aim is to explore (i) the relationship between quality of life and physical parameters (muscle strength and mobility) among people undergoing maintenance haemodialysis; (ii) changes in strength and mobility over time and predictors of changes; and (iii) whether strength and mobility were associated with falls.

    Methods: We recruited 51 maintenance haemodialysis patients to a prospective longitudinal study. Baseline quality of life was assessed using the SF-36 physical component summary and mental component summary scores. Muscle strength (ankle dorsiflexion strength measured with a hand-held dynamometer), mobility (short physical performance battery) and falls history were assessed at baseline, 12 and 36 months. Associations between variables at baseline were assessed with linear regression models. Changes in physical parameters were evaluated with paired t-tests and prediction of falls assessed by negative binominal regression.

    Results: Fifty and 34 patients completed 12 and 36 month follow-ups, respectively. Baseline mobility but not muscle strength correlated with physical component summary (P = 0.01 and P = 0.23, respectively). Neither baseline mobility nor muscle strength correlated with mental component summary. At 12 months, muscle strength and mobility had significantly deteriorated (mean ankle dorsiflexion strength 11.0 lb (SD 1.5) from 14.0 lb (SD 2.2), P < 0.01; short physical performance battery 8.5 (SD 2.8) from 9.3 (SD 2.6), P < 0.01). Falls at 12 and 36 months were predicted by baseline mobility (P = 0.06 and P = 0.02, respectively) but not muscle strength.

    Conclusion: Physical parameters appear to be associated with meaningful patient outcomes and showed measurable deterioration over relatively short time frames. Interventions, with the potential to slow physical decline in people receiving maintenance dialysis, such as exercise programmes, warrant further investigation.

    Original languageEnglish
    Pages (from-to)220-227
    Number of pages8
    JournalNephrology
    Volume22
    Issue number3
    DOIs
    Publication statusPublished - 1 Mar 2017

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    Muscle Strength
    Renal Dialysis
    Maintenance
    Quality of Life
    Prospective Studies
    Ankle
    Linear Models
    Longitudinal Studies
    Dialysis
    Hand
    History
    Exercise

    Cite this

    Wang, A. Y., Sherrington, C., Toyama, T., Gallagher, M. P., Cass, A., Hirakawa, Y., ... Jardine, M. J. (2017). Muscle strength, mobility, quality of life and falls in patients on maintenance haemodialysis: A prospective study. Nephrology, 22(3), 220-227. https://doi.org/10.1111/nep.12749
    Wang, Amanda Y. ; Sherrington, Catherine ; Toyama, Tadashi ; Gallagher, Martin P. ; Cass, Alan ; Hirakawa, Yochiro ; Li, Qiang ; Sukkar, Louisa ; Snelling, Paul ; Jardine, Meg J. / Muscle strength, mobility, quality of life and falls in patients on maintenance haemodialysis : A prospective study. In: Nephrology. 2017 ; Vol. 22, No. 3. pp. 220-227.
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    abstract = "Aim: The aim is to explore (i) the relationship between quality of life and physical parameters (muscle strength and mobility) among people undergoing maintenance haemodialysis; (ii) changes in strength and mobility over time and predictors of changes; and (iii) whether strength and mobility were associated with falls. Methods: We recruited 51 maintenance haemodialysis patients to a prospective longitudinal study. Baseline quality of life was assessed using the SF-36 physical component summary and mental component summary scores. Muscle strength (ankle dorsiflexion strength measured with a hand-held dynamometer), mobility (short physical performance battery) and falls history were assessed at baseline, 12 and 36 months. Associations between variables at baseline were assessed with linear regression models. Changes in physical parameters were evaluated with paired t-tests and prediction of falls assessed by negative binominal regression. Results: Fifty and 34 patients completed 12 and 36 month follow-ups, respectively. Baseline mobility but not muscle strength correlated with physical component summary (P = 0.01 and P = 0.23, respectively). Neither baseline mobility nor muscle strength correlated with mental component summary. At 12 months, muscle strength and mobility had significantly deteriorated (mean ankle dorsiflexion strength 11.0 lb (SD 1.5) from 14.0 lb (SD 2.2), P < 0.01; short physical performance battery 8.5 (SD 2.8) from 9.3 (SD 2.6), P < 0.01). Falls at 12 and 36 months were predicted by baseline mobility (P = 0.06 and P = 0.02, respectively) but not muscle strength. Conclusion: Physical parameters appear to be associated with meaningful patient outcomes and showed measurable deterioration over relatively short time frames. Interventions, with the potential to slow physical decline in people receiving maintenance dialysis, such as exercise programmes, warrant further investigation.",
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    Wang, AY, Sherrington, C, Toyama, T, Gallagher, MP, Cass, A, Hirakawa, Y, Li, Q, Sukkar, L, Snelling, P & Jardine, MJ 2017, 'Muscle strength, mobility, quality of life and falls in patients on maintenance haemodialysis: A prospective study', Nephrology, vol. 22, no. 3, pp. 220-227. https://doi.org/10.1111/nep.12749

    Muscle strength, mobility, quality of life and falls in patients on maintenance haemodialysis : A prospective study. / Wang, Amanda Y.; Sherrington, Catherine; Toyama, Tadashi; Gallagher, Martin P.; Cass, Alan; Hirakawa, Yochiro; Li, Qiang; Sukkar, Louisa; Snelling, Paul; Jardine, Meg J.

    In: Nephrology, Vol. 22, No. 3, 01.03.2017, p. 220-227.

    Research output: Contribution to journalArticleResearchpeer-review

    TY - JOUR

    T1 - Muscle strength, mobility, quality of life and falls in patients on maintenance haemodialysis

    T2 - A prospective study

    AU - Wang, Amanda Y.

    AU - Sherrington, Catherine

    AU - Toyama, Tadashi

    AU - Gallagher, Martin P.

    AU - Cass, Alan

    AU - Hirakawa, Yochiro

    AU - Li, Qiang

    AU - Sukkar, Louisa

    AU - Snelling, Paul

    AU - Jardine, Meg J.

    PY - 2017/3/1

    Y1 - 2017/3/1

    N2 - Aim: The aim is to explore (i) the relationship between quality of life and physical parameters (muscle strength and mobility) among people undergoing maintenance haemodialysis; (ii) changes in strength and mobility over time and predictors of changes; and (iii) whether strength and mobility were associated with falls. Methods: We recruited 51 maintenance haemodialysis patients to a prospective longitudinal study. Baseline quality of life was assessed using the SF-36 physical component summary and mental component summary scores. Muscle strength (ankle dorsiflexion strength measured with a hand-held dynamometer), mobility (short physical performance battery) and falls history were assessed at baseline, 12 and 36 months. Associations between variables at baseline were assessed with linear regression models. Changes in physical parameters were evaluated with paired t-tests and prediction of falls assessed by negative binominal regression. Results: Fifty and 34 patients completed 12 and 36 month follow-ups, respectively. Baseline mobility but not muscle strength correlated with physical component summary (P = 0.01 and P = 0.23, respectively). Neither baseline mobility nor muscle strength correlated with mental component summary. At 12 months, muscle strength and mobility had significantly deteriorated (mean ankle dorsiflexion strength 11.0 lb (SD 1.5) from 14.0 lb (SD 2.2), P < 0.01; short physical performance battery 8.5 (SD 2.8) from 9.3 (SD 2.6), P < 0.01). Falls at 12 and 36 months were predicted by baseline mobility (P = 0.06 and P = 0.02, respectively) but not muscle strength. Conclusion: Physical parameters appear to be associated with meaningful patient outcomes and showed measurable deterioration over relatively short time frames. Interventions, with the potential to slow physical decline in people receiving maintenance dialysis, such as exercise programmes, warrant further investigation.

    AB - Aim: The aim is to explore (i) the relationship between quality of life and physical parameters (muscle strength and mobility) among people undergoing maintenance haemodialysis; (ii) changes in strength and mobility over time and predictors of changes; and (iii) whether strength and mobility were associated with falls. Methods: We recruited 51 maintenance haemodialysis patients to a prospective longitudinal study. Baseline quality of life was assessed using the SF-36 physical component summary and mental component summary scores. Muscle strength (ankle dorsiflexion strength measured with a hand-held dynamometer), mobility (short physical performance battery) and falls history were assessed at baseline, 12 and 36 months. Associations between variables at baseline were assessed with linear regression models. Changes in physical parameters were evaluated with paired t-tests and prediction of falls assessed by negative binominal regression. Results: Fifty and 34 patients completed 12 and 36 month follow-ups, respectively. Baseline mobility but not muscle strength correlated with physical component summary (P = 0.01 and P = 0.23, respectively). Neither baseline mobility nor muscle strength correlated with mental component summary. At 12 months, muscle strength and mobility had significantly deteriorated (mean ankle dorsiflexion strength 11.0 lb (SD 1.5) from 14.0 lb (SD 2.2), P < 0.01; short physical performance battery 8.5 (SD 2.8) from 9.3 (SD 2.6), P < 0.01). Falls at 12 and 36 months were predicted by baseline mobility (P = 0.06 and P = 0.02, respectively) but not muscle strength. Conclusion: Physical parameters appear to be associated with meaningful patient outcomes and showed measurable deterioration over relatively short time frames. Interventions, with the potential to slow physical decline in people receiving maintenance dialysis, such as exercise programmes, warrant further investigation.

    KW - end-stage kidney disease

    KW - haemodialysis

    KW - quality of life

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    U2 - 10.1111/nep.12749

    DO - 10.1111/nep.12749

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