Nasopharyngeal microbial interactions in the era of pneumococcal conjugate vaccination

Eileen Dunne, Heidi Smith-Vaughan, Roy M Robins-Browne, Edward (Kim) MULHOLLAND, Catherine Satzke

    Research output: Contribution to journalArticle

    Abstract

    The nasopharynx of children is often colonised by microorganisms such as Streptococcus pneumoniae (the pneumococcus) that can cause infections including pneumonia and otitis media. In this complex environment, bacteria and viruses may impact each other through antagonistic as well as synergistic interactions. Vaccination may alter colonisation dynamics, evidenced by the rise in non-vaccine serotypes following pneumococcal conjugate vaccination. Discovery of an inverse relationship between S. pneumoniae and Staphylococcus aureus carriage generated concern that pneumococcal vaccination could increase S. aureus carriage and disease. Here we review data on co-colonisation of pathogens in the nasopharynx, focusing on S. pneumoniae and the impact of pneumococcal vaccination. Thus far, pneumococcal vaccination has not had a sustained impact on S. aureus carriage but it is associated with an increase in non-typeable Haemophilus influenzae in acute otitis media aetiology. Advances in bacterial and viral detection methodologies have facilitated research in nasopharyngeal microbiology and will aid investigation of potential vaccine-induced changes, particularly when baseline studies can be conducted prior to pneumococcal vaccine introduction.
    Original languageEnglish
    Pages (from-to)2333-2342
    Number of pages10
    JournalVaccine
    Volume31
    Issue number19
    DOIs
    Publication statusPublished - 1 May 2013

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