Pneumococcal nasopharyngeal carriage following reduced doses of a 7-valent pneumococcal conjugate vaccine and a 23-valent pneumococcal polysaccharide vaccine booster

Fiona Russell, Jonathan Carapetis, Catherine Satzke, Lisi Tikoduadua, Lepani Waqatakirewa, Reginald Chandra, Anna Seduadua, Shahin Oftadeh, Yin Cheung, Gwendolyn Gilbert, Edward (Kim) MULHOLLAND

    Research output: Contribution to journalArticle

    Abstract

    This study was conducted to evaluate the effect of a reduced-dose 7-valent pneumococcal conjugate vaccine (PCV) primary series followed by a 23-valent pneumococcal polysaccharide vaccine (23vPPS) booster on nasopharyngeal (NP) pneumococcal carriage. For this purpose, Fijian infants aged 6 weeks were randomized to receive 0, 1, 2, or 3 PCV doses. Within each group, half received 23vPPS at 12 months. NP swabs were taken at 6, 9, 12, and 17 months and were cultured for Streptococcus pneumoniae. Isolates were serotyped by multiplex PCR and a reverse line blot assay. There were no significant differences in PCV vaccine type (VT) carriage between the 3- and 2-dose groups at 12 months. NP VT carriage was significantly higher (P, <0.01) in the unvaccinated group than in the 3-dose group at the age of 9 months. There appeared to be a PCV dose effect in the cumulative proportion of infants carrying the VT, with less VT carriage occurring with more doses of PCV. Non-PCV serotype (NVT) carriage rates were similar for all PCV groups. When groups were pooled by receipt or nonreceipt of 23vPPS at 12 months, there were no differences in pneumococcal, VT, or NVT carriage rates between the 2 groups at the age of 17 months. In conclusion, there appeared to be a PCV dose effect on VT carriage, with less VT carriage occurring with more doses of PCV. By the age of 17 months, NVT carriage rates were similar for all groups. 23vPPS had no impact on carriage, despite the substantial boosts in antibody levels. Copyright � 2010, American Society for Microbiology. All Rights Reserved.
    Original languageEnglish
    Pages (from-to)1970-1976
    Number of pages7
    JournalClinical and Vaccine Immunology
    Volume17
    Issue number12
    Publication statusPublished - 2010

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    Russell, F., Carapetis, J., Satzke, C., Tikoduadua, L., Waqatakirewa, L., Chandra, R., Seduadua, A., Oftadeh, S., Cheung, Y., Gilbert, G., & MULHOLLAND, E. K. (2010). Pneumococcal nasopharyngeal carriage following reduced doses of a 7-valent pneumococcal conjugate vaccine and a 23-valent pneumococcal polysaccharide vaccine booster. Clinical and Vaccine Immunology, 17(12), 1970-1976.