Perinatal Risk Factors Associated with Gastroenteritis Hospitalizations in Aboriginal and Non-Aboriginal Children in Western Australia (2000-2012)

A Record Linkage Cohort Study

Parveen Fathima, Thomas Laurence Snelling, Nicholas de Klerk, Deborah Lehmann, Christopher Charles Blyth, Claire Shelley Waddington, Hannah Catherine Moore

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Background: Gastroenteritis is a leading cause of childhood morbidity worldwide. We aimed to assess the maternal and infant characteristics and population attributable fractions (PAFs) associated with childhood gastroenteritis-related hospitalizations.

    Methods: We conducted a whole-of-population retrospective birth cohort study of 367,476 children live-born in Western Australia (WA) 2000-2012. We identified hospital admissions up to age <15 years pertaining to these children, with a principal diagnosis code for infectious gastroenteritis. Cox regression was used to obtain the adjusted hazard ratios with 95% confidence intervals (CIs) and the PAFs associated with each risk factor in Aboriginal and non-Aboriginal children for their first gastroenteritis hospital admission.

    Results: There were a total of 15,888 gastroenteritis-related hospital admissions (25.7% occurring among Aboriginal children). The overall gastroenteritis hospitalization rate for children aged <15 years was 4.6/1000 child-years for non-Aboriginal children and 21.5/1000 child-years for Aboriginal children. Male gender, maternal age <20 years, pre-term birth, low birth weight, residence in remote regions of WA and birth in the pre-rotavirus vaccine era were significant independent risk factors for gastroenteritis hospitalization in both Aboriginal and non-Aboriginal children. Additionally, birth by caesarean section and low socio-economic status were identified as being associated with gastroenteritis hospitalization in non-Aboriginal children. PAFs suggest that 39% of all gastroenteritis hospitalizations in non-Aboriginal children (38% in Aboriginal children) could be averted if all children receive the rotavirus vaccine.

    Conclusion: Given the beneficial effect of infant rotavirus vaccination in preventing all-cause gastroenteritis hospitalization, efforts should be taken to optimize rotavirus vaccine coverage in those at highest risk.
    Original languageEnglish
    Pages (from-to)169-175
    Number of pages7
    JournalThe Pediatric Infectious Disease Journal
    Volume38
    Issue number2
    Early online date31 Mar 2018
    DOIs
    Publication statusPublished - 1 Feb 2019

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    Western Australia
    Gastroenteritis
    Hospitalization
    Cohort Studies
    Rotavirus Vaccines
    Parturition
    Term Birth
    Population
    Rotavirus
    Maternal Age
    Low Birth Weight Infant
    Population Characteristics
    Cesarean Section

    Cite this

    Fathima, Parveen ; Snelling, Thomas Laurence ; de Klerk, Nicholas ; Lehmann, Deborah ; Blyth, Christopher Charles ; Waddington, Claire Shelley ; Moore, Hannah Catherine. / Perinatal Risk Factors Associated with Gastroenteritis Hospitalizations in Aboriginal and Non-Aboriginal Children in Western Australia (2000-2012) : A Record Linkage Cohort Study. In: The Pediatric Infectious Disease Journal. 2019 ; Vol. 38, No. 2. pp. 169-175.
    @article{43b71d07070848b483d91ec511308499,
    title = "Perinatal Risk Factors Associated with Gastroenteritis Hospitalizations in Aboriginal and Non-Aboriginal Children in Western Australia (2000-2012): A Record Linkage Cohort Study",
    abstract = "Background: Gastroenteritis is a leading cause of childhood morbidity worldwide. We aimed to assess the maternal and infant characteristics and population attributable fractions (PAFs) associated with childhood gastroenteritis-related hospitalizations.Methods: We conducted a whole-of-population retrospective birth cohort study of 367,476 children live-born in Western Australia (WA) 2000-2012. We identified hospital admissions up to age <15 years pertaining to these children, with a principal diagnosis code for infectious gastroenteritis. Cox regression was used to obtain the adjusted hazard ratios with 95{\%} confidence intervals (CIs) and the PAFs associated with each risk factor in Aboriginal and non-Aboriginal children for their first gastroenteritis hospital admission.Results: There were a total of 15,888 gastroenteritis-related hospital admissions (25.7{\%} occurring among Aboriginal children). The overall gastroenteritis hospitalization rate for children aged <15 years was 4.6/1000 child-years for non-Aboriginal children and 21.5/1000 child-years for Aboriginal children. Male gender, maternal age <20 years, pre-term birth, low birth weight, residence in remote regions of WA and birth in the pre-rotavirus vaccine era were significant independent risk factors for gastroenteritis hospitalization in both Aboriginal and non-Aboriginal children. Additionally, birth by caesarean section and low socio-economic status were identified as being associated with gastroenteritis hospitalization in non-Aboriginal children. PAFs suggest that 39{\%} of all gastroenteritis hospitalizations in non-Aboriginal children (38{\%} in Aboriginal children) could be averted if all children receive the rotavirus vaccine.Conclusion: Given the beneficial effect of infant rotavirus vaccination in preventing all-cause gastroenteritis hospitalization, efforts should be taken to optimize rotavirus vaccine coverage in those at highest risk.",
    author = "Parveen Fathima and Snelling, {Thomas Laurence} and {de Klerk}, Nicholas and Deborah Lehmann and Blyth, {Christopher Charles} and Waddington, {Claire Shelley} and Moore, {Hannah Catherine}",
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    Perinatal Risk Factors Associated with Gastroenteritis Hospitalizations in Aboriginal and Non-Aboriginal Children in Western Australia (2000-2012) : A Record Linkage Cohort Study. / Fathima, Parveen; Snelling, Thomas Laurence; de Klerk, Nicholas; Lehmann, Deborah; Blyth, Christopher Charles; Waddington, Claire Shelley; Moore, Hannah Catherine.

    In: The Pediatric Infectious Disease Journal, Vol. 38, No. 2, 01.02.2019, p. 169-175.

    Research output: Contribution to journalArticleResearchpeer-review

    TY - JOUR

    T1 - Perinatal Risk Factors Associated with Gastroenteritis Hospitalizations in Aboriginal and Non-Aboriginal Children in Western Australia (2000-2012)

    T2 - A Record Linkage Cohort Study

    AU - Fathima, Parveen

    AU - Snelling, Thomas Laurence

    AU - de Klerk, Nicholas

    AU - Lehmann, Deborah

    AU - Blyth, Christopher Charles

    AU - Waddington, Claire Shelley

    AU - Moore, Hannah Catherine

    PY - 2019/2/1

    Y1 - 2019/2/1

    N2 - Background: Gastroenteritis is a leading cause of childhood morbidity worldwide. We aimed to assess the maternal and infant characteristics and population attributable fractions (PAFs) associated with childhood gastroenteritis-related hospitalizations.Methods: We conducted a whole-of-population retrospective birth cohort study of 367,476 children live-born in Western Australia (WA) 2000-2012. We identified hospital admissions up to age <15 years pertaining to these children, with a principal diagnosis code for infectious gastroenteritis. Cox regression was used to obtain the adjusted hazard ratios with 95% confidence intervals (CIs) and the PAFs associated with each risk factor in Aboriginal and non-Aboriginal children for their first gastroenteritis hospital admission.Results: There were a total of 15,888 gastroenteritis-related hospital admissions (25.7% occurring among Aboriginal children). The overall gastroenteritis hospitalization rate for children aged <15 years was 4.6/1000 child-years for non-Aboriginal children and 21.5/1000 child-years for Aboriginal children. Male gender, maternal age <20 years, pre-term birth, low birth weight, residence in remote regions of WA and birth in the pre-rotavirus vaccine era were significant independent risk factors for gastroenteritis hospitalization in both Aboriginal and non-Aboriginal children. Additionally, birth by caesarean section and low socio-economic status were identified as being associated with gastroenteritis hospitalization in non-Aboriginal children. PAFs suggest that 39% of all gastroenteritis hospitalizations in non-Aboriginal children (38% in Aboriginal children) could be averted if all children receive the rotavirus vaccine.Conclusion: Given the beneficial effect of infant rotavirus vaccination in preventing all-cause gastroenteritis hospitalization, efforts should be taken to optimize rotavirus vaccine coverage in those at highest risk.

    AB - Background: Gastroenteritis is a leading cause of childhood morbidity worldwide. We aimed to assess the maternal and infant characteristics and population attributable fractions (PAFs) associated with childhood gastroenteritis-related hospitalizations.Methods: We conducted a whole-of-population retrospective birth cohort study of 367,476 children live-born in Western Australia (WA) 2000-2012. We identified hospital admissions up to age <15 years pertaining to these children, with a principal diagnosis code for infectious gastroenteritis. Cox regression was used to obtain the adjusted hazard ratios with 95% confidence intervals (CIs) and the PAFs associated with each risk factor in Aboriginal and non-Aboriginal children for their first gastroenteritis hospital admission.Results: There were a total of 15,888 gastroenteritis-related hospital admissions (25.7% occurring among Aboriginal children). The overall gastroenteritis hospitalization rate for children aged <15 years was 4.6/1000 child-years for non-Aboriginal children and 21.5/1000 child-years for Aboriginal children. Male gender, maternal age <20 years, pre-term birth, low birth weight, residence in remote regions of WA and birth in the pre-rotavirus vaccine era were significant independent risk factors for gastroenteritis hospitalization in both Aboriginal and non-Aboriginal children. Additionally, birth by caesarean section and low socio-economic status were identified as being associated with gastroenteritis hospitalization in non-Aboriginal children. PAFs suggest that 39% of all gastroenteritis hospitalizations in non-Aboriginal children (38% in Aboriginal children) could be averted if all children receive the rotavirus vaccine.Conclusion: Given the beneficial effect of infant rotavirus vaccination in preventing all-cause gastroenteritis hospitalization, efforts should be taken to optimize rotavirus vaccine coverage in those at highest risk.

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    DO - 10.1097/INF.0000000000002063

    M3 - Article

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    EP - 175

    JO - Pediatric Infectious Disease Journal

    JF - Pediatric Infectious Disease Journal

    SN - 0891-3668

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    ER -