@article{de65d6ec4c8c419384f0d38ffc69d011,
title = "Opsonophagocytic activity following a reduced dose 7-valent pneumococcal conjugate vaccine infant primary series and 23-valent pneumococcal polysaccharide vaccine at 12 months of age",
abstract = "Opsonophagocytic activity (OPA) was measured following reduced infant doses of 7-valent pneumococcal conjugate vaccine (PCV-7) with or without 23-valent pneumococcal polysaccharide vaccine (PPV-23) at 12 months, and subsequent re-exposure to a small dose of pneumococcal polysaccharide antigens (mPPS) at 17 months. Fijian infants were randomized to receive 0, 1, 2, or 3 PCV-7 doses. Half received PPV-23 at 12 months and all received mPPS at 17 months. OPA was performed on up to 14 serotypes. Three and 2 PCV-7 doses resulted in similar OPA for most PCV-7 serotypes up to 9 months and for half of the serotypes at 12 months. A single dose improved OPA compared with the unvaccinated group. PPV-23 significantly improved OPA for all serotypes tested but in general, was associated with diminished responses following re-challenge. ",
keywords = "diphtheria pertussis tetanus hepatitis B vaccine, measles rubella vaccine, Pneumococcus vaccine, poliomyelitis vaccine, article, child, drug activity, drug safety, human, immunogenicity, infant, major clinical study, open study, opsonophagocytic activity, phagocytosis, phase 2 clinical trial, priority journal, randomized controlled trial, serotype, single blind procedure, vaccination, Antibodies, Bacterial, Fiji, Humans, Infant, Opsonin Proteins, Phagocytosis, Pneumococcal Vaccines",
author = "Fiona Russell and Jonathan Carapetis and Burton and J Lin and Paul Licciardi and Anne Balloch and Lisi Tikoduadua and Lepani Waqatakirewa and Yin Cheung and Mimi Tang and Nahm, {Moon H} and MULHOLLAND, {Edward (Kim)}",
year = "2011",
doi = "10.1016/j.vaccine.2010.10.046",
language = "English",
volume = "29",
pages = "535--544",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier",
number = "3",
}