Abstract
| Original language | English |
|---|---|
| Article number | e82553 |
| Pages (from-to) | 1-10 |
| Number of pages | 10 |
| Journal | PLoS One |
| Volume | 8 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2013 |
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Plasmodium vivax Population Structure and Transmission Dynamics in Sabah Malaysia. / Abdullah, Noor; Barber, Bridget; William, Timothy; Norahmad, Nor; Satsu, Umi; Muniandy, Prem; Ismail, Zakiah; Grigg, Matthew; Jelip, Jenarun; Piera, Kim; Von Seidlein, Lorenz; Yeo, Tsin; Anstey, Nicholas; Price, Ric; Auburn, Sarah.
In: PLoS One, Vol. 8, No. 12, e82553, 2013, p. 1-10.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Plasmodium vivax Population Structure and Transmission Dynamics in Sabah Malaysia
AU - Abdullah, Noor
AU - Barber, Bridget
AU - William, Timothy
AU - Norahmad, Nor
AU - Satsu, Umi
AU - Muniandy, Prem
AU - Ismail, Zakiah
AU - Grigg, Matthew
AU - Jelip, Jenarun
AU - Piera, Kim
AU - Von Seidlein, Lorenz
AU - Yeo, Tsin
AU - Anstey, Nicholas
AU - Price, Ric
AU - Auburn, Sarah
PY - 2013
Y1 - 2013
N2 - Despite significant progress in the control of malaria in Malaysia, the complex transmission dynamics of P. vivax continue to challenge national efforts to achieve elimination. To assess the impact of ongoing interventions on P. vivax transmission dynamics in Sabah, we genotyped 9 short tandem repeat markers in a total of 97 isolates (8 recurrences) from across Sabah, with a focus on two districts, Kota Marudu (KM, n = 24) and Kota Kinabalu (KK, n = 21), over a 2 year period. STRUCTURE analysis on the Sabah-wide dataset demonstrated multiple sub-populations. Significant differentiation (FST = 0.243) was observed between KM and KK, located just 130 Km apart. Consistent with low endemic transmission, infection complexity was modest in both KM (mean MOI = 1.38) and KK (mean MOI = 1.19). However, population diversity remained moderate (HE = 0.583 in KM and HE = 0.667 in KK). Temporal trends revealed clonal expansions reflecting epidemic transmission dynamics. The haplotypes of these isolates declined in frequency over time, but persisted at low frequency throughout the study duration. A diverse array of low frequency isolates were detected in both KM and KK, some likely reflecting remnants of previous expansions. In accordance with clonal expansions, high levels of Linkage Disequilibrium (IA S >0.5 [P<0.0001] in KK and KM) declined sharply when identical haplotypes were represented once (I A S = 0.07 [P = 0.0076] in KM, and IA S = - 0.003 [P = 0.606] in KK). All 8 recurrences, likely to be relapses, were homologous to the prior infection. These recurrences may promote the persistence of parasite lineages, sustaining local diversity. In summary, Sabah's shrinking P. vivax population appears to have rendered this low endemic setting vulnerable to epidemic expansions. Migration may play an important role in the introduction of new parasite strains leading to epidemic expansions, with important implications for malaria elimination.
AB - Despite significant progress in the control of malaria in Malaysia, the complex transmission dynamics of P. vivax continue to challenge national efforts to achieve elimination. To assess the impact of ongoing interventions on P. vivax transmission dynamics in Sabah, we genotyped 9 short tandem repeat markers in a total of 97 isolates (8 recurrences) from across Sabah, with a focus on two districts, Kota Marudu (KM, n = 24) and Kota Kinabalu (KK, n = 21), over a 2 year period. STRUCTURE analysis on the Sabah-wide dataset demonstrated multiple sub-populations. Significant differentiation (FST = 0.243) was observed between KM and KK, located just 130 Km apart. Consistent with low endemic transmission, infection complexity was modest in both KM (mean MOI = 1.38) and KK (mean MOI = 1.19). However, population diversity remained moderate (HE = 0.583 in KM and HE = 0.667 in KK). Temporal trends revealed clonal expansions reflecting epidemic transmission dynamics. The haplotypes of these isolates declined in frequency over time, but persisted at low frequency throughout the study duration. A diverse array of low frequency isolates were detected in both KM and KK, some likely reflecting remnants of previous expansions. In accordance with clonal expansions, high levels of Linkage Disequilibrium (IA S >0.5 [P<0.0001] in KK and KM) declined sharply when identical haplotypes were represented once (I A S = 0.07 [P = 0.0076] in KM, and IA S = - 0.003 [P = 0.606] in KK). All 8 recurrences, likely to be relapses, were homologous to the prior infection. These recurrences may promote the persistence of parasite lineages, sustaining local diversity. In summary, Sabah's shrinking P. vivax population appears to have rendered this low endemic setting vulnerable to epidemic expansions. Migration may play an important role in the introduction of new parasite strains leading to epidemic expansions, with important implications for malaria elimination.
KW - adolescent
KW - adult
KW - aged
KW - article
KW - child
KW - endemic disease
KW - haplotype
KW - human
KW - major clinical study
KW - Malaysia
KW - microbial diversity
KW - nonhuman
KW - parasite isolation
KW - parasite migration
KW - parasite transmission
KW - Plasmodium vivax
KW - Plasmodium vivax malaria
KW - population differentiation
KW - population structure
KW - prevalence
KW - recurrent disease
KW - relapse
KW - short tandem repeat
KW - DNA, Protozoan
KW - Endemic Diseases
KW - Genetic Variation
KW - Genotype
KW - Humans
KW - Linkage Disequilibrium
KW - Malaria, Vivax
KW - Prevalence
KW - Recurrence
UR - http://www.scopus.com/inward/record.url?scp=84893086402&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0082553
DO - 10.1371/journal.pone.0082553
M3 - Article
VL - 8
SP - 1
EP - 10
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 12
M1 - e82553
ER -