Plasmodium knowlesi Malaria During Pregnancy

Bridget Barber, Elspeth Bird, Christopher Wilkes, Timothy Williams, Matthew Grigg, Uma Paramaswaran, Jayaram Menon, Jenarun Jelip, Tsin Yeo, Nicholas Anstey

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Plasmodium knowlesi is the commonest cause of malaria in Malaysia, but little is known regarding infection during pregnancy.

Methods: To investigate comparative risk and consequences of knowlesi malaria during pregnancy, we reviewed (1) Sabah Health Department malaria-notification records created during 2012-2013, (2) prospectively collected data from all females with polymerase chain reaction (PCR)-confirmed malaria who were admitted to a Sabah tertiary care referral hospital during 2011-2014, and (3) malaria microscopy and clinical data recorded at a Sabah tertiary care women and children's hospital during 2010-2014.

Results: During 2012-2013, 774 females with microscopy-diagnosed malaria were notified, including 252 (33%), 172 (20%), 333 (43%), and 17 (2%) with Plasmodium falciparum infection, Plasmodium vivax infection, Plasmodium malariae/Plasmodium knowlesi infection, and mixed infection, respectively. Among females aged 15-45 years, pregnancy was reported in 18 of 124 (14.5%), 9 of 93 (9.7%), and 4 of 151 (2.6%) P. falciparum, P. vivax, and P. malariae/P. knowlesi notifications respectively (P =.002). Three females with knowlesi malaria were confirmed as pregnant: 2 had moderate anemia, and 1 delivered a preterm low-birth-weight infant. There were 17, 7, and 0 pregnant women with falciparum, vivax, and knowlesi malaria, respectively, identified from the 2 referral hospitals.

Conclusions: Although P. knowlesi is the commonest malaria species among females in Sabah, P. knowlesi infection is relatively rare during pregnancy. It may however be associated with adverse maternal and pregnancy outcomes.
Original languageEnglish
Pages (from-to)1104-1110
Number of pages7
JournalJournal of Infectious Diseases
Volume211
Issue number7
Early online date10 Nov 2014
DOIs
Publication statusPublished - 2015

Fingerprint

Plasmodium knowlesi
Plasmodium malariae
Malaria
Pregnancy
Malaysia
Vivax Malaria
Tertiary Healthcare
Plasmodium falciparum
Microscopy
Plasmodium vivax
Plasmodium
Premature Birth
Low Birth Weight Infant
Pregnancy Outcome
Coinfection
Tertiary Care Centers
Premature Infants

Cite this

Barber, Bridget ; Bird, Elspeth ; Wilkes, Christopher ; Williams, Timothy ; Grigg, Matthew ; Paramaswaran, Uma ; Menon, Jayaram ; Jelip, Jenarun ; Yeo, Tsin ; Anstey, Nicholas. / Plasmodium knowlesi Malaria During Pregnancy. In: Journal of Infectious Diseases. 2015 ; Vol. 211, No. 7. pp. 1104-1110.
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title = "Plasmodium knowlesi Malaria During Pregnancy",
abstract = "Background: Plasmodium knowlesi is the commonest cause of malaria in Malaysia, but little is known regarding infection during pregnancy. Methods: To investigate comparative risk and consequences of knowlesi malaria during pregnancy, we reviewed (1) Sabah Health Department malaria-notification records created during 2012-2013, (2) prospectively collected data from all females with polymerase chain reaction (PCR)-confirmed malaria who were admitted to a Sabah tertiary care referral hospital during 2011-2014, and (3) malaria microscopy and clinical data recorded at a Sabah tertiary care women and children's hospital during 2010-2014. Results: During 2012-2013, 774 females with microscopy-diagnosed malaria were notified, including 252 (33{\%}), 172 (20{\%}), 333 (43{\%}), and 17 (2{\%}) with Plasmodium falciparum infection, Plasmodium vivax infection, Plasmodium malariae/Plasmodium knowlesi infection, and mixed infection, respectively. Among females aged 15-45 years, pregnancy was reported in 18 of 124 (14.5{\%}), 9 of 93 (9.7{\%}), and 4 of 151 (2.6{\%}) P. falciparum, P. vivax, and P. malariae/P. knowlesi notifications respectively (P =.002). Three females with knowlesi malaria were confirmed as pregnant: 2 had moderate anemia, and 1 delivered a preterm low-birth-weight infant. There were 17, 7, and 0 pregnant women with falciparum, vivax, and knowlesi malaria, respectively, identified from the 2 referral hospitals. Conclusions: Although P. knowlesi is the commonest malaria species among females in Sabah, P. knowlesi infection is relatively rare during pregnancy. It may however be associated with adverse maternal and pregnancy outcomes.",
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Barber, B, Bird, E, Wilkes, C, Williams, T, Grigg, M, Paramaswaran, U, Menon, J, Jelip, J, Yeo, T & Anstey, N 2015, 'Plasmodium knowlesi Malaria During Pregnancy', Journal of Infectious Diseases, vol. 211, no. 7, pp. 1104-1110. https://doi.org/10.1093/infdis/jiu562

Plasmodium knowlesi Malaria During Pregnancy. / Barber, Bridget; Bird, Elspeth; Wilkes, Christopher; Williams, Timothy; Grigg, Matthew; Paramaswaran, Uma; Menon, Jayaram; Jelip, Jenarun; Yeo, Tsin; Anstey, Nicholas.

In: Journal of Infectious Diseases, Vol. 211, No. 7, 2015, p. 1104-1110.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Plasmodium knowlesi Malaria During Pregnancy

AU - Barber, Bridget

AU - Bird, Elspeth

AU - Wilkes, Christopher

AU - Williams, Timothy

AU - Grigg, Matthew

AU - Paramaswaran, Uma

AU - Menon, Jayaram

AU - Jelip, Jenarun

AU - Yeo, Tsin

AU - Anstey, Nicholas

PY - 2015

Y1 - 2015

N2 - Background: Plasmodium knowlesi is the commonest cause of malaria in Malaysia, but little is known regarding infection during pregnancy. Methods: To investigate comparative risk and consequences of knowlesi malaria during pregnancy, we reviewed (1) Sabah Health Department malaria-notification records created during 2012-2013, (2) prospectively collected data from all females with polymerase chain reaction (PCR)-confirmed malaria who were admitted to a Sabah tertiary care referral hospital during 2011-2014, and (3) malaria microscopy and clinical data recorded at a Sabah tertiary care women and children's hospital during 2010-2014. Results: During 2012-2013, 774 females with microscopy-diagnosed malaria were notified, including 252 (33%), 172 (20%), 333 (43%), and 17 (2%) with Plasmodium falciparum infection, Plasmodium vivax infection, Plasmodium malariae/Plasmodium knowlesi infection, and mixed infection, respectively. Among females aged 15-45 years, pregnancy was reported in 18 of 124 (14.5%), 9 of 93 (9.7%), and 4 of 151 (2.6%) P. falciparum, P. vivax, and P. malariae/P. knowlesi notifications respectively (P =.002). Three females with knowlesi malaria were confirmed as pregnant: 2 had moderate anemia, and 1 delivered a preterm low-birth-weight infant. There were 17, 7, and 0 pregnant women with falciparum, vivax, and knowlesi malaria, respectively, identified from the 2 referral hospitals. Conclusions: Although P. knowlesi is the commonest malaria species among females in Sabah, P. knowlesi infection is relatively rare during pregnancy. It may however be associated with adverse maternal and pregnancy outcomes.

AB - Background: Plasmodium knowlesi is the commonest cause of malaria in Malaysia, but little is known regarding infection during pregnancy. Methods: To investigate comparative risk and consequences of knowlesi malaria during pregnancy, we reviewed (1) Sabah Health Department malaria-notification records created during 2012-2013, (2) prospectively collected data from all females with polymerase chain reaction (PCR)-confirmed malaria who were admitted to a Sabah tertiary care referral hospital during 2011-2014, and (3) malaria microscopy and clinical data recorded at a Sabah tertiary care women and children's hospital during 2010-2014. Results: During 2012-2013, 774 females with microscopy-diagnosed malaria were notified, including 252 (33%), 172 (20%), 333 (43%), and 17 (2%) with Plasmodium falciparum infection, Plasmodium vivax infection, Plasmodium malariae/Plasmodium knowlesi infection, and mixed infection, respectively. Among females aged 15-45 years, pregnancy was reported in 18 of 124 (14.5%), 9 of 93 (9.7%), and 4 of 151 (2.6%) P. falciparum, P. vivax, and P. malariae/P. knowlesi notifications respectively (P =.002). Three females with knowlesi malaria were confirmed as pregnant: 2 had moderate anemia, and 1 delivered a preterm low-birth-weight infant. There were 17, 7, and 0 pregnant women with falciparum, vivax, and knowlesi malaria, respectively, identified from the 2 referral hospitals. Conclusions: Although P. knowlesi is the commonest malaria species among females in Sabah, P. knowlesi infection is relatively rare during pregnancy. It may however be associated with adverse maternal and pregnancy outcomes.

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