TY - JOUR
T1 - One-pot synthesis of some N-benzotriazol-1-ylmethyl-1,2,3,4- tetrahydroisoquinolines using benzotriazole-auxiliary
AU - Locher, Cornelia
AU - Peerzada, Naseem H.
PY - 2000
Y1 - 2000
N2 - N-Benzotriazol-1-ylmethyl-1,2,3,4-tetrahydroisoquinolines are prepared at room temperature from the reaction between 1 hydroxymethylbenzotriazole (1), a 2-phenylethylamine (2a-e) and AlCl3. This one-pot Friedel-Crafts reaction is a convenient improvement of the previously reported two-step procedure. The replacement of the benzotriazolyl moiety has often been demonstrated before; hence, the products of this reaction can be used as versatile, stable precursors for the preparation of various N-substituted 1,2,3,4-tetrahydroisoquinolines.
AB - N-Benzotriazol-1-ylmethyl-1,2,3,4-tetrahydroisoquinolines are prepared at room temperature from the reaction between 1 hydroxymethylbenzotriazole (1), a 2-phenylethylamine (2a-e) and AlCl3. This one-pot Friedel-Crafts reaction is a convenient improvement of the previously reported two-step procedure. The replacement of the benzotriazolyl moiety has often been demonstrated before; hence, the products of this reaction can be used as versatile, stable precursors for the preparation of various N-substituted 1,2,3,4-tetrahydroisoquinolines.
KW - One pot synthesis
KW - Benzotiralzole
KW - Friedel-Crafts reaction
UR - http://www.arkat-usa.org/get-file/19008/
UR - https://creativecommons.org/licenses/by/3.0/au
M3 - Comment/debate
VL - 2000
SP - 12
EP - 16
JO - Arkivoc
JF - Arkivoc
SN - 1551-7004
IS - Part (i): General papers
ER -