Occupational Exposure and Risk of Central Nervous System Demyelination

Patricia Valery, R Lucas, D WILLIAMS, M Pender, C CHAPMAN, A Coulthard, K Dear, T Dwyer, T Kilpatrick, A McMichael, I van der Mei, B Taylor, A Ponsonby

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    Abstract

    Inconsistent evidence exists regarding the association between work-related factors and risk of multiple sclerosis (MS). We examined the association between occupational exposures and risk of a first clinical diagnosis of central nervous system demyelination (FCD), which is strongly associated with progression to MS, in a matched case-control study of 276 FCD cases and 538 controls conducted in Australia (2003-2006). Using a personal residence and work calendar, information on occupational history and exposure to chemicals and animals was collected through face-to-face interviews. Few case-control differences were noted. Fewer cases had worked as professionals (?6 years) than controls (adjusted odds ratio (AOR) = 0.60, 95% confidence interval (CI): 0.37, 0.96). After further adjustment for number of children, cases were more likely to have ever been exposed to livestock than controls (AOR = 1.54, 95% CI: 1.03, 2.29). Among women, there was an increase in FCD risk associated with 10 or more years of exposure to livestock (AOR = 2.78, 95% CI: 1.22, 6.33) or 6 or more years of farming (AOR = 2.00, 95% CI: 1.23, 3.25; also adjusted for number of children). Similar findings were not evident among men. Thus, farming and exposure to livestock may be important factors in the development of FCD among women, with this finding further revealed after the confounding effect of parity or number of children is considered.
    Original languageEnglish
    Pages (from-to)954-961
    Number of pages8
    JournalAmerican Journal of Epidemiology
    Volume177
    Issue number9
    DOIs
    Publication statusPublished - 2013

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    Valery, P., Lucas, R., WILLIAMS, D., Pender, M., CHAPMAN, C., Coulthard, A., Dear, K., Dwyer, T., Kilpatrick, T., McMichael, A., van der Mei, I., Taylor, B., & Ponsonby, A. (2013). Occupational Exposure and Risk of Central Nervous System Demyelination. American Journal of Epidemiology, 177(9), 954-961. https://doi.org/10.1093/aje/kws361