Overlapping Streptococcus pyogenes and Streptococcus dysgalactiae subspecies equisimilis household transmission and mobile genetic element exchange

Ouli Xie; Cameron Zachreson; Gerry Tonkin-Hill; David J. Price; Jake A. Lacey; Jacqueline M. Morris; Malcolm I. McDonald; Asha C. Bowen; Philip M. Giffard; Bart J. Currie; Jonathan R. Carapetis; Deborah C. Holt; Stephen D.  Bentley; Mark R. Davies; Steven Y. C. Tong

doi:10.1038/s41467-024-47816-1

Overlapping Streptococcus pyogenes and Streptococcus dysgalactiae subspecies equisimilis household transmission and mobile genetic element exchange

Ouli Xie, Cameron Zachreson, Gerry Tonkin-Hill, David J. Price, Jake A. Lacey, Jacqueline M. Morris, Malcolm I. McDonald, Asha C. Bowen, Philip M. Giffard, Bart J. Currie, Jonathan R. Carapetis, Deborah C. Holt, Stephen D. Bentley, Mark R. Davies, Steven Y. C. Tong

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

78 Downloads (Pure)

Abstract

Streptococcus dysgalactiae subspecies equisimilis (SDSE) and Streptococcus pyogenes share skin and throat niches with extensive genomic homology and horizontal gene transfer (HGT) possibly underlying shared disease phenotypes. It is unknown if cross-species transmission interaction occurs. Here, we conduct a genomic analysis of a longitudinal household survey in remote Australian First Nations communities for patterns of cross-species transmission interaction and HGT. Collected from 4547 person-consultations, we analyse 294 SDSE and 315 S. pyogenes genomes. We find SDSE and S. pyogenes transmission intersects extensively among households and show that patterns of co-occurrence and transmission links are consistent with independent transmission without inter-species interference. We identify at least one of three near-identical cross-species mobile genetic elements (MGEs) carrying antimicrobial resistance or streptodornase virulence genes in 55 (19%) SDSE and 23 (7%) S. pyogenes isolates. These findings demonstrate co-circulation of both pathogens and HGT in communities with a high burden of streptococcal disease, supporting a need to integrate SDSE and S. pyogenes surveillance and control efforts.

Original language	English
Article number	3477
Pages (from-to)	1-12
Number of pages	12
Journal	Nature Communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-024-47816-1
Publication status	Published - Dec 2024

Bibliographical note

Publisher Copyright:
© The Author(s) 2024.

Access to Document

10.1038/s41467-024-47816-1

109231083-oaFinal published version, 1.96 MBLicence: CC BY

Cite this

Xie, O., Zachreson, C., Tonkin-Hill, G., Price, D. J., Lacey, J. A., Morris, J. M., McDonald, M. I., Bowen, A. C., Giffard, P. M., Currie, B. J., Carapetis, J. R., Holt, D. C., Bentley, S. D., Davies, M. R., & Tong, S. Y. C. (2024). Overlapping Streptococcus pyogenes and Streptococcus dysgalactiae subspecies equisimilis household transmission and mobile genetic element exchange. Nature Communications, 15(1), 1-12. Article 3477. https://doi.org/10.1038/s41467-024-47816-1

@article{4af315846fe84465830d470417af63cd,

title = "Overlapping Streptococcus pyogenes and Streptococcus dysgalactiae subspecies equisimilis household transmission and mobile genetic element exchange",

abstract = "Streptococcus dysgalactiae subspecies equisimilis (SDSE) and Streptococcus pyogenes share skin and throat niches with extensive genomic homology and horizontal gene transfer (HGT) possibly underlying shared disease phenotypes. It is unknown if cross-species transmission interaction occurs. Here, we conduct a genomic analysis of a longitudinal household survey in remote Australian First Nations communities for patterns of cross-species transmission interaction and HGT. Collected from 4547 person-consultations, we analyse 294 SDSE and 315 S. pyogenes genomes. We find SDSE and S. pyogenes transmission intersects extensively among households and show that patterns of co-occurrence and transmission links are consistent with independent transmission without inter-species interference. We identify at least one of three near-identical cross-species mobile genetic elements (MGEs) carrying antimicrobial resistance or streptodornase virulence genes in 55 (19%) SDSE and 23 (7%) S. pyogenes isolates. These findings demonstrate co-circulation of both pathogens and HGT in communities with a high burden of streptococcal disease, supporting a need to integrate SDSE and S. pyogenes surveillance and control efforts.",

author = "Ouli Xie and Cameron Zachreson and Gerry Tonkin-Hill and Price, {David J.} and Lacey, {Jake A.} and Morris, {Jacqueline M.} and McDonald, {Malcolm I.} and Bowen, {Asha C.} and Giffard, {Philip M.} and Currie, {Bart J.} and Carapetis, {Jonathan R.} and Holt, {Deborah C.} and Bentley, {Stephen D.} and Davies, {Mark R.} and Tong, {Steven Y. C.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = dec,

doi = "10.1038/s41467-024-47816-1",

language = "English",

volume = "15",

pages = "1--12",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

number = "1",

}

Xie, O, Zachreson, C, Tonkin-Hill, G, Price, DJ, Lacey, JA, Morris, JM, McDonald, MI, Bowen, AC, Giffard, PM , Currie, BJ, Carapetis, JR, Holt, DC, Bentley, SD, Davies, MR & Tong, SYC 2024, 'Overlapping Streptococcus pyogenes and Streptococcus dysgalactiae subspecies equisimilis household transmission and mobile genetic element exchange', Nature Communications, vol. 15, no. 1, 3477, pp. 1-12. https://doi.org/10.1038/s41467-024-47816-1

TY - JOUR

T1 - Overlapping Streptococcus pyogenes and Streptococcus dysgalactiae subspecies equisimilis household transmission and mobile genetic element exchange

AU - Xie, Ouli

AU - Zachreson, Cameron

AU - Tonkin-Hill, Gerry

AU - Price, David J.

AU - Lacey, Jake A.

AU - Morris, Jacqueline M.

AU - McDonald, Malcolm I.

AU - Bowen, Asha C.

AU - Giffard, Philip M.

AU - Currie, Bart J.

AU - Carapetis, Jonathan R.

AU - Holt, Deborah C.

AU - Bentley, Stephen D.

AU - Davies, Mark R.

AU - Tong, Steven Y. C.

PY - 2024/12

Y1 - 2024/12

N2 - Streptococcus dysgalactiae subspecies equisimilis (SDSE) and Streptococcus pyogenes share skin and throat niches with extensive genomic homology and horizontal gene transfer (HGT) possibly underlying shared disease phenotypes. It is unknown if cross-species transmission interaction occurs. Here, we conduct a genomic analysis of a longitudinal household survey in remote Australian First Nations communities for patterns of cross-species transmission interaction and HGT. Collected from 4547 person-consultations, we analyse 294 SDSE and 315 S. pyogenes genomes. We find SDSE and S. pyogenes transmission intersects extensively among households and show that patterns of co-occurrence and transmission links are consistent with independent transmission without inter-species interference. We identify at least one of three near-identical cross-species mobile genetic elements (MGEs) carrying antimicrobial resistance or streptodornase virulence genes in 55 (19%) SDSE and 23 (7%) S. pyogenes isolates. These findings demonstrate co-circulation of both pathogens and HGT in communities with a high burden of streptococcal disease, supporting a need to integrate SDSE and S. pyogenes surveillance and control efforts.

AB - Streptococcus dysgalactiae subspecies equisimilis (SDSE) and Streptococcus pyogenes share skin and throat niches with extensive genomic homology and horizontal gene transfer (HGT) possibly underlying shared disease phenotypes. It is unknown if cross-species transmission interaction occurs. Here, we conduct a genomic analysis of a longitudinal household survey in remote Australian First Nations communities for patterns of cross-species transmission interaction and HGT. Collected from 4547 person-consultations, we analyse 294 SDSE and 315 S. pyogenes genomes. We find SDSE and S. pyogenes transmission intersects extensively among households and show that patterns of co-occurrence and transmission links are consistent with independent transmission without inter-species interference. We identify at least one of three near-identical cross-species mobile genetic elements (MGEs) carrying antimicrobial resistance or streptodornase virulence genes in 55 (19%) SDSE and 23 (7%) S. pyogenes isolates. These findings demonstrate co-circulation of both pathogens and HGT in communities with a high burden of streptococcal disease, supporting a need to integrate SDSE and S. pyogenes surveillance and control efforts.

UR - http://www.scopus.com/inward/record.url?scp=85191235724&partnerID=8YFLogxK

U2 - 10.1038/s41467-024-47816-1

DO - 10.1038/s41467-024-47816-1

M3 - Article

SN - 2041-1723

VL - 15

SP - 1

EP - 12

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 3477

ER -

Overlapping Streptococcus pyogenes and Streptococcus dysgalactiae subspecies equisimilis household transmission and mobile genetic element exchange

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this