Oxygen transfer during aerobic exercise in a varanid lizard Varanus mertensi is limited by the circulation

P.B. Frappell, T Schultz, Keith Christian

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    Abstract

    Oxygen transfer during sustained maximal exercise while locomoting on a treadmill at 0.33 m s-1 was examined in a varanid lizard Varanus mertensi at 35 °C. The rate of oxygen consumption (O2) increased with locomotion from 3.49±0.75 (mean ± S.D.) to 14.0±4.0 ml O2 kg-1 min-1. Ventilation (E) increased, aided by increases in both tidal volume and frequency, in direct proportion to O2. The air convection requirement (E/O2=27) was therefore maintained, together with arterial PaCO2 and PaO2. The alveolar—arterial PO2 difference (PAO2—PaO2) also remained unchanged during exercise from its value at rest, which was approximately 20 mmHg. Pulmonary diffusion for carbon monoxide (0.116±0.027 ml kg-1min-1 mmHg-1) was double the value previously reported in V. exanthematicus and remained unchanged with exercise. Furthermore, exercise was associated with an increase in the arterial—venous O2 content difference (CaO2—CvO2), which was assisted by a marked Bohr shift in the hemoglobin saturation curve and further unloading of venous O2. During exercise the increase in cardiac output (tot) did not match the increase in O2, such that the blood convection requirement (tot/O2) decreased from the pre-exercise value of approximately 35 to 16 during exercise. Together, the results suggest that ventilation and O2 transfer across the lung are adequate to meet the aerobic needs of V. mertensi during exercise, but the decrease in the blood convection requirement in the presence of a large arterial—venous O2 content difference suggests that a limit in the transport of O2 is imposed by the circulation.
    Original languageEnglish
    Pages (from-to)2725-2736
    Number of pages12
    JournalJournal of Experimental Biology
    Volume205
    Issue number17
    Publication statusPublished - 2002

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    Varanus
    Convection
    Lizards
    lizard
    ventilation
    Ventilation
    lizards
    exercise
    convection
    Exercise
    Oxygen
    oxygen
    blood
    Lung
    Tidal Volume
    locomotion
    hemoglobin
    Carbon Monoxide
    Locomotion
    unloading

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    title = "Oxygen transfer during aerobic exercise in a varanid lizard Varanus mertensi is limited by the circulation",
    abstract = "Oxygen transfer during sustained maximal exercise while locomoting on a treadmill at 0.33 m s-1 was examined in a varanid lizard Varanus mertensi at 35 °C. The rate of oxygen consumption (V̇O2) increased with locomotion from 3.49±0.75 (mean ± S.D.) to 14.0±4.0 ml O2 kg-1 min-1. Ventilation (V̇E) increased, aided by increases in both tidal volume and frequency, in direct proportion to V̇O2. The air convection requirement (V̇E/V̇O2=27) was therefore maintained, together with arterial PaCO2 and PaO2. The alveolar—arterial PO2 difference (PAO2—PaO2) also remained unchanged during exercise from its value at rest, which was approximately 20 mmHg. Pulmonary diffusion for carbon monoxide (0.116±0.027 ml kg-1min-1 mmHg-1) was double the value previously reported in V. exanthematicus and remained unchanged with exercise. Furthermore, exercise was associated with an increase in the arterial—venous O2 content difference (CaO2—CvO2), which was assisted by a marked Bohr shift in the hemoglobin saturation curve and further unloading of venous O2. During exercise the increase in cardiac output (Q̇tot) did not match the increase in V̇O2, such that the blood convection requirement (Q̇tot/V̇O2) decreased from the pre-exercise value of approximately 35 to 16 during exercise. Together, the results suggest that ventilation and O2 transfer across the lung are adequate to meet the aerobic needs of V. mertensi during exercise, but the decrease in the blood convection requirement in the presence of a large arterial—venous O2 content difference suggests that a limit in the transport of O2 is imposed by the circulation.",
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    Oxygen transfer during aerobic exercise in a varanid lizard Varanus mertensi is limited by the circulation. / Frappell, P.B.; Schultz, T; Christian, Keith.

    In: Journal of Experimental Biology, Vol. 205, No. 17, 2002, p. 2725-2736.

    Research output: Contribution to journalArticleResearchpeer-review

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    T1 - Oxygen transfer during aerobic exercise in a varanid lizard Varanus mertensi is limited by the circulation

    AU - Frappell, P.B.

    AU - Schultz, T

    AU - Christian, Keith

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    N2 - Oxygen transfer during sustained maximal exercise while locomoting on a treadmill at 0.33 m s-1 was examined in a varanid lizard Varanus mertensi at 35 °C. The rate of oxygen consumption (V̇O2) increased with locomotion from 3.49±0.75 (mean ± S.D.) to 14.0±4.0 ml O2 kg-1 min-1. Ventilation (V̇E) increased, aided by increases in both tidal volume and frequency, in direct proportion to V̇O2. The air convection requirement (V̇E/V̇O2=27) was therefore maintained, together with arterial PaCO2 and PaO2. The alveolar—arterial PO2 difference (PAO2—PaO2) also remained unchanged during exercise from its value at rest, which was approximately 20 mmHg. Pulmonary diffusion for carbon monoxide (0.116±0.027 ml kg-1min-1 mmHg-1) was double the value previously reported in V. exanthematicus and remained unchanged with exercise. Furthermore, exercise was associated with an increase in the arterial—venous O2 content difference (CaO2—CvO2), which was assisted by a marked Bohr shift in the hemoglobin saturation curve and further unloading of venous O2. During exercise the increase in cardiac output (Q̇tot) did not match the increase in V̇O2, such that the blood convection requirement (Q̇tot/V̇O2) decreased from the pre-exercise value of approximately 35 to 16 during exercise. Together, the results suggest that ventilation and O2 transfer across the lung are adequate to meet the aerobic needs of V. mertensi during exercise, but the decrease in the blood convection requirement in the presence of a large arterial—venous O2 content difference suggests that a limit in the transport of O2 is imposed by the circulation.

    AB - Oxygen transfer during sustained maximal exercise while locomoting on a treadmill at 0.33 m s-1 was examined in a varanid lizard Varanus mertensi at 35 °C. The rate of oxygen consumption (V̇O2) increased with locomotion from 3.49±0.75 (mean ± S.D.) to 14.0±4.0 ml O2 kg-1 min-1. Ventilation (V̇E) increased, aided by increases in both tidal volume and frequency, in direct proportion to V̇O2. The air convection requirement (V̇E/V̇O2=27) was therefore maintained, together with arterial PaCO2 and PaO2. The alveolar—arterial PO2 difference (PAO2—PaO2) also remained unchanged during exercise from its value at rest, which was approximately 20 mmHg. Pulmonary diffusion for carbon monoxide (0.116±0.027 ml kg-1min-1 mmHg-1) was double the value previously reported in V. exanthematicus and remained unchanged with exercise. Furthermore, exercise was associated with an increase in the arterial—venous O2 content difference (CaO2—CvO2), which was assisted by a marked Bohr shift in the hemoglobin saturation curve and further unloading of venous O2. During exercise the increase in cardiac output (Q̇tot) did not match the increase in V̇O2, such that the blood convection requirement (Q̇tot/V̇O2) decreased from the pre-exercise value of approximately 35 to 16 during exercise. Together, the results suggest that ventilation and O2 transfer across the lung are adequate to meet the aerobic needs of V. mertensi during exercise, but the decrease in the blood convection requirement in the presence of a large arterial—venous O2 content difference suggests that a limit in the transport of O2 is imposed by the circulation.

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