Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity

Kasia Stepniewska, Ric Price, Colin Sutherland, Chris Drakeley, L Vonseidlein, F NOSTEN, N WHITE

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Background. The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity. Methods. Retrospective data from Thailand, The Gambia and Tanzania were used. The data came from large prospective field-based clinical trials, which investigated gametocyte carriage after different anti-malarial drug treatments. Results. Gametocytaemia was detected during the observation period in 12% of patients (931 out of 7548) in Thailand, 34% (683 out of 2020) in The Gambia, and 31% (430 out of 1400) in Tanzania (p < 0.001). Approximately one third (33%, 680/2044) of the patients with gametocytaemia during the observation period, already had patent gametocytaemia at enrolment (day 0 or day 1): 35% (318/931) in Thailand, 37% (250/683) in The Gambia, 26% (112/430) in Tanzania. Maximum gametocytaemia was usually observed on or before the seventh day after starting treatment (93% in Thailand, 70% in Tanzania and 78% in The Gambia). Lowest gametocyte carriage rates were observed following treatment with artemisinin derivatives, while sulphadoxine- pyrimethamine (SP) was associated with significantly greater development of gametocytaemia than other drug treatments (p < 0.001). The duration of gametocyte carriage was shorter in Thailand by 86% and Tanzania by 65% than in The Gambia. Gametocyte carriage was 27% longer among people presenting with anaemia, and was shorter in duration among patients who received artemisinin derivatives, by 27% in Thailand and by 71% in Tanzania and The Gambia. Conclusion. This study confirms the independent association of gametocytaemia with anaemia, and the significantly lower prevalence and duration of gametocyte carriage following treatment with an artemisinin derivative. The large differences in gametocyte carriage rates between regions with different levels of malaria transmission suggest that drug interventions to prevent transmission will have different effects in different places. � 2008 Stepniewska et al; licensee BioMed Central Ltd.
    Original languageEnglish
    Pages (from-to)249-
    JournalMalaria Journal
    Volume7
    Publication statusPublished - 2008

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    Gambia
    Tanzania
    Thailand
    Plasmodium falciparum
    Malaria
    Anemia
    Observation
    Pharmaceutical Preparations
    Therapeutics
    Antimalarials
    Clinical Trials
    artemisinine

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    Stepniewska, K., Price, R., Sutherland, C., Drakeley, C., Vonseidlein, L., NOSTEN, F., & WHITE, N. (2008). Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity. Malaria Journal, 7, 249-.
    Stepniewska, Kasia ; Price, Ric ; Sutherland, Colin ; Drakeley, Chris ; Vonseidlein, L ; NOSTEN, F ; WHITE, N. / Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity. In: Malaria Journal. 2008 ; Vol. 7. pp. 249-.
    @article{00b4a36b6df148b9a3cceebcc27af5bd,
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    abstract = "Background. The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity. Methods. Retrospective data from Thailand, The Gambia and Tanzania were used. The data came from large prospective field-based clinical trials, which investigated gametocyte carriage after different anti-malarial drug treatments. Results. Gametocytaemia was detected during the observation period in 12{\%} of patients (931 out of 7548) in Thailand, 34{\%} (683 out of 2020) in The Gambia, and 31{\%} (430 out of 1400) in Tanzania (p < 0.001). Approximately one third (33{\%}, 680/2044) of the patients with gametocytaemia during the observation period, already had patent gametocytaemia at enrolment (day 0 or day 1): 35{\%} (318/931) in Thailand, 37{\%} (250/683) in The Gambia, 26{\%} (112/430) in Tanzania. Maximum gametocytaemia was usually observed on or before the seventh day after starting treatment (93{\%} in Thailand, 70{\%} in Tanzania and 78{\%} in The Gambia). Lowest gametocyte carriage rates were observed following treatment with artemisinin derivatives, while sulphadoxine- pyrimethamine (SP) was associated with significantly greater development of gametocytaemia than other drug treatments (p < 0.001). The duration of gametocyte carriage was shorter in Thailand by 86{\%} and Tanzania by 65{\%} than in The Gambia. Gametocyte carriage was 27{\%} longer among people presenting with anaemia, and was shorter in duration among patients who received artemisinin derivatives, by 27{\%} in Thailand and by 71{\%} in Tanzania and The Gambia. Conclusion. This study confirms the independent association of gametocytaemia with anaemia, and the significantly lower prevalence and duration of gametocyte carriage following treatment with an artemisinin derivative. The large differences in gametocyte carriage rates between regions with different levels of malaria transmission suggest that drug interventions to prevent transmission will have different effects in different places. � 2008 Stepniewska et al; licensee BioMed Central Ltd.",
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    author = "Kasia Stepniewska and Ric Price and Colin Sutherland and Chris Drakeley and L Vonseidlein and F NOSTEN and N WHITE",
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    Stepniewska, K, Price, R, Sutherland, C, Drakeley, C, Vonseidlein, L, NOSTEN, F & WHITE, N 2008, 'Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity', Malaria Journal, vol. 7, pp. 249-.

    Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity. / Stepniewska, Kasia; Price, Ric; Sutherland, Colin; Drakeley, Chris; Vonseidlein, L; NOSTEN, F; WHITE, N.

    In: Malaria Journal, Vol. 7, 2008, p. 249-.

    Research output: Contribution to journalArticleResearchpeer-review

    TY - JOUR

    T1 - Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity

    AU - Stepniewska, Kasia

    AU - Price, Ric

    AU - Sutherland, Colin

    AU - Drakeley, Chris

    AU - Vonseidlein, L

    AU - NOSTEN, F

    AU - WHITE, N

    PY - 2008

    Y1 - 2008

    N2 - Background. The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity. Methods. Retrospective data from Thailand, The Gambia and Tanzania were used. The data came from large prospective field-based clinical trials, which investigated gametocyte carriage after different anti-malarial drug treatments. Results. Gametocytaemia was detected during the observation period in 12% of patients (931 out of 7548) in Thailand, 34% (683 out of 2020) in The Gambia, and 31% (430 out of 1400) in Tanzania (p < 0.001). Approximately one third (33%, 680/2044) of the patients with gametocytaemia during the observation period, already had patent gametocytaemia at enrolment (day 0 or day 1): 35% (318/931) in Thailand, 37% (250/683) in The Gambia, 26% (112/430) in Tanzania. Maximum gametocytaemia was usually observed on or before the seventh day after starting treatment (93% in Thailand, 70% in Tanzania and 78% in The Gambia). Lowest gametocyte carriage rates were observed following treatment with artemisinin derivatives, while sulphadoxine- pyrimethamine (SP) was associated with significantly greater development of gametocytaemia than other drug treatments (p < 0.001). The duration of gametocyte carriage was shorter in Thailand by 86% and Tanzania by 65% than in The Gambia. Gametocyte carriage was 27% longer among people presenting with anaemia, and was shorter in duration among patients who received artemisinin derivatives, by 27% in Thailand and by 71% in Tanzania and The Gambia. Conclusion. This study confirms the independent association of gametocytaemia with anaemia, and the significantly lower prevalence and duration of gametocyte carriage following treatment with an artemisinin derivative. The large differences in gametocyte carriage rates between regions with different levels of malaria transmission suggest that drug interventions to prevent transmission will have different effects in different places. � 2008 Stepniewska et al; licensee BioMed Central Ltd.

    AB - Background. The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity. Methods. Retrospective data from Thailand, The Gambia and Tanzania were used. The data came from large prospective field-based clinical trials, which investigated gametocyte carriage after different anti-malarial drug treatments. Results. Gametocytaemia was detected during the observation period in 12% of patients (931 out of 7548) in Thailand, 34% (683 out of 2020) in The Gambia, and 31% (430 out of 1400) in Tanzania (p < 0.001). Approximately one third (33%, 680/2044) of the patients with gametocytaemia during the observation period, already had patent gametocytaemia at enrolment (day 0 or day 1): 35% (318/931) in Thailand, 37% (250/683) in The Gambia, 26% (112/430) in Tanzania. Maximum gametocytaemia was usually observed on or before the seventh day after starting treatment (93% in Thailand, 70% in Tanzania and 78% in The Gambia). Lowest gametocyte carriage rates were observed following treatment with artemisinin derivatives, while sulphadoxine- pyrimethamine (SP) was associated with significantly greater development of gametocytaemia than other drug treatments (p < 0.001). The duration of gametocyte carriage was shorter in Thailand by 86% and Tanzania by 65% than in The Gambia. Gametocyte carriage was 27% longer among people presenting with anaemia, and was shorter in duration among patients who received artemisinin derivatives, by 27% in Thailand and by 71% in Tanzania and The Gambia. Conclusion. This study confirms the independent association of gametocytaemia with anaemia, and the significantly lower prevalence and duration of gametocyte carriage following treatment with an artemisinin derivative. The large differences in gametocyte carriage rates between regions with different levels of malaria transmission suggest that drug interventions to prevent transmission will have different effects in different places. � 2008 Stepniewska et al; licensee BioMed Central Ltd.

    KW - antipyretic agent

    KW - artemisinin

    KW - chloroquine

    KW - fansidar

    KW - halofantrine

    KW - mefloquine

    KW - quinine

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    KW - artemisinin derivative

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    KW - sulfadoxine

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    KW - anemia

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    KW - controlled study

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    KW - female

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    KW - gametocyte

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    KW - infant

    KW - major clinical study

    KW - malaria

    KW - male

    KW - Plasmodium falciparum

    KW - Tanzania

    KW - Thailand

    KW - animal

    KW - comparative study

    KW - drug combination

    KW - drug effect

    KW - growth, development and aging

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    KW - multivariate analysis

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    KW - proportional hazards model

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    KW - Adolescent

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    KW - Antimalarials

    KW - Artemisinins

    KW - Carrier State

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    KW - Child, Preschool

    KW - Drug Combinations

    KW - Endemic Diseases

    KW - Female

    KW - Humans

    KW - Infant

    KW - Infant, Newborn

    KW - Kaplan-Meiers Estimate

    KW - Malaria, Falciparum

    KW - Male

    KW - Multivariate Analysis

    KW - Parasitemia

    KW - Proportional Hazards Models

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    KW - Retrospective Studies

    KW - Sulfadoxine

    M3 - Article

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    SP - 249-

    JO - Malaria Journal

    JF - Malaria Journal

    SN - 1475-2875

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    Stepniewska K, Price R, Sutherland C, Drakeley C, Vonseidlein L, NOSTEN F et al. Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity. Malaria Journal. 2008;7:249-.