Predicting the Clinical Outcome of Severe Falciparum Malaria in African Children: Findings From a Large Randomized Trial

Lorenz Von Seidlein, Rasaq Olaosebikan, Ilse Hendriksen, Sue J Lee, Olanrewaju T Adedoyin, Tsiri Agbenyega, Samuel Blay Nguah, Kalifa Bojang, Jacqueline Deen, Jennifer Evans, Caterina Fanello, Ermelinda Gomes, Alinia Pedro, Catherine Kahabuka, Corine Karema, Esther Kivaya, Kathryn Maitland, Olugbenga A Mokuolu, George Mtove, Juliet Mwanga-AmumpaireBehzad Nadjm, Margaret Nansumba, Wirichada Pan Ngum, Marie A Onyamboko, Hugh Reyburn, Tharisara Sakulthaew, Kamolrat Silamut, Antoinette K Tshefu, Noella Umulisa, Samwel Gesase, Nicholas Day, Nicholas J White, Arjen Dondorp

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    Abstract

    Background: Data from the largest randomized, controlled trial for the treatment of children hospitalized with severe malaria were used to identify such predictors of a poor outcome from severe malaria.

    Methods: African children (<15 years) with severe malaria participated in a randomized comparison of parenteral artesunate and parenteral quinine in 9 African countries. Detailed clinical assessment was performed on admission. Parasite densities were assessed in a reference laboratory. Predictors of death were examined using a multivariate logistic regression model.

    Results: Twenty indicators of disease severity were assessed, out of which 5 (base deficit, impaired consciousness, convulsions, elevated blood urea, and underlying chronic illness) were associated independently with death. Tachypnea, respiratory distress, deep breathing, shock, prostration, low pH, hyperparasitemia, severe anemia, and jaundice were statistically significant indicators of death in the univariate analysis but not in the multivariate model. Age, glucose levels, axillary temperature, parasite density, heart rate, blood pressure, and blackwater fever were not related to death in univariate models.

    Conclusions: Acidosis, cerebral involvement, renal impairment, and chronic illness are key independent predictors for a poor outcome in African children with severe malaria. Mortality is markedly increased in cerebral malaria combined with acidosis.
    Original languageEnglish
    Pages (from-to)1080-1090
    Number of pages11
    JournalClinical Infectious Diseases
    Volume54
    Issue number8
    DOIs
    Publication statusPublished - 15 May 2012

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    Von Seidlein, L., Olaosebikan, R., Hendriksen, I., Lee, S. J., Adedoyin, O. T., Agbenyega, T., Nguah, S. B., Bojang, K., Deen, J., Evans, J., Fanello, C., Gomes, E., Pedro, A., Kahabuka, C., Karema, C., Kivaya, E., Maitland, K., Mokuolu, O. A., Mtove, G., ... Dondorp, A. (2012). Predicting the Clinical Outcome of Severe Falciparum Malaria in African Children: Findings From a Large Randomized Trial. Clinical Infectious Diseases, 54(8), 1080-1090. https://doi.org/10.1093/cid/cis034