Abstract
Without using any additional ligands, RuCl3efficiently catalyses the reductive N-alkylation of aryl nitro compounds with alcohols using bio-based glycerol as the hydrogen source and without the need for any added solvents. The reaction can be easily manipulated to produce either imines or secondary amines in high yields. RuCl3-catalyzed reductive N-alkylation of nitroarenes with alcohols affords the corresponding imine products in good to excellent yields. Under the same reaction conditions, the one-pot sequential reaction of nitroarenes with alcohols and glycerol also gives amines in higher yields.
Original language | English |
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Pages (from-to) | 4169-4176 |
Number of pages | 8 |
Journal | Tetrahedron |
Volume | 72 |
Issue number | 29 |
DOIs | |
Publication status | Published - 21 Jul 2016 |
Externally published | Yes |