Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity

Kasia Stepniewska, Ric Price, Colin Sutherland, Chris Drakeley, L Vonseidlein, F NOSTEN, N WHITE

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background. The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity. Methods. Retrospective data from Thailand, The Gambia and Tanzania were used. The data came from large prospective field-based clinical trials, which investigated gametocyte carriage after different anti-malarial drug treatments. Results. Gametocytaemia was detected during the observation period in 12% of patients (931 out of 7548) in Thailand, 34% (683 out of 2020) in The Gambia, and 31% (430 out of 1400) in Tanzania (p < 0.001). Approximately one third (33%, 680/2044) of the patients with gametocytaemia during the observation period, already had patent gametocytaemia at enrolment (day 0 or day 1): 35% (318/931) in Thailand, 37% (250/683) in The Gambia, 26% (112/430) in Tanzania. Maximum gametocytaemia was usually observed on or before the seventh day after starting treatment (93% in Thailand, 70% in Tanzania and 78% in The Gambia). Lowest gametocyte carriage rates were observed following treatment with artemisinin derivatives, while sulphadoxine- pyrimethamine (SP) was associated with significantly greater development of gametocytaemia than other drug treatments (p < 0.001). The duration of gametocyte carriage was shorter in Thailand by 86% and Tanzania by 65% than in The Gambia. Gametocyte carriage was 27% longer among people presenting with anaemia, and was shorter in duration among patients who received artemisinin derivatives, by 27% in Thailand and by 71% in Tanzania and The Gambia. Conclusion. This study confirms the independent association of gametocytaemia with anaemia, and the significantly lower prevalence and duration of gametocyte carriage following treatment with an artemisinin derivative. The large differences in gametocyte carriage rates between regions with different levels of malaria transmission suggest that drug interventions to prevent transmission will have different effects in different places. � 2008 Stepniewska et al; licensee BioMed Central Ltd.
Original languageEnglish
Pages (from-to)249-
JournalMalaria Journal
Volume7
Publication statusPublished - 2008

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Gambia
Tanzania
Thailand
Plasmodium falciparum
Malaria
Anemia
Observation
Pharmaceutical Preparations
Therapeutics
Antimalarials
Clinical Trials
artemisinine

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Stepniewska, K., Price, R., Sutherland, C., Drakeley, C., Vonseidlein, L., NOSTEN, F., & WHITE, N. (2008). Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity. Malaria Journal, 7, 249-.
Stepniewska, Kasia ; Price, Ric ; Sutherland, Colin ; Drakeley, Chris ; Vonseidlein, L ; NOSTEN, F ; WHITE, N. / Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity. In: Malaria Journal. 2008 ; Vol. 7. pp. 249-.
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abstract = "Background. The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity. Methods. Retrospective data from Thailand, The Gambia and Tanzania were used. The data came from large prospective field-based clinical trials, which investigated gametocyte carriage after different anti-malarial drug treatments. Results. Gametocytaemia was detected during the observation period in 12{\%} of patients (931 out of 7548) in Thailand, 34{\%} (683 out of 2020) in The Gambia, and 31{\%} (430 out of 1400) in Tanzania (p < 0.001). Approximately one third (33{\%}, 680/2044) of the patients with gametocytaemia during the observation period, already had patent gametocytaemia at enrolment (day 0 or day 1): 35{\%} (318/931) in Thailand, 37{\%} (250/683) in The Gambia, 26{\%} (112/430) in Tanzania. Maximum gametocytaemia was usually observed on or before the seventh day after starting treatment (93{\%} in Thailand, 70{\%} in Tanzania and 78{\%} in The Gambia). Lowest gametocyte carriage rates were observed following treatment with artemisinin derivatives, while sulphadoxine- pyrimethamine (SP) was associated with significantly greater development of gametocytaemia than other drug treatments (p < 0.001). The duration of gametocyte carriage was shorter in Thailand by 86{\%} and Tanzania by 65{\%} than in The Gambia. Gametocyte carriage was 27{\%} longer among people presenting with anaemia, and was shorter in duration among patients who received artemisinin derivatives, by 27{\%} in Thailand and by 71{\%} in Tanzania and The Gambia. Conclusion. This study confirms the independent association of gametocytaemia with anaemia, and the significantly lower prevalence and duration of gametocyte carriage following treatment with an artemisinin derivative. The large differences in gametocyte carriage rates between regions with different levels of malaria transmission suggest that drug interventions to prevent transmission will have different effects in different places. � 2008 Stepniewska et al; licensee BioMed Central Ltd.",
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Stepniewska, K, Price, R, Sutherland, C, Drakeley, C, Vonseidlein, L, NOSTEN, F & WHITE, N 2008, 'Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity', Malaria Journal, vol. 7, pp. 249-.

Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity. / Stepniewska, Kasia; Price, Ric; Sutherland, Colin; Drakeley, Chris; Vonseidlein, L; NOSTEN, F; WHITE, N.

In: Malaria Journal, Vol. 7, 2008, p. 249-.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity

AU - Stepniewska, Kasia

AU - Price, Ric

AU - Sutherland, Colin

AU - Drakeley, Chris

AU - Vonseidlein, L

AU - NOSTEN, F

AU - WHITE, N

PY - 2008

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N2 - Background. The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity. Methods. Retrospective data from Thailand, The Gambia and Tanzania were used. The data came from large prospective field-based clinical trials, which investigated gametocyte carriage after different anti-malarial drug treatments. Results. Gametocytaemia was detected during the observation period in 12% of patients (931 out of 7548) in Thailand, 34% (683 out of 2020) in The Gambia, and 31% (430 out of 1400) in Tanzania (p < 0.001). Approximately one third (33%, 680/2044) of the patients with gametocytaemia during the observation period, already had patent gametocytaemia at enrolment (day 0 or day 1): 35% (318/931) in Thailand, 37% (250/683) in The Gambia, 26% (112/430) in Tanzania. Maximum gametocytaemia was usually observed on or before the seventh day after starting treatment (93% in Thailand, 70% in Tanzania and 78% in The Gambia). Lowest gametocyte carriage rates were observed following treatment with artemisinin derivatives, while sulphadoxine- pyrimethamine (SP) was associated with significantly greater development of gametocytaemia than other drug treatments (p < 0.001). The duration of gametocyte carriage was shorter in Thailand by 86% and Tanzania by 65% than in The Gambia. Gametocyte carriage was 27% longer among people presenting with anaemia, and was shorter in duration among patients who received artemisinin derivatives, by 27% in Thailand and by 71% in Tanzania and The Gambia. Conclusion. This study confirms the independent association of gametocytaemia with anaemia, and the significantly lower prevalence and duration of gametocyte carriage following treatment with an artemisinin derivative. The large differences in gametocyte carriage rates between regions with different levels of malaria transmission suggest that drug interventions to prevent transmission will have different effects in different places. � 2008 Stepniewska et al; licensee BioMed Central Ltd.

AB - Background. The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity. Methods. Retrospective data from Thailand, The Gambia and Tanzania were used. The data came from large prospective field-based clinical trials, which investigated gametocyte carriage after different anti-malarial drug treatments. Results. Gametocytaemia was detected during the observation period in 12% of patients (931 out of 7548) in Thailand, 34% (683 out of 2020) in The Gambia, and 31% (430 out of 1400) in Tanzania (p < 0.001). Approximately one third (33%, 680/2044) of the patients with gametocytaemia during the observation period, already had patent gametocytaemia at enrolment (day 0 or day 1): 35% (318/931) in Thailand, 37% (250/683) in The Gambia, 26% (112/430) in Tanzania. Maximum gametocytaemia was usually observed on or before the seventh day after starting treatment (93% in Thailand, 70% in Tanzania and 78% in The Gambia). Lowest gametocyte carriage rates were observed following treatment with artemisinin derivatives, while sulphadoxine- pyrimethamine (SP) was associated with significantly greater development of gametocytaemia than other drug treatments (p < 0.001). The duration of gametocyte carriage was shorter in Thailand by 86% and Tanzania by 65% than in The Gambia. Gametocyte carriage was 27% longer among people presenting with anaemia, and was shorter in duration among patients who received artemisinin derivatives, by 27% in Thailand and by 71% in Tanzania and The Gambia. Conclusion. This study confirms the independent association of gametocytaemia with anaemia, and the significantly lower prevalence and duration of gametocyte carriage following treatment with an artemisinin derivative. The large differences in gametocyte carriage rates between regions with different levels of malaria transmission suggest that drug interventions to prevent transmission will have different effects in different places. � 2008 Stepniewska et al; licensee BioMed Central Ltd.

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KW - mefloquine

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Stepniewska K, Price R, Sutherland C, Drakeley C, Vonseidlein L, NOSTEN F et al. Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity. Malaria Journal. 2008;7:249-.