Population data provide evidence against the presence of a set point for hemoglobin levels or tissue oxygen delivery

Stephen P. Fitzgerald, Niels Grote Beverborg, Yves Beguin, Ferruh Artunc, Henrik Falhammar, Nigel G. Bean

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    Abstract

    Hemoglobin levels are believed to be regulated as per a set point model of regulation. This model of regulation, by which specific levels of a parameter are targeted and defended by physiological systems, implies a particular population correlation between the parameter and its controlling hormone. Empirical population correlations of other parameters and their controlling hormones, have denied the presence of such set point-based regulation. To assess if hemoglobin is regulated according to a set point model we performed a systematic search of PubMed/MEDLINE and Web of Science identifying relevant reports published up to November 2018. Population hemoglobin/erythropoietin level correlations were retrieved, and these empirically derived correlations were compared with the positive correlation implied by a set point model of regulation. Authors of papers containing potentially suitable data were contacted with requests for further analyses, and a meta-analysis was performed. Twelve correlations between hemoglobin and erythropoietin levels from eleven papers were analyzed. None of these correlations were significantly positive, three, restricted to the normal range of hemoglobin, were significantly negative. All but one of the other correlations showed a negative trend. New analyses of previously published data sets resulted in similar findings. In particular a new analysis of large data sets of males (n = 2417) and females (n = 2592) with normal range hemoglobin levels, revealed significantly negative correlations. A meta-analysis of our results indicated that the data overall are not consistent with a positive relationship between hemoglobin and erythropoietin (P < 0.0001). Population data indicate that individuals do not have set point levels of hemoglobin.

    Original languageEnglish
    Article numbere14153
    Pages (from-to)1-10
    Number of pages10
    JournalPhysiological Reports
    Volume7
    Issue number12
    DOIs
    Publication statusPublished - 1 Jul 2019

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    Hemoglobins
    Oxygen
    Population
    Erythropoietin
    Meta-Analysis
    Reference Values
    Hormones
    PubMed
    MEDLINE
    Datasets

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    Fitzgerald, S. P., Grote Beverborg, N., Beguin, Y., Artunc, F., Falhammar, H., & Bean, N. G. (2019). Population data provide evidence against the presence of a set point for hemoglobin levels or tissue oxygen delivery. Physiological Reports, 7(12), 1-10. [e14153]. https://doi.org/10.14814/phy2.14153
    Fitzgerald, Stephen P. ; Grote Beverborg, Niels ; Beguin, Yves ; Artunc, Ferruh ; Falhammar, Henrik ; Bean, Nigel G. / Population data provide evidence against the presence of a set point for hemoglobin levels or tissue oxygen delivery. In: Physiological Reports. 2019 ; Vol. 7, No. 12. pp. 1-10.
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    abstract = "Hemoglobin levels are believed to be regulated as per a set point model of regulation. This model of regulation, by which specific levels of a parameter are targeted and defended by physiological systems, implies a particular population correlation between the parameter and its controlling hormone. Empirical population correlations of other parameters and their controlling hormones, have denied the presence of such set point-based regulation. To assess if hemoglobin is regulated according to a set point model we performed a systematic search of PubMed/MEDLINE and Web of Science identifying relevant reports published up to November 2018. Population hemoglobin/erythropoietin level correlations were retrieved, and these empirically derived correlations were compared with the positive correlation implied by a set point model of regulation. Authors of papers containing potentially suitable data were contacted with requests for further analyses, and a meta-analysis was performed. Twelve correlations between hemoglobin and erythropoietin levels from eleven papers were analyzed. None of these correlations were significantly positive, three, restricted to the normal range of hemoglobin, were significantly negative. All but one of the other correlations showed a negative trend. New analyses of previously published data sets resulted in similar findings. In particular a new analysis of large data sets of males (n = 2417) and females (n = 2592) with normal range hemoglobin levels, revealed significantly negative correlations. A meta-analysis of our results indicated that the data overall are not consistent with a positive relationship between hemoglobin and erythropoietin (P < 0.0001). Population data indicate that individuals do not have set point levels of hemoglobin.",
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    Fitzgerald, SP, Grote Beverborg, N, Beguin, Y, Artunc, F, Falhammar, H & Bean, NG 2019, 'Population data provide evidence against the presence of a set point for hemoglobin levels or tissue oxygen delivery', Physiological Reports, vol. 7, no. 12, e14153, pp. 1-10. https://doi.org/10.14814/phy2.14153

    Population data provide evidence against the presence of a set point for hemoglobin levels or tissue oxygen delivery. / Fitzgerald, Stephen P.; Grote Beverborg, Niels; Beguin, Yves; Artunc, Ferruh; Falhammar, Henrik; Bean, Nigel G.

    In: Physiological Reports, Vol. 7, No. 12, e14153, 01.07.2019, p. 1-10.

    Research output: Contribution to journalArticleResearchpeer-review

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