Polycystic ovary syndrome and Metabolic syndrome in Indigenous Australian women

Jacqueline Anne Boyle, Joan Cunningham, Robert Norman, Terry Dunbar, Kerin O'Dea

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Abstract

Background: Polycystic ovary syndrome (PCOS) affects around 15% of Indigenous women who are also a group at high risk of cardiometabolic disease.

Aim: To explore the impact of PCOS on metabolic syndrome in Indigenous women.

Methods: 
A cross-sectional reproductive health questionnaire, biochemical and anthropometric assessments, of 109 Indigenous women (35 with PCOS and 74 without PCOS) aged 15–44 years in and around Darwin between 2003 and 2005. PCOS was defined using the National Institutes of Health criteria, and metabolic syndrome (MetS) using the National Cholesterol Education Programme Adult Treatment Programme III criteria. The outcome was prevalence of MetS by PCOS status; relationship of PCOS with MetS before and after adjustment for markers of obesity and insulin resistance.

Results: 
Women with PCOS had a significantly higher body mass index (BMI) (P = 0.0001) and MetS was more frequent in women with PCOS (51%) than those without PCOS (23%) (P = 0.003). The most frequent components of MetS in both groups were a high density lipoprotein cholesterol ≤1.29 mmol/L (80% PCOS, 55% non-PCOS) and a waist circumference >88 cm (77% PCOS, 41% non-PCOS); these were significantly more frequent in women with PCOS (P = 0.01). In logistic regression models, PCOS was significantly associated with MetS by itself but not after adjustment for BMI or sex hormone binding globulin.

Conclusions: 
While MetS was more common in Indigenous women with PCOS, PCOS was not an independent predictor of MetS. This may be because obesity and insulin resistance are integral parts of PCOS and are the mechanisms through which PCOS exerts metabolic effects.
Original languageEnglish
Pages (from-to)1247-1254
Number of pages8
JournalInternal Medicine Journal
Volume45
Issue number12
DOIs
Publication statusPublished - Dec 2015

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Polycystic Ovary Syndrome
Insulin Resistance
Ovary
Body Mass Index
Obesity
Logistic Models
Sex Hormone-Binding Globulin
Reproductive Health
National Institutes of Health (U.S.)
Waist Circumference

Cite this

Boyle, Jacqueline Anne ; Cunningham, Joan ; Norman, Robert ; Dunbar, Terry ; O'Dea, Kerin. / Polycystic ovary syndrome and Metabolic syndrome in Indigenous Australian women. In: Internal Medicine Journal. 2015 ; Vol. 45, No. 12. pp. 1247-1254.
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title = "Polycystic ovary syndrome and Metabolic syndrome in Indigenous Australian women",
abstract = "Background: Polycystic ovary syndrome (PCOS) affects around 15{\%} of Indigenous women who are also a group at high risk of cardiometabolic disease.Aim: To explore the impact of PCOS on metabolic syndrome in Indigenous women.Methods: A cross-sectional reproductive health questionnaire, biochemical and anthropometric assessments, of 109 Indigenous women (35 with PCOS and 74 without PCOS) aged 15–44 years in and around Darwin between 2003 and 2005. PCOS was defined using the National Institutes of Health criteria, and metabolic syndrome (MetS) using the National Cholesterol Education Programme Adult Treatment Programme III criteria. The outcome was prevalence of MetS by PCOS status; relationship of PCOS with MetS before and after adjustment for markers of obesity and insulin resistance.Results: Women with PCOS had a significantly higher body mass index (BMI) (P = 0.0001) and MetS was more frequent in women with PCOS (51{\%}) than those without PCOS (23{\%}) (P = 0.003). The most frequent components of MetS in both groups were a high density lipoprotein cholesterol ≤1.29 mmol/L (80{\%} PCOS, 55{\%} non-PCOS) and a waist circumference >88 cm (77{\%} PCOS, 41{\%} non-PCOS); these were significantly more frequent in women with PCOS (P = 0.01). In logistic regression models, PCOS was significantly associated with MetS by itself but not after adjustment for BMI or sex hormone binding globulin.Conclusions: While MetS was more common in Indigenous women with PCOS, PCOS was not an independent predictor of MetS. This may be because obesity and insulin resistance are integral parts of PCOS and are the mechanisms through which PCOS exerts metabolic effects.",
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Polycystic ovary syndrome and Metabolic syndrome in Indigenous Australian women. / Boyle, Jacqueline Anne; Cunningham, Joan; Norman, Robert; Dunbar, Terry; O'Dea, Kerin.

In: Internal Medicine Journal, Vol. 45, No. 12, 12.2015, p. 1247-1254.

Research output: Contribution to journalArticleResearchpeer-review

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N2 - Background: Polycystic ovary syndrome (PCOS) affects around 15% of Indigenous women who are also a group at high risk of cardiometabolic disease.Aim: To explore the impact of PCOS on metabolic syndrome in Indigenous women.Methods: A cross-sectional reproductive health questionnaire, biochemical and anthropometric assessments, of 109 Indigenous women (35 with PCOS and 74 without PCOS) aged 15–44 years in and around Darwin between 2003 and 2005. PCOS was defined using the National Institutes of Health criteria, and metabolic syndrome (MetS) using the National Cholesterol Education Programme Adult Treatment Programme III criteria. The outcome was prevalence of MetS by PCOS status; relationship of PCOS with MetS before and after adjustment for markers of obesity and insulin resistance.Results: Women with PCOS had a significantly higher body mass index (BMI) (P = 0.0001) and MetS was more frequent in women with PCOS (51%) than those without PCOS (23%) (P = 0.003). The most frequent components of MetS in both groups were a high density lipoprotein cholesterol ≤1.29 mmol/L (80% PCOS, 55% non-PCOS) and a waist circumference >88 cm (77% PCOS, 41% non-PCOS); these were significantly more frequent in women with PCOS (P = 0.01). In logistic regression models, PCOS was significantly associated with MetS by itself but not after adjustment for BMI or sex hormone binding globulin.Conclusions: While MetS was more common in Indigenous women with PCOS, PCOS was not an independent predictor of MetS. This may be because obesity and insulin resistance are integral parts of PCOS and are the mechanisms through which PCOS exerts metabolic effects.

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