Pregnancy And Neonatal Diabetes Outcomes in Remote Australia (PANDORA) Study

Louise Maple-Brown; Alex Brown; I-Lynn Lee; Christine Connors; Jeremy Oats; Harold McIntyre; Cherie Whitbread; Elizabeth Moore; Danielle Longmore; Glynis Dent; Sumaria Corpus; Marie Kirkwood; S Svenson; Paula van Dokkum; Sridhar Chitturi; Sujatha Thomas; Sandra Eades; Monique Stone; Mark Harris; Chrissie Inglis; Karen Dempsey; Michelle Dowden; Michael Lynch; Jacqueline Anne Boyle; Susan Sayers; Jonathan Shaw; Paul Zimmet; Kerin O'Dea

doi:10.1186/1471-2393-13-221

Pregnancy And Neonatal Diabetes Outcomes in Remote Australia (PANDORA) Study

Louise Maple-Brown, Alex Brown, I-Lynn Lee, Christine Connors, Jeremy Oats, Harold McIntyre, Cherie Whitbread, Elizabeth Moore, Danielle Longmore, Glynis Dent, Sumaria Corpus, Marie Kirkwood, S Svenson, Paula van Dokkum, Sridhar Chitturi, Sujatha Thomas, Sandra Eades, Monique Stone, Mark Harris, Chrissie InglisKaren Dempsey, Michelle Dowden, Michael Lynch, Jacqueline Anne Boyle, Susan Sayers, Jonathan Shaw, Paul Zimmet, Kerin O'Dea

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Abstract

Background: Diabetes in pregnancy carries an increased risk of adverse pregnancy outcomes for both the mother and foetus, but it also provides an excellent early opportunity for intervention in the life course for both mother and baby. In the context of the escalating epidemic of chronic diseases among Indigenous Australians, it is vital that this risk is reduced as early as possible in the life course of the individual. The aims of the PANDORA Study are to: (i) accurately assess rates of diabetes in pregnancy in the Northern Territory (NT) of Australia, where 38% of babies are born to Indigenous mothers; (ii) assess demographic, clinical, biochemical, anthropometric, socioeconomic and early life development factors that may contribute to key maternal and neonatal birth outcomes associated with diabetes in pregnancy; and (iii) monitor relevant post-partum clinical outcomes for both the mothers and their babies.

Methods/Design: Eligible participants are all NT women with diabetes in pregnancy aged 16 years and over. Information collected includes: standard antenatal clinical information, diagnosis and management of diabetes in pregnancy, socio-economic status, standard clinical birth information (delivery, gestational age, birth weight, adverse antenatal and birth outcomes). Cord blood is collected at the time of delivery and detailed neonatal anthropometric measurements performed within 72 hours of birth. Information will also be collected regarding maternal post-partum glucose tolerance and cardio-metabolic risk factor status, breastfeeding and growth of the baby up to 2 years post-partum in the first instance.

Discussion: This study will accurately document rates and outcomes of diabetes in pregnancy in the NT of Australia, including the high-risk Indigenous Australian population. The results of this study should contribute to policy and clinical guidelines with the goal of reducing the future risk of obesity and diabetes in both mothers and their offspring.

Original language	English
Article number	221
Pages (from-to)	1-8
Number of pages	8
Journal	BMC Pregnancy and Childbirth
Volume	13
DOIs	https://doi.org/10.1186/1471-2393-13-221
Publication status	Published - 2013

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Maple-Brown, L., Brown, A., Lee, I.-L., Connors, C., Oats, J., McIntyre, H., Whitbread, C., Moore, E., Longmore, D., Dent, G., Corpus, S., Kirkwood, M., Svenson, S., van Dokkum, P., Chitturi, S., Thomas, S., Eades, S., Stone, M., Harris, M., ... O'Dea, K. (2013). Pregnancy And Neonatal Diabetes Outcomes in Remote Australia (PANDORA) Study. BMC Pregnancy and Childbirth, 13, 1-8. Article 221. https://doi.org/10.1186/1471-2393-13-221

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title = "Pregnancy And Neonatal Diabetes Outcomes in Remote Australia (PANDORA) Study",

abstract = "Background: Diabetes in pregnancy carries an increased risk of adverse pregnancy outcomes for both the mother and foetus, but it also provides an excellent early opportunity for intervention in the life course for both mother and baby. In the context of the escalating epidemic of chronic diseases among Indigenous Australians, it is vital that this risk is reduced as early as possible in the life course of the individual. The aims of the PANDORA Study are to: (i) accurately assess rates of diabetes in pregnancy in the Northern Territory (NT) of Australia, where 38% of babies are born to Indigenous mothers; (ii) assess demographic, clinical, biochemical, anthropometric, socioeconomic and early life development factors that may contribute to key maternal and neonatal birth outcomes associated with diabetes in pregnancy; and (iii) monitor relevant post-partum clinical outcomes for both the mothers and their babies. Methods/Design: Eligible participants are all NT women with diabetes in pregnancy aged 16 years and over. Information collected includes: standard antenatal clinical information, diagnosis and management of diabetes in pregnancy, socio-economic status, standard clinical birth information (delivery, gestational age, birth weight, adverse antenatal and birth outcomes). Cord blood is collected at the time of delivery and detailed neonatal anthropometric measurements performed within 72 hours of birth. Information will also be collected regarding maternal post-partum glucose tolerance and cardio-metabolic risk factor status, breastfeeding and growth of the baby up to 2 years post-partum in the first instance. Discussion: This study will accurately document rates and outcomes of diabetes in pregnancy in the NT of Australia, including the high-risk Indigenous Australian population. The results of this study should contribute to policy and clinical guidelines with the goal of reducing the future risk of obesity and diabetes in both mothers and their offspring. ",

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author = "Louise Maple-Brown and Alex Brown and I-Lynn Lee and Christine Connors and Jeremy Oats and Harold McIntyre and Cherie Whitbread and Elizabeth Moore and Danielle Longmore and Glynis Dent and Sumaria Corpus and Marie Kirkwood and S Svenson and {van Dokkum}, Paula and Sridhar Chitturi and Sujatha Thomas and Sandra Eades and Monique Stone and Mark Harris and Chrissie Inglis and Karen Dempsey and Michelle Dowden and Michael Lynch and Boyle, {Jacqueline Anne} and Susan Sayers and Jonathan Shaw and Paul Zimmet and Kerin O'Dea",

year = "2013",

doi = "10.1186/1471-2393-13-221",

language = "English",

volume = "13",

pages = "1--8",

journal = "BMC Pregnancy and Childbirth",

issn = "1471-2393",

publisher = "BioMed Central",

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Maple-Brown, L, Brown, A, Lee, I-L, Connors, C, Oats, J, McIntyre, H, Whitbread, C, Moore, E, Longmore, D, Dent, G, Corpus, S, Kirkwood, M, Svenson, S, van Dokkum, P, Chitturi, S, Thomas, S, Eades, S, Stone, M, Harris, M, Inglis, C, Dempsey, K, Dowden, M, Lynch, M, Boyle, JA, Sayers, S, Shaw, J, Zimmet, P & O'Dea, K 2013, 'Pregnancy And Neonatal Diabetes Outcomes in Remote Australia (PANDORA) Study', BMC Pregnancy and Childbirth, vol. 13, 221, pp. 1-8. https://doi.org/10.1186/1471-2393-13-221

TY - JOUR

T1 - Pregnancy And Neonatal Diabetes Outcomes in Remote Australia (PANDORA) Study

AU - Maple-Brown, Louise

AU - Brown, Alex

AU - Lee, I-Lynn

AU - Connors, Christine

AU - Oats, Jeremy

AU - McIntyre, Harold

AU - Whitbread, Cherie

AU - Moore, Elizabeth

AU - Longmore, Danielle

AU - Dent, Glynis

AU - Corpus, Sumaria

AU - Kirkwood, Marie

AU - Svenson, S

AU - van Dokkum, Paula

AU - Chitturi, Sridhar

AU - Thomas, Sujatha

AU - Eades, Sandra

AU - Stone, Monique

AU - Harris, Mark

AU - Inglis, Chrissie

AU - Dempsey, Karen

AU - Dowden, Michelle

AU - Lynch, Michael

AU - Boyle, Jacqueline Anne

AU - Sayers, Susan

AU - Shaw, Jonathan

AU - Zimmet, Paul

AU - O'Dea, Kerin

PY - 2013

Y1 - 2013

N2 - Background: Diabetes in pregnancy carries an increased risk of adverse pregnancy outcomes for both the mother and foetus, but it also provides an excellent early opportunity for intervention in the life course for both mother and baby. In the context of the escalating epidemic of chronic diseases among Indigenous Australians, it is vital that this risk is reduced as early as possible in the life course of the individual. The aims of the PANDORA Study are to: (i) accurately assess rates of diabetes in pregnancy in the Northern Territory (NT) of Australia, where 38% of babies are born to Indigenous mothers; (ii) assess demographic, clinical, biochemical, anthropometric, socioeconomic and early life development factors that may contribute to key maternal and neonatal birth outcomes associated with diabetes in pregnancy; and (iii) monitor relevant post-partum clinical outcomes for both the mothers and their babies. Methods/Design: Eligible participants are all NT women with diabetes in pregnancy aged 16 years and over. Information collected includes: standard antenatal clinical information, diagnosis and management of diabetes in pregnancy, socio-economic status, standard clinical birth information (delivery, gestational age, birth weight, adverse antenatal and birth outcomes). Cord blood is collected at the time of delivery and detailed neonatal anthropometric measurements performed within 72 hours of birth. Information will also be collected regarding maternal post-partum glucose tolerance and cardio-metabolic risk factor status, breastfeeding and growth of the baby up to 2 years post-partum in the first instance. Discussion: This study will accurately document rates and outcomes of diabetes in pregnancy in the NT of Australia, including the high-risk Indigenous Australian population. The results of this study should contribute to policy and clinical guidelines with the goal of reducing the future risk of obesity and diabetes in both mothers and their offspring.

AB - Background: Diabetes in pregnancy carries an increased risk of adverse pregnancy outcomes for both the mother and foetus, but it also provides an excellent early opportunity for intervention in the life course for both mother and baby. In the context of the escalating epidemic of chronic diseases among Indigenous Australians, it is vital that this risk is reduced as early as possible in the life course of the individual. The aims of the PANDORA Study are to: (i) accurately assess rates of diabetes in pregnancy in the Northern Territory (NT) of Australia, where 38% of babies are born to Indigenous mothers; (ii) assess demographic, clinical, biochemical, anthropometric, socioeconomic and early life development factors that may contribute to key maternal and neonatal birth outcomes associated with diabetes in pregnancy; and (iii) monitor relevant post-partum clinical outcomes for both the mothers and their babies. Methods/Design: Eligible participants are all NT women with diabetes in pregnancy aged 16 years and over. Information collected includes: standard antenatal clinical information, diagnosis and management of diabetes in pregnancy, socio-economic status, standard clinical birth information (delivery, gestational age, birth weight, adverse antenatal and birth outcomes). Cord blood is collected at the time of delivery and detailed neonatal anthropometric measurements performed within 72 hours of birth. Information will also be collected regarding maternal post-partum glucose tolerance and cardio-metabolic risk factor status, breastfeeding and growth of the baby up to 2 years post-partum in the first instance. Discussion: This study will accurately document rates and outcomes of diabetes in pregnancy in the NT of Australia, including the high-risk Indigenous Australian population. The results of this study should contribute to policy and clinical guidelines with the goal of reducing the future risk of obesity and diabetes in both mothers and their offspring.

KW - glucose

KW - hemoglobin A1c

KW - article

KW - Australia

KW - birth weight

KW - breast feeding

KW - cardiometabolic risk

KW - gestational age

KW - glucose tolerance

KW - human

KW - newborn diabetes mellitus

KW - outcome assessment

KW - pregnancy

KW - pregnancy diabetes mellitus

KW - pregnancy outcome

KW - pregnant woman

KW - puerperium

KW - umbilical cord blood

KW - Anthropometry

KW - Birth Weight

KW - Breast Feeding

KW - Child Development

KW - Diabetes, Gestational

KW - Female

KW - Gestational Age

KW - Glucose Tolerance Test

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Northern Territory

KW - Obstetric Labor Complications

KW - Pregnancy

KW - Pregnancy in Diabetics

KW - Pregnancy Outcome

KW - Research Design

KW - Social Class

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U2 - 10.1186/1471-2393-13-221

DO - 10.1186/1471-2393-13-221

M3 - Comment/debate

C2 - PubMed:24289168

SN - 1471-2393

VL - 13

SP - 1

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JO - BMC Pregnancy and Childbirth

JF - BMC Pregnancy and Childbirth

M1 - 221

ER -

Pregnancy And Neonatal Diabetes Outcomes in Remote Australia (PANDORA) Study

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