Prevalence and Sequence Diversity of a Factor Required for Actin-Based Motility in Natural Populations of Burkholderia Species

C Sitthidet, Joanne M Stevens, Narisara Chantratitia, Bart Currie, Sharon J Peacock, S Korbsrisate, Mark Stevens

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    Abstract

    Actin-based motility of the melioidosis pathogen Burkholderia pseudomallei requires BimA. We report a high degree of conservation of bimA in 99 B. pseudomallei isolates from the area of endemicity. A geographically restricted subset of B. pseudomallei isolates harbored a B. mallei-like bimA allele (12.1%), confounding a differential diagnostic test based on amplification of species-specific bimA regions. Copyright � 2008, American Society for Microbiology. All Rights Reserved.
    Original languageEnglish
    Pages (from-to)2418-2422
    Number of pages5
    JournalJournal of Clinical Microbiology
    Volume46
    Issue number7
    Publication statusPublished - 2008

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    Sitthidet, C., Stevens, J. M., Chantratitia, N., Currie, B., Peacock, S. J., Korbsrisate, S., & Stevens, M. (2008). Prevalence and Sequence Diversity of a Factor Required for Actin-Based Motility in Natural Populations of Burkholderia Species. Journal of Clinical Microbiology, 46(7), 2418-2422.