Of rats and men: A translational model to understand vancomycin pharmacokinetic/toxicodynamic relationships

Marc H. Scheetz, Gwendolyn M. Pais, Thomas P. Lodise, Steven Y.C. Tong, Joshua S. Davis, J. Nicholas O'Donnell, Jiajun Liu, Michael Neely, Walter C. Prozialeck, Peter C. Lamar, Nathaniel J. Rhodes, Thomas Holland, Sean N. Avedissian

Research output: Contribution to journalArticlepeer-review

Abstract

Vancomycin area under the concentration curve (AUC) is known to predict vancomycin-induced acute kidney injury (AKI). Data were analyzed from a rat model (n = 48) and two prospective clinical studies (PROVIDE [n = 263] and CAMERA2 [n = 291]). A logit-link model was used to calculate the multiplicative factors between the probability of AKI from clinical studies and in the rat. The rat was 2.7 to 4.2 times more sensitive to AKI between AUCs of 199.5 and 794.3 mg․h/liter, respectively.

Original languageEnglish
Article numbere01060-21
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume65
Issue number10
DOIs
Publication statusPublished - Sep 2021

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