The tissue distribution of P. falciparum on autopsy has been well described. In a seminal publication by Marchiafava and Bignami, the greatest concentration of schizonts was found in the brain, followed by the lungs, spleen, bone marrow, liver, and intestines. Magnetic resonance imaging and functional imaging using nuclear medicine such as positron emission tomography may be useful noninvasive methods to study deep tissue processes and organ-specific tropism, particularly in early and non-severe infection. Changes in splenic imaging metrics may be associated with either increased parasite or host activity, or a combination of both. To date, the ability to localize the pathology of malaria in life has been limited, and direct evaluation of sequestration and organ-specific parasite tropism has relied upon animal models and postmortem studies.
|Title of host publication
|Advances in Medical Imaging, Detection, and Diagnosis
|Raj Bawa, Gerald F. Audette, S. R. Bawa, Bela Patel, Bruce D. Johnson, Rajeev Khanna
|Place of Publication
|Jenny Stanford Publishing
|Number of pages
|Published - 1 Jan 2023