Plasmodium knowlesi Malaria During Pregnancy

Bridget Barber, Elspeth Bird, Christopher Wilkes, Timothy Williams, Matthew Grigg, Uma Paramaswaran, Jayaram Menon, Jenarun Jelip, Tsin Yeo, Nicholas Anstey

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Background: Plasmodium knowlesi is the commonest cause of malaria in Malaysia, but little is known regarding infection during pregnancy.

    Methods: To investigate comparative risk and consequences of knowlesi malaria during pregnancy, we reviewed (1) Sabah Health Department malaria-notification records created during 2012-2013, (2) prospectively collected data from all females with polymerase chain reaction (PCR)-confirmed malaria who were admitted to a Sabah tertiary care referral hospital during 2011-2014, and (3) malaria microscopy and clinical data recorded at a Sabah tertiary care women and children's hospital during 2010-2014.

    Results: During 2012-2013, 774 females with microscopy-diagnosed malaria were notified, including 252 (33%), 172 (20%), 333 (43%), and 17 (2%) with Plasmodium falciparum infection, Plasmodium vivax infection, Plasmodium malariae/Plasmodium knowlesi infection, and mixed infection, respectively. Among females aged 15-45 years, pregnancy was reported in 18 of 124 (14.5%), 9 of 93 (9.7%), and 4 of 151 (2.6%) P. falciparum, P. vivax, and P. malariae/P. knowlesi notifications respectively (P =.002). Three females with knowlesi malaria were confirmed as pregnant: 2 had moderate anemia, and 1 delivered a preterm low-birth-weight infant. There were 17, 7, and 0 pregnant women with falciparum, vivax, and knowlesi malaria, respectively, identified from the 2 referral hospitals.

    Conclusions: Although P. knowlesi is the commonest malaria species among females in Sabah, P. knowlesi infection is relatively rare during pregnancy. It may however be associated with adverse maternal and pregnancy outcomes.
    Original languageEnglish
    Pages (from-to)1104-1110
    Number of pages7
    JournalJournal of Infectious Diseases
    Volume211
    Issue number7
    Early online date10 Nov 2014
    DOIs
    Publication statusPublished - 2015

    Fingerprint

    Plasmodium knowlesi
    Plasmodium malariae
    Malaria
    Pregnancy
    Malaysia
    Vivax Malaria
    Tertiary Healthcare
    Plasmodium falciparum
    Microscopy
    Plasmodium vivax
    Plasmodium
    Premature Birth
    Low Birth Weight Infant
    Pregnancy Outcome
    Coinfection
    Tertiary Care Centers
    Premature Infants

    Cite this

    Barber, Bridget ; Bird, Elspeth ; Wilkes, Christopher ; Williams, Timothy ; Grigg, Matthew ; Paramaswaran, Uma ; Menon, Jayaram ; Jelip, Jenarun ; Yeo, Tsin ; Anstey, Nicholas. / Plasmodium knowlesi Malaria During Pregnancy. In: Journal of Infectious Diseases. 2015 ; Vol. 211, No. 7. pp. 1104-1110.
    @article{134f456033ad448a8c647e3ea9ad57b6,
    title = "Plasmodium knowlesi Malaria During Pregnancy",
    abstract = "Background: Plasmodium knowlesi is the commonest cause of malaria in Malaysia, but little is known regarding infection during pregnancy. Methods: To investigate comparative risk and consequences of knowlesi malaria during pregnancy, we reviewed (1) Sabah Health Department malaria-notification records created during 2012-2013, (2) prospectively collected data from all females with polymerase chain reaction (PCR)-confirmed malaria who were admitted to a Sabah tertiary care referral hospital during 2011-2014, and (3) malaria microscopy and clinical data recorded at a Sabah tertiary care women and children's hospital during 2010-2014. Results: During 2012-2013, 774 females with microscopy-diagnosed malaria were notified, including 252 (33{\%}), 172 (20{\%}), 333 (43{\%}), and 17 (2{\%}) with Plasmodium falciparum infection, Plasmodium vivax infection, Plasmodium malariae/Plasmodium knowlesi infection, and mixed infection, respectively. Among females aged 15-45 years, pregnancy was reported in 18 of 124 (14.5{\%}), 9 of 93 (9.7{\%}), and 4 of 151 (2.6{\%}) P. falciparum, P. vivax, and P. malariae/P. knowlesi notifications respectively (P =.002). Three females with knowlesi malaria were confirmed as pregnant: 2 had moderate anemia, and 1 delivered a preterm low-birth-weight infant. There were 17, 7, and 0 pregnant women with falciparum, vivax, and knowlesi malaria, respectively, identified from the 2 referral hospitals. Conclusions: Although P. knowlesi is the commonest malaria species among females in Sabah, P. knowlesi infection is relatively rare during pregnancy. It may however be associated with adverse maternal and pregnancy outcomes.",
    keywords = "adolescent, adult, anemia, child, Conference Paper, disease severity, female, human, incidence, low birth weight, major clinical study, malaria falciparum, Malaysia, mixed infection, Plasmodium knowlesi malaria, Plasmodium malariae infection, Plasmodium vivax malaria, pregnancy, prematurity, priority journal, prospective study, risk assessment, trend study, genetics, geography, infection control, isolation and purification, malaria, middle aged, parasitology, Plasmodium knowlesi, polymerase chain reaction, Pregnancy Complications, Parasitic, tertiary care center, young adult, protozoal DNA, Adolescent, Adult, Anemia, Disease Notification, DNA, Protozoan, Female, Geography, Humans, Malaria, Middle Aged, Polymerase Chain Reaction, Pregnancy, Prospective Studies, Tertiary Care Centers, Young Adult",
    author = "Bridget Barber and Elspeth Bird and Christopher Wilkes and Timothy Williams and Matthew Grigg and Uma Paramaswaran and Jayaram Menon and Jenarun Jelip and Tsin Yeo and Nicholas Anstey",
    year = "2015",
    doi = "10.1093/infdis/jiu562",
    language = "English",
    volume = "211",
    pages = "1104--1110",
    journal = "Journal of Infectious Diseases",
    issn = "0022-1899",
    publisher = "Oxford University Press",
    number = "7",

    }

    Barber, B, Bird, E, Wilkes, C, Williams, T, Grigg, M, Paramaswaran, U, Menon, J, Jelip, J, Yeo, T & Anstey, N 2015, 'Plasmodium knowlesi Malaria During Pregnancy', Journal of Infectious Diseases, vol. 211, no. 7, pp. 1104-1110. https://doi.org/10.1093/infdis/jiu562

    Plasmodium knowlesi Malaria During Pregnancy. / Barber, Bridget; Bird, Elspeth; Wilkes, Christopher; Williams, Timothy; Grigg, Matthew; Paramaswaran, Uma; Menon, Jayaram; Jelip, Jenarun; Yeo, Tsin; Anstey, Nicholas.

    In: Journal of Infectious Diseases, Vol. 211, No. 7, 2015, p. 1104-1110.

    Research output: Contribution to journalArticleResearchpeer-review

    TY - JOUR

    T1 - Plasmodium knowlesi Malaria During Pregnancy

    AU - Barber, Bridget

    AU - Bird, Elspeth

    AU - Wilkes, Christopher

    AU - Williams, Timothy

    AU - Grigg, Matthew

    AU - Paramaswaran, Uma

    AU - Menon, Jayaram

    AU - Jelip, Jenarun

    AU - Yeo, Tsin

    AU - Anstey, Nicholas

    PY - 2015

    Y1 - 2015

    N2 - Background: Plasmodium knowlesi is the commonest cause of malaria in Malaysia, but little is known regarding infection during pregnancy. Methods: To investigate comparative risk and consequences of knowlesi malaria during pregnancy, we reviewed (1) Sabah Health Department malaria-notification records created during 2012-2013, (2) prospectively collected data from all females with polymerase chain reaction (PCR)-confirmed malaria who were admitted to a Sabah tertiary care referral hospital during 2011-2014, and (3) malaria microscopy and clinical data recorded at a Sabah tertiary care women and children's hospital during 2010-2014. Results: During 2012-2013, 774 females with microscopy-diagnosed malaria were notified, including 252 (33%), 172 (20%), 333 (43%), and 17 (2%) with Plasmodium falciparum infection, Plasmodium vivax infection, Plasmodium malariae/Plasmodium knowlesi infection, and mixed infection, respectively. Among females aged 15-45 years, pregnancy was reported in 18 of 124 (14.5%), 9 of 93 (9.7%), and 4 of 151 (2.6%) P. falciparum, P. vivax, and P. malariae/P. knowlesi notifications respectively (P =.002). Three females with knowlesi malaria were confirmed as pregnant: 2 had moderate anemia, and 1 delivered a preterm low-birth-weight infant. There were 17, 7, and 0 pregnant women with falciparum, vivax, and knowlesi malaria, respectively, identified from the 2 referral hospitals. Conclusions: Although P. knowlesi is the commonest malaria species among females in Sabah, P. knowlesi infection is relatively rare during pregnancy. It may however be associated with adverse maternal and pregnancy outcomes.

    AB - Background: Plasmodium knowlesi is the commonest cause of malaria in Malaysia, but little is known regarding infection during pregnancy. Methods: To investigate comparative risk and consequences of knowlesi malaria during pregnancy, we reviewed (1) Sabah Health Department malaria-notification records created during 2012-2013, (2) prospectively collected data from all females with polymerase chain reaction (PCR)-confirmed malaria who were admitted to a Sabah tertiary care referral hospital during 2011-2014, and (3) malaria microscopy and clinical data recorded at a Sabah tertiary care women and children's hospital during 2010-2014. Results: During 2012-2013, 774 females with microscopy-diagnosed malaria were notified, including 252 (33%), 172 (20%), 333 (43%), and 17 (2%) with Plasmodium falciparum infection, Plasmodium vivax infection, Plasmodium malariae/Plasmodium knowlesi infection, and mixed infection, respectively. Among females aged 15-45 years, pregnancy was reported in 18 of 124 (14.5%), 9 of 93 (9.7%), and 4 of 151 (2.6%) P. falciparum, P. vivax, and P. malariae/P. knowlesi notifications respectively (P =.002). Three females with knowlesi malaria were confirmed as pregnant: 2 had moderate anemia, and 1 delivered a preterm low-birth-weight infant. There were 17, 7, and 0 pregnant women with falciparum, vivax, and knowlesi malaria, respectively, identified from the 2 referral hospitals. Conclusions: Although P. knowlesi is the commonest malaria species among females in Sabah, P. knowlesi infection is relatively rare during pregnancy. It may however be associated with adverse maternal and pregnancy outcomes.

    KW - adolescent

    KW - adult

    KW - anemia

    KW - child

    KW - Conference Paper

    KW - disease severity

    KW - female

    KW - human

    KW - incidence

    KW - low birth weight

    KW - major clinical study

    KW - malaria falciparum

    KW - Malaysia

    KW - mixed infection

    KW - Plasmodium knowlesi malaria

    KW - Plasmodium malariae infection

    KW - Plasmodium vivax malaria

    KW - pregnancy

    KW - prematurity

    KW - priority journal

    KW - prospective study

    KW - risk assessment

    KW - trend study

    KW - genetics

    KW - geography

    KW - infection control

    KW - isolation and purification

    KW - malaria

    KW - middle aged

    KW - parasitology

    KW - Plasmodium knowlesi

    KW - polymerase chain reaction

    KW - Pregnancy Complications, Parasitic

    KW - tertiary care center

    KW - young adult

    KW - protozoal DNA

    KW - Adolescent

    KW - Adult

    KW - Anemia

    KW - Disease Notification

    KW - DNA, Protozoan

    KW - Female

    KW - Geography

    KW - Humans

    KW - Malaria

    KW - Middle Aged

    KW - Polymerase Chain Reaction

    KW - Pregnancy

    KW - Prospective Studies

    KW - Tertiary Care Centers

    KW - Young Adult

    UR - http://www.scopus.com/inward/record.url?scp=84927722382&partnerID=8YFLogxK

    U2 - 10.1093/infdis/jiu562

    DO - 10.1093/infdis/jiu562

    M3 - Article

    VL - 211

    SP - 1104

    EP - 1110

    JO - Journal of Infectious Diseases

    JF - Journal of Infectious Diseases

    SN - 0022-1899

    IS - 7

    ER -