TY - JOUR
T1 - Notch Signalling
T2 - A Potential Therapeutic Pathway in Oral Squamous Cell Carcinoma
AU - Pandey, Ankit
AU - Bhuvanadas, Sreeshma
AU - Joseph, Joel P.
AU - Jayaraj, Rama
AU - Devi, Arikketh
PY - 2021/12
Y1 - 2021/12
N2 - Cancer, a set of diseases characterized by abnormal cell growth resulting from alteration in the expression pattern of diverse genes, is one of the prominent causes of mortality and morbidity worldwide. This modification of various genes leads to altered signalling cascades and changes in the molecular network. These changes eventually give rise to cellular dysfunction and then to systemic failure causing death. Of the several pathways that are aberrantly activated in cancer, Notch signalling pathway is a prominent one. Notch signalling pathway is a juxtracrine signalling pathway which activates the genes associated with cell proliferation, survival and angiogenesis. Notch signalling pathway components are seen to be upregulated in several types of cancer. Oral Squamous Cell Carcinoma (OSCC) is a predominant category of oral cancer where aberrant activation of Notch signalling causes tumour progression and metastasis. In this review, we discuss the Notch signalling pathway, its components, forms and its role in the progression and metastasis of oral squamous cell carcinoma.
AB - Cancer, a set of diseases characterized by abnormal cell growth resulting from alteration in the expression pattern of diverse genes, is one of the prominent causes of mortality and morbidity worldwide. This modification of various genes leads to altered signalling cascades and changes in the molecular network. These changes eventually give rise to cellular dysfunction and then to systemic failure causing death. Of the several pathways that are aberrantly activated in cancer, Notch signalling pathway is a prominent one. Notch signalling pathway is a juxtracrine signalling pathway which activates the genes associated with cell proliferation, survival and angiogenesis. Notch signalling pathway components are seen to be upregulated in several types of cancer. Oral Squamous Cell Carcinoma (OSCC) is a predominant category of oral cancer where aberrant activation of Notch signalling causes tumour progression and metastasis. In this review, we discuss the Notch signalling pathway, its components, forms and its role in the progression and metastasis of oral squamous cell carcinoma.
KW - Cancer
KW - Cellular dysfunction
KW - Metastasis
KW - Notch signalling pathway
KW - Oral squamous cell carcinoma
KW - Tumour progression
UR - http://www.scopus.com/inward/record.url?scp=85123646135&partnerID=8YFLogxK
U2 - 10.2174/1871530321666210421125231
DO - 10.2174/1871530321666210421125231
M3 - Review article
C2 - 33882814
AN - SCOPUS:85123646135
VL - 21
SP - 2159
EP - 2168
JO - Endocrine, Metabolic and Immune Disorders: Drug Targets
JF - Endocrine, Metabolic and Immune Disorders: Drug Targets
SN - 1871-5303
IS - 12
ER -