TY - CHAP
T1 - Positron Emission Tomography and Magnetic Resonance Imaging in Experimental Human Malaria to Identify Organ-Specific Changes in Morphology and Glucose Metabolism
T2 - A Prospective Cohort Study
AU - Woodford, John
AU - Gillman, Ashley
AU - Jenvey, Peter
AU - Roberts, Jennie
AU - Woolley, Stephen
AU - Barber, Bridget E.
AU - Fernandez, Melissa
AU - Rose, Stephen
AU - Tomas, Paul
AU - Anstey, Nicholas M.
AU - McCarthy, James S.
N1 - Publisher Copyright:
© 2023 Jenny Stanford Publishing Pte. Ltd.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - The tissue distribution of P. falciparum on autopsy has been well described. In a seminal publication by Marchiafava and Bignami, the greatest concentration of schizonts was found in the brain, followed by the lungs, spleen, bone marrow, liver, and intestines. Magnetic resonance imaging and functional imaging using nuclear medicine such as positron emission tomography may be useful noninvasive methods to study deep tissue processes and organ-specific tropism, particularly in early and non-severe infection. Changes in splenic imaging metrics may be associated with either increased parasite or host activity, or a combination of both. To date, the ability to localize the pathology of malaria in life has been limited, and direct evaluation of sequestration and organ-specific parasite tropism has relied upon animal models and postmortem studies.
AB - The tissue distribution of P. falciparum on autopsy has been well described. In a seminal publication by Marchiafava and Bignami, the greatest concentration of schizonts was found in the brain, followed by the lungs, spleen, bone marrow, liver, and intestines. Magnetic resonance imaging and functional imaging using nuclear medicine such as positron emission tomography may be useful noninvasive methods to study deep tissue processes and organ-specific tropism, particularly in early and non-severe infection. Changes in splenic imaging metrics may be associated with either increased parasite or host activity, or a combination of both. To date, the ability to localize the pathology of malaria in life has been limited, and direct evaluation of sequestration and organ-specific parasite tropism has relied upon animal models and postmortem studies.
KW - biomimetic 18-F fluorodeoxyglucose (FDG)
KW - body mass index (BMI)
KW - confidence interval (CI)
KW - functional imaging
KW - hepatic imaging
KW - induced blood-stage malaria (IBSM)
KW - infected red blood cells (iRBCs)
KW - magnetic resonance imaging (MRI)
KW - malaria
KW - nuclear medicine
KW - Plasmodium falciparum (Pf)
KW - Plasmodium vivax (Pv)
KW - positron emission tomography (PET)
KW - quantitative polymerase chain reaction (qPCR)
KW - regions of interest (ROIs)
KW - splenic imaging
KW - splenic tropism
KW - standardized uptake values (SUVs)
KW - Strengthening The Reporting of Observational Studies in Epidemiology (STROBE)
KW - upper limit of normal (ULN)
KW - vertebral bone marrow imaging
UR - http://www.scopus.com/inward/record.url?scp=85177532415&partnerID=8YFLogxK
U2 - 10.1201/9781003298038-36
DO - 10.1201/9781003298038-36
M3 - Chapter
AN - SCOPUS:85177532415
SN - 9789814877466
SP - 1001
EP - 1016
BT - Advances in Medical Imaging, Detection, and Diagnosis
A2 - Bawa, Raj
A2 - Audette, Gerald F.
A2 - Bawa, S. R.
A2 - Patel, Bela
A2 - Johnson, Bruce D.
A2 - Khanna, Rajeev
PB - Jenny Stanford Publishing
CY - New York
ER -