Phosphine ligand-free RuCl3-catalyzed reductive N-alkylation of aryl nitro compounds

Da Wei Tan, Hong Xi Li, David James Young, Jian Ping Lang

Research output: Contribution to journalArticle

Abstract

Without using any additional ligands, RuCl3efficiently catalyses the reductive N-alkylation of aryl nitro compounds with alcohols using bio-based glycerol as the hydrogen source and without the need for any added solvents. The reaction can be easily manipulated to produce either imines or secondary amines in high yields. RuCl3-catalyzed reductive N-alkylation of nitroarenes with alcohols affords the corresponding imine products in good to excellent yields. Under the same reaction conditions, the one-pot sequential reaction of nitroarenes with alcohols and glycerol also gives amines in higher yields.

Original languageEnglish
Pages (from-to)4169-4176
Number of pages8
JournalTetrahedron
Volume72
Issue number29
DOIs
Publication statusPublished - 21 Jul 2016
Externally publishedYes

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