One-pot synthesis of some N-benzotriazol-1-ylmethyl-1,2,3,4- tetrahydroisoquinolines using benzotriazole-auxiliary

Cornelia Locher, Naseem H. Peerzada

    Research output: Contribution to journalComment/debate

    Abstract

    N-Benzotriazol-1-ylmethyl-1,2,3,4-tetrahydroisoquinolines are prepared at room temperature from the reaction between 1 hydroxymethylbenzotriazole (1), a 2-phenylethylamine (2a-e) and AlCl3. This one-pot Friedel-Crafts reaction is a convenient improvement of the previously reported two-step procedure. The replacement of the benzotriazolyl moiety has often been demonstrated before; hence, the products of this reaction can be used as versatile, stable precursors for the preparation of various N-substituted 1,2,3,4-tetrahydroisoquinolines.
    Original languageEnglish
    Pages (from-to)12-16
    Number of pages5
    JournalArkivoc
    Volume2000
    Issue numberPart (i): General papers
    Publication statusPublished - 2000

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